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Issues on fit-for-purpose validation of a panel of ELISAs for application as biomarkers in clinical trials of anti-Angiogenic drugs

Autor: Gordon C Jayson, Caroline Dive, Alastair Greystoke, K E Brookes, Alison Backen, Jeffrey Cummings, Timothy H Ward

Publikováno v: British Journal of Cancer

Background: Successful introduction of new anticancer agents into the clinic is often hampered by a lack of qualified biomarkers. Studies have been conducted of 17 ELISAs representing a potential panel of pharmacodynamic/predictive biomarkers for dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b690213d9fae17a62bac9fd4b87f54d5
http://europepmc.org/articles/PMC2869162

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Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours

Autor: Alison Hogg, T Klymenko, Guy Makin, K E Brookes, Jennifer Adamski, Timothy H Ward, Sarah Holt, Edward J. Estlin, Deema Hussein, Caroline Dive

Publikováno v: British Journal of Cancer

Background: Despite substantial improvements in childhood cancer survival, drug resistance remains problematic for several paediatric tumour types. The urgent need to access novel agents to treat drug-resistant disease should be expedited by pre-clin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3642b1e6f5b00d4ea586455b2ebfdf41
https://doi.org/10.1038/sj.bjc.6605100

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Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding

Autor: S H Leech, Bernard M. Corfe, A L Prais, J S Waby, Hari C. Chirakkal, K E Brookes

Publikováno v: Oncogene. 25:7192-7200

Butyrate is a key bioactive product of dietary fibre fermentation thought to play a key role in cancer prevention. One contributory mechanism in this role is the regulation of apoptosis by butyrate. As butyrate shows low levels of toxicity, the mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5b83c1ec62382dffb9a2132355aa9a
https://doi.org/10.1038/sj.onc.1209702

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Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents

Autor: Sarah Holt, Guy Makin, Caroline Dive, K E Brookes

Publikováno v: Oncology Reports. 25

Resistance to conventional chemotherapy is a major problem in several paediatric tumours. One explanation for this is that tumour cells are unable to engage apoptosis after cytotoxic drug-induced damage. Inhibitor of apoptosis proteins (IAPs) functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025bd02d8d0eb9445dab2e49312cc5ea
https://doi.org/10.3892/or.2011.1167

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