On‐demand treatment with the iron chelator deferasirox is ineffective in preventing blood‐induced joint damage in haemophilic mice

Autor: Lize F D van Vulpen, K. Coeleveld, Roger E. G. Schutgens, Astrid E Pulles, Floris P J G Lafeber, Simon C. Mastbergen

Publikováno v: Haemophilia

Introduction Early intervention in the devastating process of haemophilic arthropathy (HA) is highly desirable, but no disease‐modifying therapy is currently available. Considering the pivotal role of iron in the development of HA, iron chelation i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0c285c8dc9e7755e787160198c2d75
http://europepmc.org/articles/PMC8361985

Proteoglycan synthesis rate as a novel method to measure blood‐induced cartilage degeneration in non‐haemophilic and haemophilic rats

Autor: Astrid E Pulles, Kirstine Roepstorff, K. Coeleveld, Floris P J G Lafeber, Roger E. G. Schutgens, Simon C. Mastbergen, Kristine Rothaus Christensen, Axel Kornerup Hansen, Kåre Kryger Vøls, Mads Kjelgaard-Hansen, Maj Petersen, Lize F D van Vulpen

Publikováno v: Haemophilia
Pulles, A E, Vøls, K K, Christensen, K R, Coeleveld, K, Hansen, A K, van Vulpen, L F D, Petersen, M, Mastbergen, S C, Roepstorff, K, Schutgens, R E G, Kjelgaard-Hansen, M & Lafeber, F P J G 2020, ' Proteoglycan synthesis rate as a novel method to measure blood-induced cartilage degeneration in non-haemophilic and haemophilic rats ', Haemophilia, vol. 26, no. 3, pp. e88-e96 . https://doi.org/10.1111/hae.13969

Introduction: Haemophilic animal models are used to study blood-induced cartilage damage, but quantitative and sensitive outcome measures are needed. Aim: To develop a novel quantitative method for detecting early cartilage degeneration in a haemophi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe1293415af2b2d5a25d0339514b52a
https://doi.org/10.1111/hae.13969

Groove model of tibia-femoral osteoarthritis in the rat

Autor: Huub M. de Visser, Mattie H.P. van Rijen, K. Coeleveld, Simon C. Mastbergen, Floris P J G Lafeber, Harrie Weinans

Publikováno v: Journal of Orthopaedic Research. 35:496-505

Several experimental models of osteoarthritis in rats are used to study the pathophysiology of osteoarthritis. Many mechanically induced models have the limitation that permanent joint instability is induced by, for example, ligament transection or m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d56b4bc6c0ac3b70570d1e8ce97f9df
https://doi.org/10.1002/jor.23299

OP0262 Disease modifying effects of the canine il4–10 fusion protein in the canine groove model of osteoarthritis

Autor: EM Van Helvoort, F.P.J.G. Lafeber, S.C. Mastbergen, J. Popov-Celeketic, K. Coeleveld, Marianna A. Tryfonidou, C. D. Wijne, A. Doornenbal

Publikováno v: FRIDAY, 15 JUNE 2018.

Background An ideal disease modifying osteoarthritis (OA) drug should have analgesic, chondroprotective and anti-inflammatory effects. A fusion protein of Interleukin 4 and 10 (IL4–10FP) might have these effects. Objectives This study evaluates the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ff94dcc3bfa68fcd5f6cc227fb65dc3
https://doi.org/10.1136/annrheumdis-2018-eular.1665

FRI0008 Effects of the human il4-10 fusion protein in the canine groove model of osteoarthritis

Autor: Marianna A. Tryfonidou, J. Popov-Celeketic, K. Coeleveld, F.P.J.G. Lafeber, EM Van Helvoort, S.C. Mastbergen

Publikováno v: Poster Presentations.

Background Ideally a disease modifying osteoarthritis drug (DMOAD) combines treatment for pain, tissue damage and inflammation, all in one molecule. Intra-articular application of a DMOAD brings additional value to treatment for two reasons, (i) lowe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60bf52503e30d9ecca29f960fe71ab53
https://doi.org/10.1136/annrheumdis-2017-eular.1498