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Use of CTX-I and PINP as bone turnover markers: National Bone Health Alliance recommendations to standardize sample handling and patient preparation to reduce pre-analytical variability

Autor: Nicholas Hoyle, Marie-Eva Pickering, Richard Eastell, Pawel Szulc, K. E. Naylor, Elizabeth Leary

Publikováno v: Annales de biologie clinique. 76:373-391

The International osteoporosis foundation and the International federation of clinical chemistry (IFCC) Bone marker standards working group have identified N-terminal propeptide of type I procollagen (PINP) and C-terminal telopeptide of type I collag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9789c92fdf1cb06aef5a98bfaf425f
https://doi.org/10.1684/abc.2018.1363

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Effects of discontinuing oral bisphosphonate treatments for postmenopausal osteoporosis on bone turnover markers and bone density

Autor: K. E. Naylor, Jennifer Walsh, Mike Bradburn, Eugene V. McCloskey, Fatma Gossiel, R. Eastell, Nicola Peel, Margaret Paggiosi

Publikováno v: Osteoporosis International. 29:1407-1417

The antiresorptive potency varies between different bisphosphonates. We investigated the effect of stopping oral bisphosphonate treatment for postmenopausal osteoporosis (ibandronate, alendronate, risedronate) on BTMs and BMD. After stopping treatmen

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https://doi.org/10.1007/s00198-018-4460-6

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Effect of Teriparatide Treatment on Circulating Periostin and Its Relationship to Regulators of Bone Formation and BMD in Postmenopausal Women With Osteoporosis

Autor: Fatma Gossiel, Richard Eastell, Eugene V. McCloskey, K. E. Naylor, Margaret Paggiosi, Nicola Peel, Jennifer Walsh, Jessica R. Scott

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 103:1302-1309

CONTEXT: Treatment of postmenopausal osteoporosis with teriparatide parathyroid hormone amino terminal 1-34 increases bone formation and improves bone microarchitecture. A possible modulator of action is periostin. In vitro experiments have shown tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120cff539d85701a797af9d418f814ee
https://doi.org/10.1210/jc.2017-00283

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Response of bone turnover markers to raloxifene treatment in postmenopausal women with osteopenia

Autor: Richard Jacques, R. Eastell, Nicola Peel, K. E. Naylor, Fatma Gossiel

Publikováno v: Europe PubMed Central

We used two methods of identifying women who reached the target for raloxifene treatment with bone turnover markers. Both approaches identified women that responded to treatment but did not fully agree and may be complementary. The change in bone tur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbbc6cf50335d47b7f021a931177780e
https://doi.org/10.1007/s00198-016-3573-z

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The effect of bisphosphosphonates on bone turnover and bone balance in postmenopausal women with osteoporosis: The T-score bone marker approach in the TRIO study

Autor: Nicola Peel, K. E. Naylor, Eugene V. McCloskey, Fatma Gossiel, Richard Eastell, Jennifer Walsh, Margaret Paggiosi

Publikováno v: Bone. 131:115158

Postmenopausal osteoporosis is characterised by increased bone turnover and an imbalance between bone resorption and formation. Bisphosphonate treatment reduces bone turnover but their effect on bone balance is yet to be fully investigated. Using the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddcc2d77ea7422b49b37aa02a182304
https://doi.org/10.1016/j.bone.2019.115158

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Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations

Publikováno v: The Journal of clinical endocrinology and metabolism, vol 103, iss 9
Schwartz, JB; Gallagher, JC; Jorde, R; Berg, V; Walsh, J; Eastell, R; et al.(2018). Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 103(9), 3278-3288. doi: 10.1210/jc.2018-00295. UCSF: Retrieved from: http://www.escholarship.org/uc/item/44w5n8qk

ContextThe optimal measure of vitamin D status is unknown.ObjectiveTo directly measure circulating free 25-hydroxyvitamin D[25(OH)D] concentrations and relationships to total 25(OH)D in a clinically diverse sample of humans.DesignCross-sectional anal

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https://escholarship.org/uc/item/44w5n8qk

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Response of bone turnover markers to three oral bisphosphonate therapies in postmenopausal osteoporosis: the TRIO study

Autor: K. E. Naylor, Margaret Paggiosi, Fatma Gossiel, Richard Jacques, Eugene V. McCloskey, R. Eastell, Jennifer Walsh, Nicola Peel

Publikováno v: Osteoporosis International. 27:21-31

Summary We used bone turnover markers to identify women who responded to bisphosphonate treatment for osteoporosis. Response was more likely with alendronate and ibandronate than risedronate. There was a greater decrease in bone markers if baseline b

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https://doi.org/10.1007/s00198-015-3145-7

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DIAGNOSIS OF ENDOCRINE DISEASE: Bone turnover markers: are they clinically useful?

Autor: Jennifer Walsh, Nicola Peel, K. E. Naylor, Tom Pigott, Fatma Gossiel, Richard Eastell

Publikováno v: European journal of endocrinology. 178(1)

Bone turnover markers (BTMs) are useful in clinical practice as they are inexpensive, and they have proven useful for treatment monitoring and identification of poor adherence. BTMs cannot be used in individual patients for identifying accelerated bo

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https://pubmed.ncbi.nlm.nih.gov/29046326

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Use of CTX-I and PINP as bone turnover markers: National Bone Health Alliance recommendations to standardize sample handling and patient preparation to reduce pre-analytical variability

Autor: N. R. Hoyle, E. T. Leary, Pawel Szulc, K. E. Naylor, R. Eastell

Publikováno v: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 28(9)

The National Bone Health Alliance (NBHA) recommends standardized sample handling and patient preparation for C-terminal telopeptide of type I collagen (CTX-I) and N-terminal propeptide of type I procollagen (PINP) measurements to reduce pre-analytica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2bf41fe616a41dc578af8d6c524d0e
https://pubmed.ncbi.nlm.nih.gov/28631236

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The effect of bisphosphonate treatment on osteoclast precursor cells in postmenopausal osteoporosis: The TRIO study

Autor: Jennifer Walsh, K. E. Naylor, R. Eastell, Nicola Peel, Christopher Hoyle, Eugene V. McCloskey, Fatma Gossiel

Publikováno v: Gossiel, F, Hoyle, C, McCloskey, E V, Naylor, K E, Walsh, J, Peel, N & Eastell, R 2016, ' The effect of bisphosphonate treatment on osteoclast precursor cells in postmenopausal osteoporosis : The TRIO study ', Bone, vol. 92, pp. 94-99 . https://doi.org/10.1016/j.bone.2016.08.010

Bisphosphonates are used to treat bone disease characterised by increased bone resorption by inhibiting the activity of mature osteoclasts, resulting in decreased bone turnover. Bisphosphonates may also reduce the population of osteoclast precursor c

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