Zobrazeno 1 - 10
of 60
pro vyhledávání: '"K D, Watenpaugh"'
Autor:
Martin R. Deibel, Constance G Chidester, Cindy L Wolfe, K. D. Watenpaugh, Anthony W. Yem, Ross Reynolds
Publikováno v:
Journal of Molecular Biology. 293:559-568
Cdc25B is a dual specificity phosphatase involved in the control of cyclin-dependent kinases and the progression of cells through the cell cycle. A series of minimal domain Cdc25B constructs maintaining catalytic activity have been expressed. The str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90ac8adfe9c2ebf80b9644ad70d3c824
https://doi.org/10.1006/jmbi.1999.3168
https://doi.org/10.1006/jmbi.1999.3168
Publikováno v:
Biochemical and Biophysical Research Communications. 259:420-428
Tau protein kinase II (TPKII) is a heterodimer comprising a catalytic cyclin-dependent kinase subunit (Cdk5) and a regulatory protein called neuronal Cdk5 activator (Nck5a). TPKII is somewhat reminiscent, therefore, of the Cdk2-cyclin complex importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086c50106b21c97cdd44dc7698f694f8
https://doi.org/10.1006/bbrc.1999.0792
https://doi.org/10.1006/bbrc.1999.0792
Autor:
Lester A. Dolak, Johnson Paul D, Chong Kt, Harvey Irving Skulnick, Paul K. Tomich, Michael John Bohanon, Strohbach Joseph Walter, Suvit Thaisrivongs, Steve Turner, K. D. Watenpaugh, M.‐M. Horng, M.N. Janakiraman, R. R. Hinshaw, Paul A. Aristoff, J. C. Lynn, Eric P. Seest, Tommasi Ruben A
Publikováno v:
Journal of Medicinal Chemistry. 41:3467-3476
A broad screening program previously identified phenprocoumon (1) as a small molecule template for inhibition of HIV protease. Subsequent modification of this lead through iterative cycles of structure-based design led to the activity enhancements of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb61de09a28125894737f3e08843301
https://doi.org/10.1021/jm9802158
https://doi.org/10.1021/jm9802158
Autor:
Suvit Thaisrivongs, Tommasi Ruben A, Chong Kt, K. D. Watenpaugh, Paul K. Tomich, Strohbach Joseph Walter, Steve R. Turner, M.N. Janakiraman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:1237-1242
Potent, non-peptidic, dihydropyrone sulfonamide HIV protease inhibitors have been previously described. Crystallographic analysis of dihydropyrone sulfonamide inhibitor/HIV protease complexes suggested incorporation of a second, C2 symmetry-related s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0930ad82487dc9e58716b84d5a31f557
https://doi.org/10.1016/s0960-894x(98)00197-8
https://doi.org/10.1016/s0960-894x(98)00197-8
Autor:
J. C. Lynn, Tommasi Ruben A, Johnson Paul D, Strohbach Joseph Walter, R. R. Hinshaw, M.N. Janakiraman, Chong Kt, Turner, Paul A. Aristoff, Morge Rr, Howe Wj, Tomich Pk, Donna L. Romero, M.‐M. Horng, Barry C. Finzel, Carolyn Biles, K. D. Watenpaugh, Suvit Thaisrivongs
Publikováno v:
Journal of Medicinal Chemistry. 39:4630-4642
From a broad screening program, the 4-hydroxycoumarin phenprocoumon (I) was previously identified as a lead template with HIV protease inhibitory activity. The crystal structure of phenprocoumon/HIV protease complex initiated a structure-based design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2825cd7d8c44b64d6d1c8790f32737
https://doi.org/10.1021/jm960228q
https://doi.org/10.1021/jm960228q
Autor:
S, Thaisrivongs, M N, Janakiraman, K T, Chong, P K, Tomich, L A, Dolak, S R, Turner, J W, Strohbach, J C, Lynn, M M, Horng, R R, Hinshaw, K D, Watenpaugh
Publikováno v:
Journal of Medicinal Chemistry. 39:2400-2410
The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents. Our broad screening program to discover non-peptidic HIV protease inhibitors previously id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe175551c1e0beaead1087dbbcdb75b9
https://doi.org/10.1021/jm950888f
https://doi.org/10.1021/jm950888f
Autor:
L. F. Ten Eyck, K. D. Watenpaugh
Publikováno v:
International Tables for Crystallography ISBN: 9780470660782
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8df30c5795d12372a23ebb9cc396195e
https://doi.org/10.1107/97809553602060000855
https://doi.org/10.1107/97809553602060000855
Autor:
Turner, Chong Kt, K. D. Watenpaugh, Howe Wj, Tomich Pk, Yang Cp, McGrath Jp, Michael John Bohanon, Strohbach Joseph Walter, Suvit Thaisrivongs
Publikováno v:
Journal of Medicinal Chemistry. 37:3200-3204
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf9d7601d1f72097120841f3496ff49
https://doi.org/10.1021/jm00046a002
https://doi.org/10.1021/jm00046a002
Autor:
A. M. Mulichak, A G Tomasselli, Suvit Thaisrivongs, Robert L. Heinrikson, K. A. Curry, J. O. Hui, Che-Shen C. Tomich, K. D. Watenpaugh, Tomi K. Sawyer
Publikováno v:
Journal of Biological Chemistry. 268:13103-13109
The crystal structure of human immunodeficiency virus (HIV) type 2 protease has been determined in complexes with peptidic inhibitors Noa-His-Cha psi [CH(OH)CH(OH)]Val-Ile-Amp (U75875) and Qnc-Asn-Cha psi [CH(OH)CH2]Val-Npt(U92163) (where Noa is naph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b4c773816a95a264f124b6c94ef5537
https://doi.org/10.1016/s0021-9258(19)38625-9
https://doi.org/10.1016/s0021-9258(19)38625-9
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 49:100-106
Xtal3.2, a crystallographic software package, is an international development project involving about 40 researchers over a full spectrum of crystallographic interests. This development has been supported by many national and international agencies a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae0901ec0b119fc46e09268cff9eaa1
https://doi.org/10.1107/s0907444992008898
https://doi.org/10.1107/s0907444992008898