Zobrazeno 1 - 10 of 282 pro vyhledávání: '"K Boland"'
1
Akademický článek
A covalent creatine kinase inhibitor ablates glioblastoma migration and sensitizes tumors to oxidative stress
Autor: Joshua L. Katz, Yuheng Geng, Leah K. Billingham, Nishanth S. Sadagopan, Susan L. DeLay, Jay Subbiah, Tzu-yi Chia, Graysen McManus, Chao Wei, Hanxiang Wang, Hanchen Lin, Caylee Silvers, Lauren K. Boland, Si Wang, Hanxiao Wan, David Hou, Gustavo Ignacio Vázquez-Cervantes, Tarlan Arjmandi, Zainab H. Shaikh, Peng Zhang, Atique U. Ahmed, Deanna M. Tiek, Catalina Lee-Chang, Edward T. Chouchani, Jason Miska
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Glioblastoma is a Grade 4 primary brain tumor defined by therapy resistance, diffuse infiltration, and near-uniform lethality. The underlying mechanisms are unknown, and no treatment has been curative. Using a recently developed creatine kin
Externí odkaz: https://doaj.org/article/dd7a023fe4514c80a5ab446bc7743f92
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2
Akademický článek
Efferocytosis of viable versus heat-inactivated MSC induces human monocytes to distinct immunosuppressive phenotypes
Autor: Michael V. Schrodt, Riley M. Behan-Bush, Jesse N. Liszewski, Madeleine E. Humpal-Pash, Lauren K. Boland, Sabrina M. Scroggins, Donna A. Santillan, James A. Ankrum
Publikováno v: Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Background Immunomodulation by mesenchymal stromal cells (MSCs) can occur through trophic factor mechanisms, however, intravenously infused MSCs are rapidly cleared from the body yet a potent immunotherapeutic response is still observed. Rec
Externí odkaz: https://doaj.org/article/f9fa036c76064ab2aa5c9e5b5e60b960
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3
Akademický článek
An Irish Multi-Centre Study of Behaviours, Attitudes and Barriers to Exercise in Inflammatory Bowel Disease, a Survey from the Patient’s Perspective
Autor: N. Gettigan Mc, K. Allen, C. Foley, S. Bennett, C. Lardner, T. Lukose, O. Kelly, A. O’Toole, K. Boland
Publikováno v: Gastrointestinal Disorders, Vol 4, Iss 4, Pp 312-323 (2022)
Background: Physical activity (PA) in inflammatory bowel disease (IBD) has many potential favourable outcomes including anti-inflammatory effects, improvement in quality of life and improvements in patient body composition. It is recognised that pati
Externí odkaz: https://doaj.org/article/9f4a2c276ea74bb1a1f6f559bbe16755
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5
Akademický článek
Adipose TBX1 regulates β-adrenergic sensitivity in subcutaneous adipose tissue and thermogenic capacity in vivo
Autor: Kathleen R. Markan, Lauren K. Boland, Abdul Qaadir King-McAlpin, Kristin E. Claflin, Michael P. Leaman, Morgan K. Kemerling, Madison M. Stonewall, Brad A. Amendt, James A. Ankrum, Matthew J. Potthoff
Publikováno v: Molecular Metabolism, Vol 36, Iss , Pp - (2020)
Objective: T-box 1 (TBX1) has been identified as a genetic marker of beige adipose tissue. TBX1 is a mesodermal development transcription factor essential for tissue patterning and cell fate determination. However, whether it plays a role in the proc
Externí odkaz: https://doaj.org/article/ce6dac942e13458db2784760abaedbf8
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6
Akademický článek
Aggregation of Human Mesenchymal Stromal Cells Eliminates Their Ability to Suppress Human T Cells
Autor: Anthony J. Burand, Lin Di, Lauren K. Boland, Devlin T. Boyt, Michael V. Schrodt, Donna A. Santillan, James A. Ankrum
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Mesenchymal stromal cells (MSCs) are administered locally to treat sites of inflammation. Local delivery is known to cause MSCs to aggregate into “spheroids,” which alters gene expression and phenotype. While adherent MSCs are highly efficient in
Externí odkaz: https://doaj.org/article/609c5705a33843329ad1f63a1442eed1
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9
Akademický článek
Nature vs. Nurture: Defining the Effects of Mesenchymal Stromal Cell Isolation and Culture Conditions on Resiliency to Palmitate Challenge
Autor: Lauren K. Boland, Anthony J. Burand, Devlin T. Boyt, Hannah Dobroski, Lin Di, Jesse N. Liszewski, Michael V. Schrodt, Maria K. Frazer, Donna A. Santillan, James A. Ankrum
Publikováno v: Frontiers in Immunology, Vol 10 (2019)
As MSC products move from early development to clinical translation, culture conditions shift from xeno- to xeno-free systems. However, the impact of isolation and culture-expansion methods on the long-term resiliency of MSCs within challenging trans
Externí odkaz: https://doaj.org/article/75f67edfb15a493890f48b8f4261923a
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