Zobrazeno 1 - 10
of 46
pro vyhledávání: '"K E Wells"'
Autor:
Jaap J. Plomp, Dominic J. Wells, Christa L Tanganyika-de Winter, David Bull, Annemieke Aartsma-Rus, John C. W. Hildyard, Sofia Nnorom, K E Wells, Ingrid E.C. Verhaart, Ornella Cappellari
Publikováno v:
Journal of Neuromuscular Diseases
Journal of Neuromuscular Diseases, 8(5), 845-863. IOS PRESS
Journal of Neuromuscular Diseases, 8(5), 845-863. IOS PRESS
Duchenne muscular dystrophy is an X-linked, recessive muscular dystrophy in which the absence of the dystrophin protein leads to fibrosis, inflammation and oxidative stress, resulting in loss of muscle tissue. Drug repurposing, i.e. using drugs alrea
Autor:
Dominic J. Wells, Heather B. Steele-Stallard, K E Wells, Francesco Tedesco, Shilpita Sarcar, W. Wang, S.M. Maffioletti, Thomas Eschenhagen, Ingra Mannhardt, Ornella Cappellari, Peter S. Zammit, Luca Pinton, Louise A. Moyle, M. Ragazzi, A Henderson
Publikováno v:
Neuromuscular Disorders. 28:S13
Autor:
Graham McClorey, Dominic J. Wells, Corinne A. Betts, S Muses, Matthew J.A. Wood, Caroline Godfrey, Kieran Clarke, Carolyn A. Carr, Suzan M. Hammond, Amer F. Saleh, Caroline Woffindale, Michael J. Gait, K E Wells
Publikováno v:
Scientific Reports
Duchenne muscular dystrophy (DMD) is caused by absence of the integral structural protein, dystrophin, which renders muscle fibres susceptible to injury and degeneration. This ultimately results in cardiorespiratory dysfunction, which is the predomin
Publikováno v:
Gene Therapy. 11:884-893
One of the possible therapies for Duchenne muscular dystrophy (DMD) is the introduction of a functional copy of the dystrophin gene into the patient. For this approach to be effective, therapeutic levels and long-term expression of the protein need t
Publikováno v:
FEBS Letters. 552:145-149
The use of antisense oligonucleotides (AOs) to induce exon skipping leading to generation of an in-frame dystrophin protein product could be of benefit in around 70% of Duchenne muscular dystrophy patients. We describe the use of hyaluronidase enhanc
Publikováno v:
Gene Therapy. 10:504-512
The efficiency of plasmid gene transfer in skeletal muscle is significantly enhanced by pretreatment with hyaluronidase and the application of an electrical field to the muscle following the injection of plasmid DNA, a process referred to as electrot
Autor:
Dominic J. Wells, H. Booler, R L Terry, Callum Parr, M.R. Ackroyd, M. Fernandez-Fuente, J. Kim, Manoli Kavishwar, E. Lacey, K E Wells, C. Whitmore, Attia Ashraf, Francesco Muntoni, Susan C. Brown
Publikováno v:
Human molecular genetics. 23(7)
Mutations in fukutin-related protein (FKRP) underlie a group of muscular dystrophies associated with the hypoglycosylation of α-dystroglycan (α-DG), a proportion of which show central nervous system involvement. Our original FKRP knock-down mouse (
Autor:
Martin C. Robson, Paul D. Smith, K E Wells, Francis Ko, S Singh, R Falcone, A Kuhn, S P Maggi, W G Lyle
Publikováno v:
Annals of Plastic Surgery. 44:387-391
Periprosthetic breast capsules composed of fibrotic collagenous material with increased collagen production are not dissimilar to other fibrotic conditions occurring in other organs. Fibrosis in the lung, liver, kidney, and skin has been associated w
Autor:
S Muses, E O'Donovan, Matthew J.A. Wood, Caroline Godfrey, R L Terry, M J Gait, John C. W. Hildyard, Graham McClorey, K E Wells, S El Andaloussi, Ornella Cappellari, Suzan M. Hammond, Dominic J. Wells, Corinne A. Betts, Thibault Coursindel
Publikováno v:
Neuromuscular Disorders. 25:S312-S313
We examined the effects on muscle physiology of restoring different levels of dystrophin in mdx mice with established dystrophic pathophysiology (12 weeks and older). Dystrophin expression was induced very efficiently using cell penetrating peptides
Autor:
A Poole, Jill McMahon, Jake Maule, Keith Foster, R Kingston, Dominic J. Wells, E Damien, K E Wells
Publikováno v:
FEBS Letters. 407:164-168
Long-term high-level in vivo gene expression appears to depend on the promoter chosen to drive the gene of choice. In many cases the promoter appears to `switch off' some time after in vivo gene transfer. We demonstrate that, following intramuscular