Zobrazeno 1 - 10
of 24
pro vyhledávání: '"K B Bacon"'
Autor:
Gail M. Gauvreau, Linda Hui, JM FitzGerald, S Boehme, Abbey Schlatman, J Kum, Richard M. Watson, Paul M. O'Byrne, L.-P. Boulet, Caitlin Obminski, K B Bacon, H Villineuve, Tara Scime, T W Ly
Publikováno v:
Clinical & Experimental Allergy. 48:445-451
Background CCR3 is the cognate receptor for major human eosinophil chemoattractants from the eotaxin family of proteins that are elevated in asthma and correlate with disease severity. Objective This proof-of-mechanism study examined the effect of AX
Autor:
Akira Ishii, K. B. Bacon, Motoyasu Iikura, Chitose Yoshimura-Uchiyama, Hiroyuki Nagase, Koichi Hirai, Keiichiro Yamamoto, Munehiro Yamaguchi, Michitaka Shichijo, Koji Matsushima
Publikováno v:
Clinical Experimental Allergy. 34:1283-1290
Summary Background Both prostaglandin (PG) D receptor (DP) and CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells)/DP2 are high-affinity receptors for PGD2. Previous studies have demonstrated that PGD2 enhances releasability a
Publikováno v:
The Journal of Immunology. 163:1628-1635
Molecular analyses of the chemokine fractalkine and its receptor CX3C-R1 in the rat brain have revealed a striking polarization: fractalkine is expressed constitutively in neurons and is up-regulated by TNF-α and IL-1β in astrocytes. Expression of
Publikováno v:
The Journal of Experimental Medicine
The chemokine RANTES is a chemoattractant and activating factor for T lymphocytes. Investigation of the signal transduction mechanisms induced by RANTES in T cells revealed tyrosine phosphorylation of multiple protein species with prominent bands at
Autor:
T Hara, K B Bacon, L C Cho, A Yoshimura, Y Morikawa, N G Copeland, D J Gilbert, N A Jenkins, T J Schall, A Miyajima
Publikováno v:
The Journal of Immunology. 155:5352-5358
Chemokines play an important role in immune and inflammatory responses by inducing migration and adhesion of leukocytes. We have isolated a novel chemokine cDNA, designated CCF18, from a cDNA library of an IL-3-dependent murine pro-B cell line, Ba/F3
Autor:
J Kennedy, G S Kelner, S Kleyensteuber, T J Schall, M C Weiss, H Yssel, P V Schneider, B G Cocks, K B Bacon, A Zlotnik
Publikováno v:
The Journal of Immunology. 155:203-209
We describe the isolation of a cDNA that encodes human lymphotactin (Ltn), a new class of lymphocyte-specific chemokine. Human Ltn shows similarity to some members of the C-C chemokine family but has lost the first and third cysteine residues that ar
Autor:
K B Bacon, L Flores-Romo, P F Life, D D Taub, B A Premack, S J Arkinstall, T N Wells, T J Schall, C A Power
Publikováno v:
The Journal of Immunology. 154:3654-3666
We have characterized the IL-8-induced signal transduction processes in T lymphocytes. A basal level of IL-8 receptor expression was shown on mixed PBL, as identified by using phycoerythrin (PE)-coupled IL-8, and this expression was increased followi
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(3)
Eotaxin is a potent eosinophil chemoattractant that plays an important role in regulating eosinophil tissue levels both in healthy individuals and in diseases associated with significant eosinophil infiltrates, such as the allergic inflammation obser
Autor:
K, Franz-Bacon, D J, Dairaghi, S A, Boehme, S K, Sullivan, T J, Schall, P J, Conlon, N, Taylor, K B, Bacon
Publikováno v:
Blood. 93(10)
Eotaxin has been characterized as a chemokine involved in eosinophil activation; however, mRNA for this C-C chemokine has been shown to be constitutively expressed in thymus. Immunohistochemical analysis showed a punctate distribution pattern, with e
Publikováno v:
Journal of clinical immunology. 18(3)
We have isolated a novel human C-C chemokine, MIP-1 delta from a human fetal spleen cDNA library. The human MIP-1 delta cDNA has an unusually long 400-bp 5-prime untranslated region and a predicted 113-amino acid protein of 10 kDa. The coding sequenc