Zobrazeno 1 - 10
of 39
pro vyhledávání: '"K Brazzell"'
Autor:
Billie M. York, D Barratt, Brenda W. Griffin, Young Han Park, R Barker, K Brazzell, Philip R. Mayer, Mark T. DuPriest
Publikováno v:
Xenobiotica. 22:543-550
1. Six potent aldose reductase inhibitors (ARI), three spirohydantoin (I to III) and three spirosuccinimide (IV to VI) compounds, showed similar IC50 activities in vitro for the inhibition of rat lens aldose reductase, but their ED50 values in diabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58fd10b785805f37214d9e30aa8da4b
https://doi.org/10.3109/00498259209053117
https://doi.org/10.3109/00498259209053117
Publikováno v:
Pharmaceutical Research. :469-473
To investigate the hypothesis that the pharmacokinetics of imirestat, an aldose reductase inhibitor, are influenced by saturable binding to tissues, three experiments were done. (1) The nature of the dose dependence was characterized in rats. Two gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e3ff5f8978ca6169e9850a513a91463
https://doi.org/10.1023/a:1015880011131
https://doi.org/10.1023/a:1015880011131
Publikováno v:
British Journal of Clinical Pharmacology. 32:221-227
1. The metabolism of the aldose reductase inhibitor, ALO1567, was studied in man. The major biotransformation pathway was aromatic hydroxylation followed by glucuronide conjugation. 2. Hydroxylation occurred at several positions on the fluorene ring.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcea464d672e9b4e866a303914abc1e1
https://doi.org/10.1111/j.1365-2125.1991.tb03885.x
https://doi.org/10.1111/j.1365-2125.1991.tb03885.x
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 565:255-264
A sensitive and selective gas chromatographic-electron-capture assay was developed for the determination of the aldose reductase inhibitor imirestat in lens and plasma. The method involves solid-phase extraction of drug and internal standard from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676e675840448973aae76edd2d0bf83f
https://doi.org/10.1016/0378-4347(91)80388-s
https://doi.org/10.1016/0378-4347(91)80388-s
Publikováno v:
Pharmaceutical Research. :112-118
The pharmacokinetics of imirestat were studied in healthy volunteers following single and multiple oral doses. After single doses of 20 to 50 mg, imirestat plasma concentrations declined with an apparent elimination half-life of 50 to 70 hr over the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4905751d03bdb1a69f9e8c0d3d118202
https://doi.org/10.1023/a:1015850911382
https://doi.org/10.1023/a:1015850911382
Publikováno v:
Pharmaceutical Research. :1198-1200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dafa20f90d3c4051af59b746529c2cf0
https://doi.org/10.1023/a:1015952930541
https://doi.org/10.1023/a:1015952930541
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Pharmaceutical research. 9(4)
To investigate the hypothesis that the pharmacokinetics of imirestat, an aldose reductase inhibitor, are influenced by saturable binding to tissues, three experiments were done. (1) The nature of the dose dependence was characterized in rats. Two gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a328cee46678522c508535edffb8dd12
https://pubmed.ncbi.nlm.nih.gov/1495891
https://pubmed.ncbi.nlm.nih.gov/1495891
Autor:
Joseph W. Massarella, Romulus K. Brazzell, George R. Aronoff, Michael E. Brier, Keiko Aogaichi, Mary Lou Mayer, Michael Barbalas, Rebecca S. Sloan
Publikováno v:
Journal of clinical pharmacology. 31(1)
To test the hypothesis that renal failure alters the disposition of cibenzoline in humans, an absolute bioavailability and elimination kinetic study was performed. We used the simultaneous administration of a stable isotope variant (SASIV). Eight hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093e693498d8740973bb0355739606b9
https://pubmed.ncbi.nlm.nih.gov/2045527
https://pubmed.ncbi.nlm.nih.gov/2045527
Publikováno v:
Pharmaceutical research. 7(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ebf2fde3f997f4b59347e904a4ab4cdc
https://pubmed.ncbi.nlm.nih.gov/2127314
https://pubmed.ncbi.nlm.nih.gov/2127314