Zobrazeno 1 - 10
of 13
pro vyhledávání: '"K B Frank"'
Publikováno v:
Journal of Biological Chemistry. 266:14232-14236
We examined the kinetic interaction of purified recombinant DNA-derived human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with R82150, a member of the tetrahydroimidazo[4,5,1-jk]-[1,4]-benzodiazepin-2(1H)-thione family of compounds (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea4b5dacf7a21cd471a0c46b54d06d44
https://doi.org/10.1016/s0021-9258(18)98672-2
https://doi.org/10.1016/s0021-9258(18)98672-2
Publikováno v:
The Journal of biological chemistry. 266(34)
Metal chelate affinity chromatography has been used to follow reconstitution of the 66- and 51-kDa human immunodeficiency (HIV)-1 and HIV-2 reverse transcriptase (RT) subunits into heterodimer, as well as chimeric enzymes comprised of heterologous su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a348350c31bfeda8a8b0349fed3e7a9
https://pubmed.ncbi.nlm.nih.gov/1720776
https://pubmed.ncbi.nlm.nih.gov/1720776
Publikováno v:
The Journal of biological chemistry. 266(22)
We examined the kinetic interaction of purified recombinant DNA-derived human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with R82150, a member of the tetrahydroimidazo[4,5,1-jk]-[1,4]-benzodiazepin-2(1H)-thione family of compounds (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::90be5a2fdb23ad3eee8a1eb8a1d9b025
https://pubmed.ncbi.nlm.nih.gov/1713579
https://pubmed.ncbi.nlm.nih.gov/1713579
Publikováno v:
Journal of Biological Chemistry. 259:1566-1569
The triphosphate of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) competitively inhibits incorporation of dGTP into DNA catalyzed by DNA polymerases specified by both type 1 and type 2 herpes simplex virus. K1 values were estimated to be 33 nM for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac58bdc5894e3a1ee40fdbf333060cec
https://doi.org/10.1016/s0021-9258(17)43446-6
https://doi.org/10.1016/s0021-9258(17)43446-6
Autor:
K B Frank, Yung-Chi Cheng
Publikováno v:
Journal of Biological Chemistry. 261:1510-1513
Purine ribonucleoside monophosphates were found to inhibit chain elongation catalyzed by herpes simplex virus (HSV) DNA polymerase when DNA template-primer concentrations were rate-limiting. Inhibition was fully competitive with DNA template-primer d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b31e938eed339dcf97de299446f9010
https://doi.org/10.1016/s0021-9258(17)35968-9
https://doi.org/10.1016/s0021-9258(17)35968-9
Publikováno v:
Antimicrobial Agents and Chemotherapy. 31:1369-1374
Inhibition of visna virus replication in vitro by several compounds previously reported to inhibit replication of human immunodeficiency virus (HIV) was examined. Ribavirin concentrations as high as 1 mM reduced virus production by less than 50% rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6f9dcb8b7bdcdbc9896e01f1f7ae26
https://doi.org/10.1128/aac.31.9.1369
https://doi.org/10.1128/aac.31.9.1369
Publikováno v:
IUPHAR 9th International Congress of Pharmacology London 1984 ISBN: 9780333371343
Viruses as a whole are important pathogens. They have also been found to have a close association with certain human malignancies. Five types of herpesviruses were identified to be the causative agents in human diseases. They are herpes simplex virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f48edc3db63fce082fbf031602341b1
https://doi.org/10.1007/978-1-349-17613-7_34
https://doi.org/10.1007/978-1-349-17613-7_34
Publikováno v:
The Journal of biological chemistry. 259(3)
The triphosphate of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) competitively inhibits incorporation of dGTP into DNA catalyzed by DNA polymerases specified by both type 1 and type 2 herpes simplex virus. K1 values were estimated to be 33 nM for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::73c87bd1aaffb062bbf57eb53144dded
https://pubmed.ncbi.nlm.nih.gov/6319402
https://pubmed.ncbi.nlm.nih.gov/6319402
Autor:
K. Nakayama, Jwo-Farn Chiou, Ginger E. Dutschman, Susan P. Grill, Kenneth F. Bastow, K B Frank, Yung-Chi Cheng
Publikováno v:
Antimicrobial agents and chemotherapy. 26(3)
We examined the effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) on viral DNA, RNA, protein, and enzyme synthesis in HeLa cells infected with herpes simplex virus type 1 and type 2. DHPG inhibited virus DNA synthesis in a dose-dependent fash
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7d5605c29e206940bfbf09f93ee931
https://pubmed.ncbi.nlm.nih.gov/6095751
https://pubmed.ncbi.nlm.nih.gov/6095751
Autor:
K B, Frank, Y C, Cheng
Publikováno v:
The Journal of biological chemistry. 261(4)
Purine ribonucleoside monophosphates were found to inhibit chain elongation catalyzed by herpes simplex virus (HSV) DNA polymerase when DNA template-primer concentrations were rate-limiting. Inhibition was fully competitive with DNA template-primer d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f8f228946571238630035d91fd9810a
https://pubmed.ncbi.nlm.nih.gov/3003073
https://pubmed.ncbi.nlm.nih.gov/3003073