Výsledky vyhledávání

Akademický článek

Open questions in human lung organoid research

Autor: Tessa Hughes, Krijn K. Dijkstra, Emma L. Rawlins, Robert E. Hynds

Publikováno v: Frontiers in Pharmacology, Vol 13 (2023)

Organoids have become a prominent model system in pulmonary research. The ability to establish organoid cultures directly from patient tissue has expanded the repertoire of physiologically relevant preclinical model systems. In addition to their deri

Externí odkaz: https://doaj.org/article/b651e0950c3b4330b130e47cf7e32e44

Zobrazit plný text záznamu

Akademický článek

Performance of acute respiratory distress syndrome definitions in a high acuity paediatric intensive care unit

Autor: Michelle Rudolph, Jefta van Dijk, Pauline de Jager, Sandra K. Dijkstra, Johannes G. M. Burgerhof, Robert G. T. Blokpoel, Martin C. J. Kneyber

Publikováno v: Respiratory Research, Vol 22, Iss 1, Pp 1-12 (2021)

Abstract Background For years, paediatric critical care practitioners used the adult American European Consensus Conference (AECC) and revised Berlin Definition (BD) for acute respiratory distress syndrome (ARDS) to study the epidemiology of paediatr

Externí odkaz: https://doaj.org/article/e0f70f59b27944a381c163860dfecde3

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Feasibility of an alternative, physiologic, individualized open-lung approach to high-frequency oscillatory ventilation in children

Autor: Pauline de Jager, Tamara Kamp, Sandra K. Dijkstra, Johannes G. M. Burgerhof, Dick G. Markhorst, Martha A. Q. Curley, Ira M. Cheifetz, Martin C. J. Kneyber

Publikováno v: Annals of Intensive Care, Vol 9, Iss 1, Pp 1-13 (2019)

Abstract Background High-frequency oscillatory ventilation (HFOV) is a common but unproven management strategy in paediatric critical care. Oscillator settings have been traditionally guided by patient age and/or weight rather than by lung mechanics,

Externí odkaz: https://doaj.org/article/f2eef0b304b8451dbf86c2a317575704

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma

Autor: Krijn K. Dijkstra, José G. van den Berg, Fleur Weeber, Joris van de Haar, Arno Velds, Sovann Kaing, Dennis D. G. C. Peters, Ferry A. L. M. Eskens, Derk-Jan A. de Groot, Margot E. T. Tesselaar, Emile E. Voest

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

Gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) is a poorly understood disease with limited treatment options. A better understanding of this disease would greatly benefit from the availability of representative preclinical models. Here, we

Externí odkaz: https://doaj.org/article/737cc6a2352e4ea98121176d9873021f

Zobrazit plný text záznamu

Akademický článek

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine

Autor: Krijn K. Dijkstra, Kim Monkhorst, Luuk J. Schipper, Koen J. Hartemink, Egbert F. Smit, Sovann Kaing, Rosa de Groot, Monika C. Wolkers, Hans Clevers, Edwin Cuppen, Emile E. Voest

Publikováno v: Cell Reports, Vol 31, Iss 5, Pp - (2020)

Summary: Clinical implementation of tumor organoids for personalized medicine requires that pure tumor organoids can be reliably established. Here, we present our experience with organoid cultures from >70 non-small cell lung cancer (NSCLC) samples.

Externí odkaz: https://doaj.org/article/b469827b6c1c427c86f583c772baa165

Zobrazit plný text záznamu

Akademický článek

Confirmatory Composite Analysis

Autor: Florian Schuberth, Jörg Henseler, Theo K. Dijkstra

Publikováno v: Frontiers in Psychology, Vol 9 (2018)

This article introduces confirmatory composite analysis (CCA) as a structural equation modeling technique that aims at testing composite models. It facilitates the operationalization and assessment of design concepts, so-called artifacts. CCA entails

Externí odkaz: https://doaj.org/article/2ce73f82d31d48daa72d254a44900f61

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání