Výsledky vyhledávání - "K B, Pryzwansky"

Cyclic guanosine monophosphate-dependent protein kinase is targeted to intermediate filaments and phosphorylates vimentin in A23187-stimulated human neutrophils

Autor: K B, Pryzwansky, T A, Wyatt, T M, Lincoln

Publikováno v: Blood. 85(1)

The effects of the calcium ionophore, A23187, on human neutrophil activation were studied in relation to the signaling mechanism of cyclic guanosine monophosphate (cGMP)-dependent protein kinase (G-kinase). Immunocytochemistry demonstrated that G-kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::081fca23e502bdca269ac2292672d16a
https://pubmed.ncbi.nlm.nih.gov/7803796

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Regulation of sarcoplasmic reticulum protein phosphorylation by localized cyclic GMP-dependent protein kinase in vascular smooth muscle cells

Autor: T L, Cornwell, K B, Pryzwansky, T A, Wyatt, T M, Lincoln

Publikováno v: Molecular pharmacology. 40(6)

The role of cGMP-dependent protein kinase in the regulation of intracellular Ca2+ levels in vascular smooth muscle cells was examined by studying the effects of cGMP on the phosphorylation of the Ca(2+)-ATPase regulatory protein phospholamban. Cultur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64e29fcf233c00a3e241441ba436acfb
https://pubmed.ncbi.nlm.nih.gov/1836834

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Vimentin is transiently co-localized with and phosphorylated by cyclic GMP-dependent protein kinase in formyl-peptide-stimulated neutrophils

Autor: T A, Wyatt, T M, Lincoln, K B, Pryzwansky

Publikováno v: The Journal of biological chemistry. 266(31)

The effects of cGMP-dependent protein kinase (G-kinase), a major cellular receptor of cGMP, were investigated in activated human neutrophils. Immunocytochemistry demonstrated that G-kinase translocated from a diffuse localization in the cytoplasm to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef8d5e3e60e6ce1a0fa6bf60720fced0
https://pubmed.ncbi.nlm.nih.gov/1657955

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KT5823 activates human neutrophils and fails to inhibit cGMP-dependent protein kinase phosphorylation of vimentin

Autor: T A, Wyatt, K B, Pryzwansky, T M, Lincoln

Publikováno v: Research communications in chemical pathology and pharmacology. 74(1)

The effectiveness of the cGMP-dependent protein kinase inhibitor, KT5823, was investigated in human neutrophils. KT5823 did not inhibit the cGMP-dependent protein kinase mediated in vitro, or in situ phosphorylation of vimentin, a known substrate for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::792cb6c633c59becd861a6fdc832c93f
https://pubmed.ncbi.nlm.nih.gov/1666198

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Phorbol ester induces transient focal concentrations of functional, newly expressed CR3 in neutrophils at sites of specific granule exocytosis

Autor: K B, Pryzwansky, T, Wyatt, W, Reed, G D, Ross

Publikováno v: European journal of cell biology. 54(1)

Treatment of neutrophils with phorbol myristate acetate (PMA) increases surface expression of CR3 (iC3b-receptor; CD11b/CD18). This up-regulation was examined in whole-mount preparations of adherent neutrophils by stereo high voltage immunoelectron m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::744bfe7acb0475bcf62bb2ab201efccc
https://pubmed.ncbi.nlm.nih.gov/2032553

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Compartmentalization of cyclic GMP-dependent protein kinase in formyl-peptide stimulated neutrophils

Autor: K B, Pryzwansky, T A, Wyatt, H, Nichols, T M, Lincoln

Publikováno v: Blood. 76(3)

The presence and physiologic role of cyclic GMP-dependent protein kinase (G-kinase) in human neutrophils was investigated by Western blot analysis and immunocytochemistry. Small quantities of G-kinase were found in the cytoskeletal-enriched fraction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2bdf7fc716cd760efbc77b02d3557f8
https://pubmed.ncbi.nlm.nih.gov/2165830

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Sequential events in the pathogenesis of streptococcal cell wall-induced arthritis and their modulation by bis(5-amidino-2-benzimidazolyl)methane (BABIM)

Autor: J D, Geratz, R R, Tidwell, J H, Schwab, S K, Anderle, K B, Pryzwansky

Publikováno v: The American journal of pathology. 136(4)

This report builds on the authors' earlier discovery of bis(5-amidino-2-benzimidazolyl)methane (BABIM) as a strong suppressive agent for streptococcal cell wall fragment-induced arthritis in the Lewis rat. As a synthetic inhibitor of trypsinlike prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::27e9e2d2b7ff82c7762fc6bafae8ea2d
https://pubmed.ncbi.nlm.nih.gov/2327474

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Human neutrophil dysfunction with giant granules and defective activation of the respiratory burst

Autor: P E, Newburger, J M, Robinson, K B, Pryzwansky, P M, Rosoff, J S, Greenberger, A I, Tauber

Publikováno v: Blood. 61:1247-1257

We describe a patient whose peripheral blood neutrophils and bone marrow precursors (beyond promyelocytes) contained multiple large azurophilic granules. There were also giant granules in eosinophils, basophils, melanocytes, renal tubules, thyroid, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bfcf73dbd9f1ce9867c1a94bb66c26
https://doi.org/10.1182/blood.v61.6.1247.bloodjournal6161247

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