Zobrazeno 1 - 10
of 190
pro vyhledávání: '"K D Bagshawe"'
Autor:
K. D. Bagshawe
Publikováno v:
Drug Development Research. 34:220-230
Many of the limitations of conventional cytotoxic chemotherapy and of attempts to achieve selectivity using antibody vectors can be overcome by a 2 or 3 stage prodrug system. An antibody vectors to tumour sites an enzyme that is not normally present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::673f205f1667ef0e471540e69a22611d
https://doi.org/10.1002/ddr.430340211
https://doi.org/10.1002/ddr.430340211
Publikováno v:
Annals of Oncology. 5:879-891
The concept of generating cytotoxic agents from non-toxic prodrugs at tumour sites by antibody vectored enzyme introduces a wide range of opportunities. Various prodrug-enzyme combinations have been described and encouraging results reported in xenog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37c0b16408f4fb2681b070934a6fec11
https://doi.org/10.1093/oxfordjournals.annonc.a058725
https://doi.org/10.1093/oxfordjournals.annonc.a058725
Autor:
K. D. Bagshawe
Publikováno v:
Cell Biophysics. :83-91
Antibody-based therapy has attracted interest because of its potential to improve selectivity. But the limitations of antibodies as delivery systems are well known and the objective of restricting action to tumor sites requires additional means. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43a99b6f55c400f470ee899ca980d71
https://doi.org/10.1007/bf02789218
https://doi.org/10.1007/bf02789218
Autor:
K D, Bagshawe
Publikováno v:
Proceedings of the Royal Society of Medicine. 67(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3854f2124763d38f3a066db5e1e30f9b
https://pubmed.ncbi.nlm.nih.gov/20919171
https://pubmed.ncbi.nlm.nih.gov/20919171
Autor:
K. D. Bagshawe
Publikováno v:
Ciba Foundation Symposium 96-Fetal Antigens and Cancer ISBN: 9780470720776
Ciba Foundation Symposium 96-Fetal Antigens and Cancer
Ciba Foundation Symposium 96-Fetal Antigens and Cancer
Human chorionic gonadotropin (hCG) has an important biological function and has clinical use as a hormone, yet its applications as an antigen are also numerous. Pregnancy tests have brought immunological reactions into the high street pharmacy and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7020ef261bec2dffd67a44c21504c5c3
https://doi.org/10.1002/9780470720776.ch9
https://doi.org/10.1002/9780470720776.ch9
Publikováno v:
The British Journal of Radiology. 63:942-945
Ultrasound imaging of the uterus and ovaries was performed on 41 patients after completion of apparently successful cytotoxic chemotherapy for invasive mole and choriocarcinoma. Uterine volume was calculated and the echopattern of the uterus and ovar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e4270a54e9fc1258c699e63ec86103
https://doi.org/10.1259/0007-1285-63-756-942
https://doi.org/10.1259/0007-1285-63-756-942
Autor:
K. D. Bagshawe, M. Napier
Publikováno v:
Enzyme-Prodrug Strategies for Cancer Therapy ISBN: 9781461371861
Although much experience had been gained with the agents available for ADEPT studies in xenografted mice (Bagshawe et al., 1988), their translation into the clinic was in many ways a step into the unknown. It seemed possible, even likely, that new an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a052656fe947f00c7fd3891df2f7b6c
https://doi.org/10.1007/978-1-4615-4823-2_8
https://doi.org/10.1007/978-1-4615-4823-2_8
Autor:
E S, Newlands, M, Bower, L, Holden, D, Short, M J, Seckl, G J, Rustin, R H, Begent, K D, Bagshawe
Publikováno v:
The Journal of reproductive medicine. 43(2)
To analyze the causes of therapeutic success and failure in the management of patients with high-risk gestational trophoblastic tumors (GTTs).Analysis of 272 consecutive high-risk patients treated at the trophoblastic disease center at the Charing Cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7546ba2ae8081a3e9702e9a9f777b722
https://pubmed.ncbi.nlm.nih.gov/9513872
https://pubmed.ncbi.nlm.nih.gov/9513872