Výsledky vyhledávání

EphrinB2 Regulation by PTH and PTHrP Revealed by Molecular Profiling in Differentiating Osteoblasts

Autor: Tao Wei, J.M.W. Quinn, Jonathan H. Gooi, S. Pompolo, Natalie A. Sims, Matthew T. Gillespie, K D Hausler, Blessing Crimeen-Irwin, Jude E. Onyia, E H Allan, T. John Martin

Publikováno v: Journal of Bone and Mineral Research. 23:1170-1181

With the aim of identifying new pathways and genes regulated by PTH(1-34) and PTH-related protein 1-141 [PTHrP(1-141)] in osteoblasts, this study was carried out using a mouse marrow stromal cell line, Kusa 4b10, that acquires features of the osteobl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6fc8ea44837ce6898f9b82f4ca31b9
https://doi.org/10.1359/jbmr.080324

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RARγ is a negative regulator of osteoclastogenesis

Autor: Ingrid J Poulton, Carl R. Walkley, Louise E. Purton, Joy Y. Wu, Julian M.W. Quinn, K D Hausler, T. John Martin, Roshantha A.S. Chandraratna, Natalie A. Sims, Matthew T. Gillespie, Alanna C. Green, Christina Vrahnas

Vitamin A is known to influence post-natal bone content, with excess intake being associated with reduced bone mineral density and increased fracture risk. Despite this, the roles retinoids play in regulating osteoclastogenesis, particularly in vivo,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4fad3fa1d1faaa585dc1297f1242e9a
https://acuresearchbank.acu.edu.au/item/8778w/rar-is-a-negative-regulator-of-osteoclastogenesis

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Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation

Autor: T. John Martin, Matthew T. Gillespie, Yoshiro Chuman, J Ellis, K D Hausler, Nicole J. Horwood, Jane L. Fisher, Jeffrey S. Rubin

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 19(11)

We determined that sFRP-1 mRNA was differentially expressed by osteoblast/stromal cell lines and that sFRP-1 neutralizing antibodies and siRNA complementary to sFRP-1 coding sequence enhanced, while recombinant sFRP-1 inhibited, osteoclast formation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f574e0acb24ed619502e767cce1f0d5
http://ora.ox.ac.uk/objects/uuid:c8e8d612-96f2-41a8-95c1-d226aae499f0

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Transforming growth factor beta affects osteoclast differentiation via direct and indirect actions

Autor: Julian M.W. Quinn, Thomas J. Martin, K. Itoh, Kanji Higashio, Matthew T. Gillespie, K D Hausler, Atsuko Mizuno, Tatsuo Suda, H. Yasuda, Nobuyuki Udagawa, N. Takahashi, N. Shima

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 16(10)

Transforming growth factor beta (TGF-beta) is abundant in bone and has complex effects on osteolysis, with both positive and negative effects on osteoclast differentiation, suggesting that it acts via more than one mechanism. Osteoclastogenesis is de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161734ca27fde60dfd566f4d1132b279
https://pubmed.ncbi.nlm.nih.gov/11585342

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