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The Effects of Monosodium Urate Monohydrate Crystals on Chondrocyte Viability and Function: Implications for Development of Cartilage Damage in Gout

Autor: K. E. Callon, Gregory D. Gamble, Rocco P. Pitto, Jarome Bentley, Nicola Dalbeth, Bregina Pool, Fiona M McQueen, Dorit Naot, Michael Dray, Ashika Chhana, Jillian Cornish

Publikováno v: The Journal of Rheumatology. 40:2067-2074

Objective.Cartilage damage is frequently observed in advanced destructive gout. The aim of our study was to investigate the effects of monosodium urate monohydrate (MSU) crystals on chondrocyte viability and function.Methods.The alamarBlue assay and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9423a78055952102f0dd565634286ff7
https://doi.org/10.3899/jrheum.130708

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Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo

Autor: B. L. Hill, Andrew Grey, Chung-Ho Lin, Ian R. Reid, Damian E. Myers, Usha Bava, Dorit Naot, K. E. Callon, Geoffrey C. Nicholson, Jillian Cornish, Neil D. Broom

Publikováno v: Journal of Endocrinology. 175:405-415

Fat mass is an important determinant of bone density, but the mechanism of this relationship is uncertain. Leptin, as a circulating peptide of adipocyte origin, is a potential contributor to this relationship. Recently it was shown that intracerebrov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9448b635019d9f54b6f03fb6e82b6c6
https://doi.org/10.1677/joe.0.1750405

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Systemic administration of adrenomedullin(27-52) increases bone volume and strength in male mice

Autor: J, Cornish, K E, Callon, U, Bava, D H, Coy, T B, Mulvey, M A, Murray, G J, Cooper, I R, Reid

Publikováno v: Journal of Endocrinology. 170:251-257

Adrenomedullin is a 52-amino acid peptide first described in a human phaeochromocytoma but since been found to be present in many tissues, including the vascular system and bone. Because of its structural similarity to amylin and calcitonin gene-rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0da4a20e7b515521303fe94df8682d
https://doi.org/10.1677/joe.0.1700251

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Insulin Increases Histomorphometric Indices of Bone Formation In Vivo

Autor: J. Cornish, K. E. Callon, I. R. Reid

Publikováno v: Calcified Tissue International. 59:492-495

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bebb951b5e486979de48df28465e9b01
https://doi.org/10.1007/s002239900163

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Lactoferrin and bone; structure-activity relationships

Autor: J, Cornish, K, Palmano, K E, Callon, M, Watson, J M, Lin, P, Valenti, D, Naot, A B, Grey, I R, Reid

The maintenance of the mechanical integrity of the skeleton depends on bone remodeling, the well-coordinated balance between bone formation by osteoblasts and bone resorption by osteoclasts. The coupled action of osteoblasts and osteoclasts is regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::259373bc2201c4a32402c7a2a2dbe2aa
http://hdl.handle.net/11573/83883

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A potential role for adrenomedullin as a local regulator of bone growth

Autor: D, Naot, K E, Callon, A, Grey, G J, Cooper, I R, Reid, J, Cornish

Publikováno v: Endocrinology. 142(5)

Bone remodeling is a complex process of coordinated resorption and formation of bone, which is regulated by systemic hormones and by local factors. We have previously shown that the peptide hormone adrenomedullin is mitogenic to osteoblastic cells in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::90333193031faf222b281b722ce36964
https://pubmed.ncbi.nlm.nih.gov/11316750

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