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Effects of heavy ions and energetic protons on normal human fibroblasts

Publikováno v: Radiatsionnaia biologiia, radioecologiia. 47(3)

At the low particle fluences of radiation to which astronauts are exposed in space, "non-targeted" effects such as the bystander response may have increased significance. The radiation-induced bystander effect is the occurrence of biological response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2f7f1b15164ca31b3d0ea4006f0d6a55
https://pubmed.ncbi.nlm.nih.gov/17867499

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Progress Toward Fast Neutron Relative Biological Effectiveness Determination Via Proton Bombardment of V79 Cells

Autor: Jacquelyn C. Yanch, Haijun Song, M. A. Sitek, R. E. Klinkowstein, K. D. Held

Publikováno v: Frontiers in Neutron Capture Therapy ISBN: 9781461354789

Conclusive data relating to the relative biological effectiveness (RBE) of the fast neutrons encountered in neutron capture therapies are limited. At the Massachusetts Institute of Technology’s (MIT) Laboratory for Accelerator Beam Applications (LA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::030ef37ad4f2a6ced54d6509c71793e3
https://doi.org/10.1007/978-1-4615-1285-1_109

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Coumarin-3-carboxylic acid as a detector for hydroxyl radicals generated chemically and by gamma radiation

Autor: Y, Manevich, K D, Held, J E, Biaglow

Publikováno v: Radiation research. 148(6)

Coumarin-3-carboxylic acid (3-CCA) was used as a detector for hydroxyl radicals (.OH) in aqueous solution. The .OH was generated by gamma irradiation or chemically by the Cu2+-mediated oxidation of ascorbic acid (ASC). The excitation and emission spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a47a2ae3947d5641083adcab577af0f
https://pubmed.ncbi.nlm.nih.gov/9399704

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Caffeine-induced apoptosis reveals a persistent lesion after treatment with bromodeoxyuridine and ultraviolet-B light

Autor: M P, Hagan, K L, Hopcia, F C, Sylvester, K D, Held

Publikováno v: Radiation research. 147(6)

Ultraviolet-B (UVB) light treatment of synchronized V79 Chinese hamster cells after pulse-labeling with bromodeoxyuridine (BrdUrd) reveals a marked age response for cell killing. Incubation after treatment in growth medium containing caffeine increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15eadd19e7923b46719fca5c81fec015
https://pubmed.ncbi.nlm.nih.gov/9189164

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Mechanism of production of hydroxyl radicals in the copper-catalyzed oxidation of dithiothreitol

Autor: A V, Kachur, K D, Held, C J, Koch, J E, Biaglow

Publikováno v: Radiation research. 147(4)

We have undertaken detailed studies of the mechanisms involved in the production of OH radicals during the copper-catalyzed oxidation of dithiothreitol (DTT). Most of these studies were conducted in real time, detecting .OH based on its reaction with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::73bcf24d803e3bb401ee586ea42ca055
https://pubmed.ncbi.nlm.nih.gov/9092919

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Role of guanosine triphosphate in ferric ion-linked Fenton chemistry

Autor: J E, Biaglow, K D, Held, Y, Manevich, S, Tuttle, A, Kachur, F, Uckun

Publikováno v: Radiation research. 145(5)

We measured the production of reactive hydroxyl radical (OH.) by Fe2+ itself or complexed with nucleotide triphosphates or tripolyphosphate (TPP). Coumarin-3-carboxylic acid (3-CCA) reacts with the OH. produced by Fe2+, Fe3+ or Cu2+ plus ascorbate an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::43834bd97e8bc777858877af2d894d61
https://pubmed.ncbi.nlm.nih.gov/8619020

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Role of Fenton chemistry in thiol-induced toxicity and apoptosis

Autor: K D, Held, F C, Sylvester, K L, Hopcia, J E, Biaglow

Publikováno v: Radiation research. 145(5)

Under certain conditions, many radioprotective thiols can be toxic, causing loss of colony-forming ability in cultured mammalian cells in a biphasic fashion whereby the thiols are not toxic at high or low concentrations of the drug, but cause decreas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::852212202fd02a35ed269cb15b57fced
https://pubmed.ncbi.nlm.nih.gov/8619019

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