Výsledky vyhledávání - "K E, Thummel"

Akademický článek

A Systematic Review Exploring Empirical Pharmacogenomics Research Within Global Indigenous Populations.

Autor: Nasir, Bushra Farah¹ (AUTHOR) b.nasir@uq.edu.au, Vinayagam, Ritwika² (AUTHOR), Massi, Luciana³ (AUTHOR), Nagaraj, Shivashankar H.^4,5 (AUTHOR), Toombs, Maree⁶ (AUTHOR), Rae, Kym M.³ (AUTHOR)

Publikováno v: Molecular Genetics & Genomic Medicine. Oct2024, Vol. 12 Issue 10, p1-25. 25p.

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Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats

Autor: D K, Spracklin, M E, Emery, K E, Thummel, E D, Kharasch

Publikováno v: Acta anaesthesiologica Scandinavica. 47(6)

Cytochrome P4502E1(CYP2E1)-mediated oxidation of halothane to a reactive intermediate (trifluoroacyl chloride) that covalently binds to hepatic proteins forming trifluoroacetylated neoantigens is believed to be the initiating event in a complex immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c99d6bf0e235051425dcdc35c838358
https://pubmed.ncbi.nlm.nih.gov/12803597

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Review

Metabolic Drug Interactions. Edited by R. H. Levy, K. E. Thummel, W. F. Trayer, P. D. Hansten and M. Eichelbaum. Lippincott, Williams and Wilkins, 2000.

Autor: Leonard, B. E.

Publikováno v: Human Psychopharmacology: Clinical & Experimental. Jul2000, Vol. 15 Issue 5, p390-390. 1p.

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Induction of CYP3A4 by 1 alpha,25-dihydroxyvitamin D3 is human cell line-specific and is unlikely to involve pregnane X receptor

Autor: P, Schmiedlin-Ren, K E, Thummel, J M, Fisher, M F, Paine, P B, Watkins

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(11)

Under certain culture conditions, exposure of the human colon adenocarcinoma cell line Caco-2 to 1,25-(OH)(2)-D(3) induces expression of CYP3A4 to levels comparable to that in human small intestinal epithelium. To determine whether 1,25-(OH)(2)-D(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b085b5c42aa1e613a34261af74f05d6d
https://pubmed.ncbi.nlm.nih.gov/11602520

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Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen

Autor: H, Dong, R L, Haining, K E, Thummel, A E, Rettie, S D, Nelson

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 28(12)

Acetaminophen (APAP), a widely used analgesic and antipyretic agent, can cause acute hepatic necrosis in both humans and experimental animals when consumed in large doses. It is generally accepted that N-acetyl-p-benzoquinone imine (NAPQI) is the tox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb0a12cc708083f47bf44397eb27c3ce
https://pubmed.ncbi.nlm.nih.gov/11095574

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Immunoquantitation of FMO1 in human liver, kidney, and intestine

Autor: C K, Yeung, D H, Lang, K E, Thummel, A E, Rettie

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 28(9)

To determine the level of FMO1 protein present in human liver tissues, a monospecific antibody was prepared and a sensitive Western blotting procedure with enhanced chemiluminescence detection was developed. Human FMO1, purified from insect cells exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b66b101682fa20f85b71f08adbb7aacf
https://pubmed.ncbi.nlm.nih.gov/10950857

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Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells

Autor: M A, Gibbs, M T, Baillie, D D, Shen, K L, Kunze, K E, Thummel

Publikováno v: Pharmaceutical research. 17(3)

The intestinal metabolism of some CYP3A substrates can be altered profoundly by co-administration of the potent inhibitor, ketoconazole. The present research was conducted to test the hypothesis that, unlike the inhibition kinetics observed with isol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ef793fa40b39e2b4821ed335bfdb770
https://pubmed.ncbi.nlm.nih.gov/10801218

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Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans

Autor: M G, Emery, C, Jubert, K E, Thummel, E D, Kharasch

Publikováno v: The Journal of pharmacology and experimental therapeutics. 291(1)

Disulfiram (DSF) is a mechanism-based inhibitor of cytochrome P-450 2E1 (CYP2E1), resulting in loss of CYP2E1 protein and activity, which may be useful in preventing CYP2E1-mediated xenobiotic toxicity. The duration of inhibition after a single DSF d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::33e9bce14a1672422cd2d4b0b9b92673
https://pubmed.ncbi.nlm.nih.gov/10490907

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Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines

Autor: S, Madani, M F, Paine, L, Lewis, K E, Thummel, D D, Shen

Publikováno v: Pharmaceutical research. 16(8)

To assess the role of intestinal CYP2D6 in oral first-pass drug clearance by comparing the enzyme content and catalytic activity of a prototype CYP2D6 substrate, metoprolol, between microsomes prepared from human intestinal mucosa and from human live

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58647d40b0030dbc7fca8b5bf075e2a9
https://pubmed.ncbi.nlm.nih.gov/10468020

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