AP-1/c-Fos supports SIV and HIV-1 latency in CD4 T cells infected in vivo

Autor: Viviana Cobos Jiménez, Aviva Geretz, Andrey Tokarev, Philip K. Ehrenberg, Selase Deletsu, Kawthar Machmach, Prakriti Mudvari, J. Natalie Howard, Amanda Zelkoski, Dominic Paquin-Proulx, Gregory Q. Del Prete, Caroline Subra, Eli A. Boritz, Alberto Bosque, Rasmi Thomas, Diane L. Bolton

Publikováno v: iScience, Vol 26, Iss 10, Pp 108015- (2023)

Summary: Persistent HIV-1 reservoirs of infected CD4 T cells are a major barrier to HIV-1 cure, although the mechanisms by which they are established and maintained in vivo remain poorly characterized. To elucidate host cell gene expression patterns

Externí odkaz: https://doaj.org/article/610f567e63764468b36e1cbb767d05df

Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8+ T cells

Autor: Hiroshi Takata, Juyeon C. Kakazu, Julie L. Mitchell, Eugene Kroon, Donn J. Colby, Carlo Sacdalan, Hongjun Bai, Philip K. Ehrenberg, Aviva Geretz, Supranee Buranapraditkun, Suteeraporn Pinyakorn, Jintana Intasan, Somporn Tipsuk, Duanghathai Suttichom, Peeriya Prueksakaew, Thep Chalermchai, Nitiya Chomchey, Nittaya Phanuphak, Mark de Souza, Nelson L. Michael, Merlin L. Robb, Elias K. Haddad, Trevor A Crowell, Sandhya Vasan, Victor G. Valcour, Daniel C. Douek, Rasmi Thomas, Morgane Rolland, Nicolas Chomont, Jintanat Ananworanich, Lydie Trautmann, Nipat Teeratakulpisarn, Supanit Pattanachaiwit, Somchai Sriplienchan, Ponpen Tantivitayakul, Ratchapong Kanaprach, Kiat Ruxrungtham, Netsiri Dumrongpisutikul, Ponlapat Rojnuckarin, Suthat Chottanapund, Kultida Poltavee, Tassanee Luekasemsuk, Hathairat Savadsuk, Suwanna Puttamsawin, Khunthalee Benjapornpong, Nisakorn Ratnaratorn, Kamonkan Tangnaree, Chutharat Munkong, Rommanus Thaimanee, Patcharin Eamyoung, Sasiwimol Ubolyam, Sukalya Lerdlum, Sopark Manasnayakorn, Rugsun Rerknimitr, Sunee Sirivichayakul, Phandee Wattanaboonyongcharoen, Jessica Cowden, Alexandra Schuetz, Siriwat Akapirat, Nampueng Churikanont, Saowanit Getchalarat, Denise Hsu, Ellen Turk, Oratai Butterworth, Mark Milazzo, Leigh Anne Eller, Julie Ake, Serena Spudich, CAPT Lawrence Fox, Silvia Ratto-Kim, Victor DeGruttola, Yotin Chinvarun, Pasiri Sithinamsuwan, James Fletcher, Bruce Shiramizu

Publikováno v: EBioMedicine, Vol 84, Iss , Pp 104253- (2022)

Summary: Background: Harnessing CD8+ T cell responses is being explored to achieve HIV remission. Although HIV-specific CD8+ T cells become dysfunctional without treatment, antiretroviral therapy (ART) partially restores their function. However, the

Externí odkaz: https://doaj.org/article/9613185aa1dd427ea563c0aff33f6788

HLA-B*57 and B*58 Associate with Predictors of Reservoir Size in an Acutely Treated HIV Cohort

Autor: Shida Shangguan, Philip K. Ehrenberg, Aviva Geretz, Lauryn Butler, Suteeraporn Pinyakorn, Somchai Sriplienchan, Carlo Sacdalan, Nitiya Chomchey, Nittaya Phanuphak, Sodsai Tovanabutra, Sandhya Vasan, Denise Hsu, Rasmi Thomas

Publikováno v: AIDS Research and Human Retroviruses. 39:114-118

Much has been learnt about the role of HLA alleles during natural infection of HIV-1, but far less is known about their role in people living with HIV (PLWH) on suppressive antiretroviral therapy (ART). In this study we used variable selection to ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7385e6c64d383593446e626225dddf
https://doi.org/10.1089/aid.2022.0082

Author response: Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1

Autor: Kelly May, Suwat Chariyalertsak, Shida Shangguan, Peter B. Gilbert, Georgia D. Tomaras, Supachai Rerks-Ngarm, Krystelle Nganou-Makamdop, Eric Lewitus, Slim Fourati, Sheetal Sawant, Nelson L. Michael, LaTonya D. Williams, Aviva Geretz, Rasmi Thomas, Lauren Yum, Philip K. Ehrenberg, Sorachai Nitayaphan, Punnee Pitisuttithum, Gautam Kundu, Daniel C. Douek, Morgane Rolland, Sandhya Vasan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e40099a7e700b276a25afe453efec82
https://doi.org/10.7554/elife.69577.sa2

HLA-B∗46 associates with rapid HIV disease progression in Asian cohorts and prominent differences in NK cell phenotype

Autor: Shuying S. Li, Andrew Hickey, Shida Shangguan, Philip K. Ehrenberg, Aviva Geretz, Lauryn Butler, Gautam Kundu, Richard Apps, Matthew Creegan, Robert J. Clifford, Suteeraporn Pinyakorn, Leigh Anne Eller, Pikunchai Luechai, Peter B. Gilbert, Timothy H. Holtz, Anupong Chitwarakorn, Carlo Sacdalan, Eugène Kroon, Nittaya Phanuphak, Mark de Souza, Jintanat Ananworanich, Robert J. O'Connell, Merlin L. Robb, Nelson L. Michael, Sandhya Vasan, Rasmi Thomas

Publikováno v: Cell Host Microbe
Cell host & microbe, 30(8), 1173-1185.E8. Cell Press

Human leukocyte antigen (HLA) alleles have been linked to HIV disease progression and attributed to differences in cytotoxic T lymphocyte (CTL) epitope representation. These findings are largely based on treatment-naive individuals of European and Af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e430b701ce9f4cd6657d95cf804f651d
https://doi.org/10.1016/j.chom.2022.06.005