Zobrazeno 1 - 10
of 375
pro vyhledávání: '"K Craig, Kent"'
Autor:
Nisakorn Yodsanit, Takuro Shirasu, Yitao Huang, Li Yin, Zain Husain Islam, Alexander Christopher Gregg, Alessandra Marie Riccio, Runze Tang, Eric William Kent, Yuyuan Wang, Ruosen Xie, Yi Zhao, Mingzhou Ye, Jingcheng Zhu, Yi Huang, Nicholas Hoyt, Mengxue Zhang, John A. Hossack, Morgan Salmon, K. Craig Kent, Lian-Wang Guo, Shaoqin Gong, Bowen Wang
Publikováno v:
Bioactive Materials, Vol 26, Iss , Pp 52-63 (2023)
Abdominal aortic aneurysm (AAA) is a progressive aortic dilatation, causing ∼80% mortality upon rupture. Currently, there is no approved drug therapy for AAA. Surgical repairs are invasive and risky and thus not recommended to patients with small A
Externí odkaz:
https://doaj.org/article/06a3c43ca58a4786b5837224f457fa48
Autor:
Mengxue Zhang, Jing Li, Qingwei Wang, Go Urabe, Runze Tang, Yitao Huang, Jose Verdezoto Mosquera, K. Craig Kent, Bowen Wang, Clint L. Miller, Lian-Wang Guo
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 717-729 (2023)
Epigenetically switched, proliferative vascular smooth muscle cells (SMCs) form neointima, engendering stenotic diseases. Histone-3 lysine-27 trimethylation (H3K27me3) and acetylation (H3K27ac) marks are associated with gene repression and activation
Externí odkaz:
https://doaj.org/article/9b065267a6a6463fa7b9506f5322e25e
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Neointimal hyperplasia (IH) is a common vascular pathology that typically manifests in in-stent restenosis and bypass vein graft failure. Smooth muscle cell (SMC) phenotypic switching is central to IH, both regulated by some microRNAs, yet t
Externí odkaz:
https://doaj.org/article/0995f48040b245f3a1e278c0598d7b3d
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract Endothelial cell (EC) and smooth muscle cell (SMC) are major cell types adjacent in the vascular wall. Recent progress indicates that their communication is crucial for vascular homeostasis and pathogenesis. In particular, dysfunctional (pro
Externí odkaz:
https://doaj.org/article/a474cb47b6624d54be799f152e285a6c
Publikováno v:
Atherosclerosis Plus, Vol 44, Iss , Pp 31-42 (2021)
Background: Vascular smooth muscle cell (SMC) apoptosis is involved in major cardiovascular diseases. Smad2 is a transcription factor implicated in aortic aneurysm. The molecular mediators of Smad2-driven SMC apoptosis are not well defined. Here we h
Externí odkaz:
https://doaj.org/article/bd1c150c014c4f97a908b6935c939720
Autor:
Qingwei Wang, Hatice Gulcin Ozer, Bowen Wang, Mengxue Zhang, Go Urabe, Yitao Huang, K. Craig Kent, Lian-Wang Guo
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 54-66 (2021)
Bromodomain protein BRD4 reads histone acetylation (H3K27ac), an epigenomic mark of transcription enhancers. CCAAT enhancer binding protein delta (CEBPD) is a transcription factor typically studied in metabolism. While both are potent effectors and p
Externí odkaz:
https://doaj.org/article/c4501990cf32428e9ba19ad13169e516
Autor:
Mengxue Zhang, MD, MS, Go Urabe, MD, PhD, Christopher Little, MD, Bowen Wang, PhD, Alycia M. Kent, Yitao Huang, BS, K. Craig Kent, MD, Lian-Wang Guo, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 782-795 (2018)
Summary: Cellular plasticity is fundamental in biology and disease. Vascular smooth muscle cell (SMC) dedifferentiation (loss of contractile proteins) initiates and perpetrates vascular pathologies such as restenosis. Contractile gene expression is g
Externí odkaz:
https://doaj.org/article/eb965fd2fd8941829d2592e8050ff907
Autor:
Sarah Franco, Amelia Stranz, Fiona Ljumani, Go Urabe, Mirnal Chaudhary, Danielle Stewart, Vijaya Satish Pilli, Matthew Kelly, Dai Yamanouchi, K. Craig Kent, Bo Liu
Publikováno v:
Heliyon, Vol 6, Iss 6, Pp e04028- (2020)
Background: Accelerated smooth muscle cell (SMC) proliferation is the primary cause of intimal hyperplasia (IH) following vascular interventions. Forkhead Box M1 (FOXM1) is considered a proliferation-associated transcription factor. However, the pres
Externí odkaz:
https://doaj.org/article/901a56035cca40f1bc2f57010062a885
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 8 (2020)
Background Vascular smooth muscle cell phenotypic change and consequential intimal hyperplasia (IH) cause arterial stenosis and posttreatment restenosis. Smad3 is a master transcription factor, yet its underlying functional mechanisms in this disease
Externí odkaz:
https://doaj.org/article/d1868cb3d57f4377aeed9111879b6da1
Autor:
Takuro Shirasu, W. Bowen, Nisakorn Yodsanit, Mengxue Zhang, Yitao Huang, Shaoqin S. Gong, Lianwang Guo, K. Craig Kent
Publikováno v:
JVS - Vascular Science, Vol 2, Iss , Pp 284-285 (2021)
Externí odkaz:
https://doaj.org/article/45738980753c454e871538e0174989a1