Zobrazeno 1 - 8
of 8
pro vyhledávání: '"K E, Rao"'
Publikováno v:
Biochemistry. 31:12076-12082
DNA sequence selectivities in the covalent binding of the antitumor antibiotic saframycins Mx1, Mx3, A, and S have been determined by complementary strand MPE.Fe(II) footprinting and exonuclease III stop assays on two different 545 and 135 base pair
Autor:
R. Houssin, Jean Louis Imbach, Jan Balzarini, K. E. Rao, Christian Bailly, D Mrani, Gilles Gosselin, J.P. Hénichart, J. Zimmermann, Lown Jw, E. De Clercq
Publikováno v:
European Journal of Medicinal Chemistry. 27:331-344
A series of hybrid molecules have been synthesized which result from the combination of a DNA sequence-specific ligand (netropsin) coupled to a DNA-interactive structural component of bleomycins (bithiazole). The DNA binding affinities as well as the
Autor:
K E, Rao, G, Gosselin, D, Mrani, C, Périgaud, J L, Imbach, C, Bailly, J P, Hénichart, P, Colson, C, Houssier, J W, Lown
Publikováno v:
Anti-cancer drug design. 9(3)
The properties of certain hybrids 3 and 5 bearing a photoactivatable psoralen group attached to DNA sequence recognizing lexitropsin carriers have been examined. The hybrids bind to poly(dA-dT) with Kapp of 2.8 and 0.9 x 10(7) M-1, i.e. greater than
Publikováno v:
Chemical research in toxicology. 4(6)
The DNA binding characteristics of new analogues (2-8) of Hoechst 33258 (1), containing pyridine and benzoxazole units and designed for altered base specificity, were evaluated using UV, fluorescence, and circular dichroism studies. Like Hoechst 3325
Publikováno v:
Biochemistry. 29(45)
The novel hybrid duplex alpha-5'-d[TACACA]-3'.beta-5'-r[AUGUGU]-3' was analyzed extensively by 1D and 2D NMR methods. Two forms of the duplex exist in about an 80:20 ratio. Analysis of the exchangeable imino protons of the major component revealed th
Autor:
V. Sasisekharan, K. E. Rao
Publikováno v:
ChemInform. 21
Publikováno v:
Chemical research in toxicology. 3(3)
The sequence-preferential reversible covalent binding of certain saframycin antitumor antibiotics from Streptomyces lavendulae has been examined by complementary-strand methidium propyl-EDTA (MPE) footprinting on an EcoRI/HindIII restriction fragment
Publikováno v:
Anti-cancer drug design. 5(1)
The DNA binding and sequence specificity of a group of six novel thiazole containing lexitropsins related to the natural anti-tumor antibiotic distamycin have been examined by complementary strand MPE footprinting on two restriction fragments of pBR3