Zobrazeno 1 - 10 of 272 pro vyhledávání: '"K C Gatter"'
1
JMY protein, a regulator of P53 and cytoplasmic actin filaments, is expressed in normal and neoplastic tissues
Autor: Omanma Adighibe, N B La Thangue, K C Gatter, R Leek, Helen Turley, Amanda S. Coutts, Adrian L. Harris, Francesco Pezzella
Publikováno v: Virchows Archiv. 465:715-722
JMY is a p300-binding protein with dual action: by enhancing P53 transcription in the nucleus, it plays an important role in the cellular response to DNA damage, while by promoting actin filament assembly in the cytoplasm; it induces cell motility in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135744f5a37e38845061cd5d4b6c58ff
https://doi.org/10.1007/s00428-014-1660-0
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2
Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues
Autor: Christopher W. Pugh, Ya-Min Tian, H Turley, Adrian L. Harris, Elizabeth J. Soilleux, K C Gatter
Aims The cellular response to hypoxia includes the hypoxia inducible factor (HIF)-induced transcription of genes involved in diverse processes such as glycolysis, angiogenesis and the growth of experimental tumours. Regulation of the level of hypoxia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f48ace97d786d599800cbaa5cfb68bd
https://ora.ox.ac.uk/objects/uuid:cd2b6c29-9413-46a0-b1bf-4a6dcb67f384
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3
The prognostic value of quantitative angiogenesis in breast cancer and role of adhesion molecule expression in tumor endothelium
Autor: R Leek, R. M. Whitehouse, Gareth D. H. Turner, K C Gatter, Stephen B. Fox, Adrian L. Harris
Angiogenesis is the formation of new capillaries from the existing vascular network and is essential for tumor growth and metastases. Increased microvessel density in breast cancer is associated with lymph node metastasis and reduced survival. We hav
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf7dbf94af32b69e816ca539fae7d5a
https://doi.org/10.1007/bf00666042
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4
Mutations in the p53 gene are not limited to classic 'hot spots' and are not predictive of p53 protein expression in high-grade non-Hodgkin's lymphoma
Autor: S Laha, Margaret Jones, D Y Mason, K C Gatter, Adrian L. Harris, S Kocialkowski, H Morrison, Francesco Pezzella
Publikováno v: Scopus-Elsevier
We have investigated the relationship between the p53 genotype and phenotype in a series of 22 high-grade non-Hodgkin's lymphomas (NHLs) in which we sequenced the p53 gene open reading frame (exons 2-11). Immunostaining for p53 was already available
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de48ba9437ce84956fcf2b801577cade
https://doi.org/10.1111/j.1365-2141.1995.tb08911.x
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5
Crypt cell proliferation and HLA-DR expression in pelvic ileal pouches
Autor: K C Gatter, H.J. de Silva, Derek P. Jewell, Michael G. W. Kettlewell, Neil Mortensen, P R Millard
To investigate the nature of the morphological changes that occur in ileal pouches, 26 biopsy specimens from patients with functioning ileo-anal pouches (eight with pouchitis) were studied. Normal ileum (n = 10) was used as a control. Mucosal morphom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273f0054c51dc964cbda746b62e7fd7a
https://ora.ox.ac.uk/objects/uuid:1f196cb5-6f7c-4db3-8951-d46ddc775bcc
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7
Vascular density analysis in colorectal cancer patients treated with vatalanib (PTK787/ZK222584) in the randomised CONFIRM trials
Autor: D Laurent, M I Koukourakis, M. Shi, David Lebwohl, Adrian L. Harris, Gerold Meinhardt, Alexandra Giatromanolaki, Gunnar Folprecht, Efthimios Sivridis, Tanja Trarbach, K C Gatter, T Jalava
Publikováno v: British Journal of Cancer
Background: Pharmacological inhibitors of vascular endothelial growth factor (VEGF) receptors, like vatalanib, have been tested in randomised trials (CONFIRM (Colorectal Oral Novel therapy For the Inhibition of Angiogenesis and Retarding of Metastase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ce239b53ec51d563057147c62894ad
https://doi.org/10.1038/bjc.2012.369
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8
Hypoxia inducible factors 1alpha and 2alpha are associated with VEGF expression and angiogenesis in gallbladder carcinomas
Autor: Efthimios Sivridis, Alexandra Giatromanolaki, M I Koukourakis, Alexandros Polychronidis, Adrian L. Harris, C. Simopoulos, K C Gatter
Aims To investigate the significance of the hypoxia inducible factors HIF-1α and HIF-2α in gallbladder adenocarcinomas and their relation to angiogenesis and to the expression of VEGF, an angiogenic factor transcriptionally regulated by HIFαs. Met
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9299d4da73c83c70ce915c9cfabd2ec
https://doi.org/10.1002/jso.20443
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9
Thymidine phosphorylase expression in normal, hyperplastic and neoplastic prostates: correlation with tumour associated macrophages, infiltrating lymphocytes, and angiogenesis
Autor: Adrian L. Harris, K C Gatter, Efthimios Sivridis, M I Koukourakis, Alexandra Giatromanolaki, I Papadopoulos
Publikováno v: British Journal of Cancer
Thymidine phosphorylase is an angiogenic factor primarily expressed by cancer cells, stromal cells and tumour-associated macrophages in many human malignancies. These different types of thymidine phosphorylase-expressing cells, however, may have a di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9ebca1ba78f4c7d26f78c61069f549
https://ora.ox.ac.uk/objects/uuid:3545e920-0c5a-4df1-a93c-f08907bae63a
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10
Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis
Autor: Al Harris, K C Gatter, Alexandra Giatromanolaki, Efthimios Sivridis, M I Koukourakis, Georgios Bougioukas, Vassilios Didilis
Publikováno v: British Journal of Cancer
Lactate dehydrogenase-5 (LDH-5) catalyses the reversible transformation of pyruvate to lactate, having a principal position in the anaerobic cellular metabolism. Induction of LDH-5 occurs during hypoxia and LDH-5 transcription is directly regulated b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12caf7f7e03820133238ae9e5f99bca
https://ora.ox.ac.uk/objects/uuid:4a26dd7b-12c3-4968-b452-cdb01199014c
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