Zobrazeno 1 - 10
of 411
pro vyhledávání: '"K Docherty"'
Autor:
Craig K. Docherty, Nina Denver, Simon Fisher, Margaret Nilsen, Dianne Hillyard, Rebecca L. Openshaw, Hicham Labazi, Margaret R. MacLean
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 396-405 (2020)
The 5HT1B receptor (5HT1BR) contributes to the pathogenic effects of serotonin in pulmonary arterial hypertension. Here, we determine the effect of a microRNA96 (miR96) mimic delivered directly to the lungs on development of severe pulmonary hyperten
Externí odkaz:
https://doaj.org/article/e5d263e8dc1b4639b7c47108893f55bc
Autor:
Craig K. Docherty, Anastasiya Strembitska, Christa P. Baker, Fiona F. Schmidt, Kieran Reay, John R. Mercer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 217 (2021)
The cardiovascular disease of atherosclerosis is characterised by aged vascular smooth muscle cells and compromised cell survival. Analysis of human and murine plaques highlights markers of DNA damage such as p53, Ataxia telangiectasia mutated (ATM),
Externí odkaz:
https://doaj.org/article/24832a56b1b146b3916302c802e78cef
Autor:
Joshua P. Hazelton, Anna E. Ssentongo, John S. Oh, Paddy Ssentongo, Mark J. Seamon, James P. Byrne, Isabella G. Armento, Donald H. Jenkins, Maxwell A. Braverman, Caleb Mentzer, Guy C. Leonard, Lindsey L. Perea, Courtney K. Docherty, Julie A. Dunn, Brittany Smoot, Matthew J. Martin, Jayraan Badiee, Alejandro J. Luis, Julie L. Murray, Matthew R. Noorbakhsh, James E. Babowice, Charles Mains, Robert M. Madayag, Haytham M.A. Kaafarani, Ava K. Mokhtari, Sarah A. Moore, Kathleen Madden, Allen Tanner, Diane Redmond, David J. Millia, Amber Brandolino, Uyen Nguyen, Vernon Chinchilli, Scott B. Armen, John M. Porter
Publikováno v:
Annals of Surgery. 276:579-588
The aim of this study was to identify a mortality benefit with the use of whole blood (WB) as part of the resuscitation of bleeding trauma patients.Blood component therapy (BCT) is the current standard for resuscitating trauma patients, with WB emerg
Autor:
Craig K. Docherty, Jordan Bresciani, Andy Carswell, Amrita Chanderseka, Elaine Friel, Marianna Stasi, John R. Mercer
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9993 (2021)
DNA damage and mitochondrial dysfunction are defining characteristics of aged vascular smooth muscle cells (VSMCs) found in atherosclerosis. Pink1 kinase regulates mitochondrial homeostasis and recycles dysfunctional organelles critical for maintaini
Externí odkaz:
https://doaj.org/article/05b5d846ea8549f28445a661251b6db4
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 5 (2019)
Background Women are at greater risk of developing pulmonary arterial hypertension, with estrogen and its downstream metabolites playing a potential role in the pathogenesis of the disease. Hypoxia‐inducible factor‐1‐α (HIF1α) is a pro‐prol
Externí odkaz:
https://doaj.org/article/60705a9fce674838a45d67b5e1c30a50
Akademický článek
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Autor:
Craig K. Docherty, Anastasiya Strembitska, Christa P. Baker, Fiona F. Schmidt, Kieran Reay, John R. Mercer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 217, p 217 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 217
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 217
The cardiovascular disease of atherosclerosis is characterised by aged vascular smooth muscle cells and compromised cell survival. Analysis of human and murine plaques highlights markers of DNA damage such as p53, Ataxia telangiectasia mutated (ATM),
Publikováno v:
Atmospheric Chemistry and Physics, Vol 14, Iss 24, Pp 13681-13704 (2014)
Secondary organic aerosol (SOA) was generated by irradiating 1,3-butadiene (13BD) in the presence of H2O2 or NOx. Experiments were conducted in a smog chamber operated in either flow or batch mode. A filter/denuder sampling system was used for simult
Externí odkaz:
https://doaj.org/article/46cea2d777f847c48f43ad9e56a29c41
Autor:
N. H. Robinson, J. F. Hamilton, J. D. Allan, B. Langford, D. E. Oram, Q. Chen, K. Docherty, D. K. Farmer, J. L. Jimenez, M. W. Ward, C. N. Hewitt, M. H. Barley, M. E. Jenkin, A. R. Rickard, S. T. Martin, G. McFiggans, H. Coe
Publikováno v:
Atmospheric Chemistry and Physics, Vol 11, Iss 3, Pp 1039-1050 (2011)
Isoprene is the most abundant non-methane biogenic volatile organic compound (BVOC), but the processes governing secondary organic aerosol (SOA) formation from isoprene oxidation are only beginning to become understood and selective quantification of
Externí odkaz:
https://doaj.org/article/c4ab9deca22a4b9b95cd1b3fa659c080
Autor:
John Mercer, Craig K. Docherty, Jordan Bresciani, Andrew Carswell, Amrita Chanderseka, Marianna Stasi, E Friel
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9993, p 9993 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 18
International Journal of Molecular Sciences
Volume 22
Issue 18
DNA damage and mitochondrial dysfunction are defining characteristics of aged vascular smooth muscle cells (VSMCs) found in atherosclerosis. Pink1 kinase regulates mitochondrial homeostasis and recycles dysfunctional organelles critical for maintaini