Zobrazeno 1 - 10
of 30
pro vyhledávání: '"K B Seamon"'
Autor:
J. Glickman, Michael Sheetz, K. B. Seamon, Thomas E. Kreis, J. Robbins, Richard D. Klausner, Jennifer Lippincott-Schwartz, Julie G. Donaldson
Publikováno v:
The Journal of Cell Biology
Brefeldin A (BFA) causes rapid redistribution of Golgi proteins into the ER, leaving no definable Golgi apparatus, and blocks transport of proteins into post-Golgi compartments in the cell. In this study we follow the disassembly of the Golgi apparat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271857900f9e4d12c064f260c020f9ca
https://doi.org/10.1083/jcb.112.4.567
https://doi.org/10.1083/jcb.112.4.567
Publikováno v:
The Journal of Immunology. 146:224-232
Neutrophils (PMN) treated with cAMP elevating agents were evaluated for their chemotactic responsiveness to FMLP and leukotriene B4 (LTB4). PGE1 and isoproterenol, increased PMN cyclic AMP production and inhibited chemotaxis to both FMLP and LTB4. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ead6668b4c60e77a01cdcddaffe1df80
https://doi.org/10.4049/jimmunol.146.1.224
https://doi.org/10.4049/jimmunol.146.1.224
Publikováno v:
Biochemical Journal. 272:151-158
Chemical and proteolytic digestion of intact erythrocyte glucose transporter as well as purified transporter protein has been used to localize the derivatization site for the photoaffinity agent 3-[125I]iodo-4-azido-phenethylamino-7-O-succinyldeacety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a00c2958c112ae0447f76bd0be3233d
https://doi.org/10.1042/bj2720151
https://doi.org/10.1042/bj2720151
Publikováno v:
Cellular and Molecular Neurobiology. 10:351-368
1. Forskolin, a naturally occurring diterpene that activates adenylate cyclase, HL706, a water-soluble derivative of forskolin (6β-[(piperidino)acetoxy]-7-desacetylforskolin) that is less potent than forskolin in activating adenylate cyclase, and 1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f5239475df23878eceb6fd463999cb
https://doi.org/10.1007/bf00711180
https://doi.org/10.1007/bf00711180
Publikováno v:
The Journal of Experimental Medicine
We have identified cell surface receptors for Act-2, a secreted protein expressed upon activation of T cells, B cells, and monocytes. Although 125I-Act-2 showed little, if any, specific binding to resting peripheral blood lymphocytes (PBL) receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698b3e3a68b9f131b2557e97abf90e93
https://doi.org/10.1084/jem.172.1.285
https://doi.org/10.1084/jem.172.1.285
Publikováno v:
Molecular pharmacology. 50(2)
Forskolin (Fsk) has been demonstrated to interact directly with the enzyme adenylyl cyclase (EC 4.6.1.1) in diverse tissues. However, the ability of Fsk to bind to and activate adenylyl cyclase varies depending on the tissue being studied. Different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d4596ff93065fd1f0059192ba3974bb
https://pubmed.ncbi.nlm.nih.gov/8700137
https://pubmed.ncbi.nlm.nih.gov/8700137
Publikováno v:
Journal of medicinal chemistry. 39(14)
Three series of analogs were regioselectively prepared from a protected forskolin precursor to afford 7-carbamoyl-7-desacetylforskolins (series 1), 6-carbamoyl-7-desacetylforskolins (series 2), and 6-carbamoylforskolins (series 3). The analogs were p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ffc4fba47f78ec3e065c52cd66e16554
https://pubmed.ncbi.nlm.nih.gov/8709105
https://pubmed.ncbi.nlm.nih.gov/8709105
Publikováno v:
Molecular pharmacology. 46(5)
To identify specific drug targets of the antimitotic drug estramustine, a photoaffinity analogue, 17-O-[[2-[3-(4-azido-3-[125I] iodophenyl)propionamido]ethyl]carbamyl]estradiol-3-N-bis(2- chloroethyl)carbamate, was synthesized and reacted in competit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3dd9cb473dc7c440a3eb12a9654a70c
https://pubmed.ncbi.nlm.nih.gov/7969073
https://pubmed.ncbi.nlm.nih.gov/7969073
Autor:
D I, Morris, L M, Greenberger, E P, Bruggemann, C, Cardarelli, M M, Gottesman, I, Pastan, K B, Seamon
Publikováno v:
Molecular pharmacology. 46(2)
An iodinated derivative of forskolin, 6-O-[[2-[3-(4-azido-3-[125I] iodophenyl)propionamido]ethyl]carbamyl]forskolin ([125I]6-AIPP-Fsk), photolabels the multidrug efflux pump P-glycoprotein in membranes prepared from the multidrug-resistant cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e48ddfac2af24fcd84e66773070b43d
https://pubmed.ncbi.nlm.nih.gov/7915819
https://pubmed.ncbi.nlm.nih.gov/7915819
Publikováno v:
Molecular pharmacology. 41(2)
7-(2-Aminoethyl)aminocarbonyl-7-desacetylforskolin (7-AEC-Fsk) and 6-(2-aminoethyl)aminocarbonylforskolin (6-AEC-Fsk) were synthesized and tested for their ability to activate adenylyl cyclase and inhibit the high affinity binding of [3H]forskolin to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d62edb13e9eaccbeb6b55531091f9662
https://pubmed.ncbi.nlm.nih.gov/1538712
https://pubmed.ncbi.nlm.nih.gov/1538712