Výsledky vyhledávání - "K C, Raffaele"

Treatment of Alzheimer disease by continuous intravenous infusion of physostigmine

Autor: S, Asthana, K C, Raffaele, A, Berardi, N H, Greig, J V, Haxby, M B, Schapiro, T T, Soncrant

Publikováno v: Alzheimer disease and associated disorders. 9(4)

Physostigmine, a reversible and nonselective cholinesterase inhibitor, administered by steady-state, continuous intravenous infusion to carefully selected subjects with mild-moderate Alzheimer disease, produced significant but modest improvement in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4423494fe311fc13b7f6f7e92a5d704c
https://pubmed.ncbi.nlm.nih.gov/8749612

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Effects of long-term continuous infusion of the muscarinic cholinergic agonist arecoline on verbal memory in dementia of the Alzheimer type

Autor: K C, Raffaele, A, Berardi, S, Asthana, P, Morris, J V, Haxby, T T, Soncrant

Publikováno v: Psychopharmacology bulletin. 27(3)

Alzheimer's disease (AD) is accompanied by depletion of cholinergic markers in the central nervous system. In an attempt to improve cognitive function in AD, arecoline (a muscarinic cholinergic receptor agonist) was given to patients with probable or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a1f6285fb43c5a8d5fdcf027dbb2095d
https://pubmed.ncbi.nlm.nih.gov/1775605

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Neurotoxicology dose/response assessment for several cholinesterase inhibitors: use of uncertainty factors

Autor: K C, Raffaele, C, Rees

Publikováno v: Neurotoxicology. 11(2)

Dose/response assessment for non-carcinogenic endpoints typically uses the Acceptable Daily Intake (ADI) or Reference Dose (RfD) approach, in which a dose believed to cause no toxic effect is divided by a number of safety or uncertainty factors (e.g.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7cf438881247b611449593ac32e9d02
https://pubmed.ncbi.nlm.nih.gov/2234543

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Long-term effects of cholinergic agonists on memory

Autor: D S, Olton, K C, Raffaele

Publikováno v: NIDA research monograph. 97

Animal models provide important information about strategies that can be used to assess the effects of chronic exposure to drugs or other compounds. Furthermore, when used in conjunction with analyses designed to utilize the many advantages of animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f67690cfbc498e36f64a26a705dcd70
https://pubmed.ncbi.nlm.nih.gov/2247139

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Hippocampal and amygdaloid involvement in working memory for nonspatial stimuli

Autor: K C, Raffaele, D S, Olton

Publikováno v: Behavioral neuroscience. 102(3)

Hippocampal lesions in rats lead to an impairment of performance in spatial delayed conditional discriminations. The effect of such lesions on nonspatial tasks is controversial. In monkeys, both the hippocampus and the amygdala are involved in nonspa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc42d00eebcc590a3dbced07ee12f10d
https://pubmed.ncbi.nlm.nih.gov/3395446

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Behavioral consequences of intraperitoneal carbon monoxide administration in rats

Autor: S B, Fountain, K C, Raffaele, Z, Annau

Publikováno v: Toxicology and applied pharmacology. 83(3)

Blood carboxyhemoglobin (HbCO) was determined 15, 30, 45, 60, 90, and 120 min following ip injection of 2.5, 5, 10, 20, and 40 ml pure carbon monoxide (CO)/kg body wt in rats. These CO doses produced HbCO concentrations of 12, 24, 35, 45, and 60%, re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83e5d40ae90006b3d2b01403e59a77fd
https://pubmed.ncbi.nlm.nih.gov/3705074

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