Zobrazeno 1 - 9
of 9
pro vyhledávání: '"K B, Gershkovich"'
Publikováno v:
Bioorganicheskaia khimiia. 40(5)
By variation of incubation time of streptokinase (SK) with activated polyethylene glycol (M 2 and 5 kDa, PEG2 and PEG5) it was obtained covalent SK-PEG2 and SK-PEG5 conjugates with different modification degrees of amino groups of protein and their p
Publikováno v:
Bioorganicheskaia khimiia. 39(4)
Thrombolytic therapy by high doses of streptokinase (SK) that are stipulated by its rapid clearance is accompanied by side effects. In this work for the purpose of lifetime prolongation in bloodstream and decrease in side effects SK was included in m
Publikováno v:
Izvestiia Akademii nauk SSSR. Seriia biologicheskaia. (4)
Autor:
M A, Rozenfel'd, K B, Gershkovich
Publikováno v:
Molekuliarnaia biologiia. 22(4)
In this study we have produced for the first time a native fibrinogen copolymer with a fragment of fibrin E. and the molecular mechanism of its formation was studied by different physicochemical methods. Based on the data of angular dependency of the
Publikováno v:
Izvestiia Akademii nauk SSSR. Seriia biologicheskaia. (1)
Autor:
K B, Gershkovich, M A, Rozenfel'd
Publikováno v:
Molekuliarnaia biologiia. 23(2)
The methods of viscosimetry, the Rayleigh light-scattering and analytical ultracentrifugation were applied to study the physicochemical mechanism of the effect of fragment D on the structure of fibrin equilibrium oligomers. Using the values of intrin
Autor:
M A, Rozenfel'd, K B, Gershkovich
Publikováno v:
Izvestiia Akademii nauk SSSR. Seriia biologicheskaia. (2)
Generalized concepts of some structural peculiarities of fibrinogen, its transformation into fibrin and assembly have been considered on the basis of author's and published data. The role of local conformational changes in different areas of fibrinog
Publikováno v:
Molekuliarnaia biologiia. 22(1)
The morphology of equilibrium of soluble fibrin oligomers at different stages of assembly was studied. Results of Rauleigh's light scattering, analytical ultracentrifugation and viscosimetry show that fibrin-polymers throughout the entire homology ra
Publikováno v:
Molekuliarnaia biologiia. 20(4)
Three-dimensional organization of intermediate soluble forms of fibrin-polymers--a product of fibrin-monomer assembly--in the presence of non-denaturating urea concentrations has been studied. Hydrodynamic parameters of fibrinogen and fibrin-polymers