Zobrazeno 1 - 10
of 523
pro vyhledávání: '"K Albanese"'
Autor:
Gregory A. Ross, Chao Lu, Guido Scarabelli, Steven K. Albanese, Evelyne Houang, Robert Abel, Edward D. Harder, Lingle Wang
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Computational techniques can speed up the identification of hits and accelerate the development of candidate molecules for drug discovery. Among techniques for predicting relative binding affinities, the most consistently accurate is free en
Externí odkaz:
https://doaj.org/article/79d1308e170847339a53931494a3e639
Autor:
Gerard Minuesa, Steven K. Albanese, Wei Xie, Yaniv Kazansky, Daniel Worroll, Arthur Chow, Alexandra Schurer, Sun-Mi Park, Christina Z. Rotsides, James Taggart, Andrea Rizzi, Levi N. Naden, Timothy Chou, Saroj Gourkanti, Daniel Cappel, Maria C. Passarelli, Lauren Fairchild, Carolina Adura, J. Fraser Glickman, Jessica Schulman, Christopher Famulare, Minal Patel, Joseph K. Eibl, Gregory M. Ross, Shibani Bhattacharya, Derek S. Tan, Christina S. Leslie, Thijs Beuming, Dinshaw J. Patel, Yehuda Goldgur, John D. Chodera, Michael G. Kharas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.
Externí odkaz:
https://doaj.org/article/0841d30974ee49439a137cb5c41e499b
Autor:
Paulina M. Wojnarowicz, Raquel Lima e Silva, Masayuki Ohnaka, Sang Bae Lee, Yvette Chin, Anita Kulukian, Sung-Hee Chang, Bina Desai, Marta Garcia Escolano, Riddhi Shah, Marta Garcia-Cao, Sijia Xu, Rashmi Kadam, Yehuda Goldgur, Meredith A. Miller, Ouathek Ouerfelli, Guangli Yang, Tsutomu Arakawa, Steven K. Albanese, William A. Garland, Glenn Stoller, Jaideep Chaudhary, Larry Norton, Rajesh Kumar Soni, John Philip, Ronald C. Hendrickson, Antonio Iavarone, Andrew J. Dannenberg, John D. Chodera, Nikola Pavletich, Anna Lasorella, Peter A. Campochiaro, Robert Benezra
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 62-75.e7 (2019)
Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states. Id proteins are primarily expressed during development to
Externí odkaz:
https://doaj.org/article/95d35ea0d3dd4fce8521d6c45f7d1b30
Autor:
Emily F Ruff, Joseph M Muretta, Andrew R Thompson, Eric W Lake, Soreen Cyphers, Steven K Albanese, Sonya M Hanson, Julie M Behr, David D Thomas, John D Chodera, Nicholas M Levinson
Publikováno v:
eLife, Vol 7 (2018)
Many eukaryotic protein kinases are activated by phosphorylation on a specific conserved residue in the regulatory activation loop, a post-translational modification thought to stabilize the active DFG-In state of the catalytic domain. Here we use a
Externí odkaz:
https://doaj.org/article/f6eb943b1d3d40128485f13e5dbe282f
Autor:
Jesse M Hansen, Joshua J McElwee, Eric M. Lynch, Kevin D Kreutter, Gydo C. P. van Zundert, Michael A. DiMattia, Joel Quispe, Andreas Verras, Steven K. Albanese, Neelu Kaila, Justin M. Kollman, Angela V. Toms, Madison Arza Kennedy, Kenneth W. Borrelli
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance An effective immune response depends on the proliferation of T cells, a process that requires the enzyme CTP synthase 1 (CTPS1). Individuals lacking CTPS1 due to a rare genetic disorder exhibit severe immunodeficiencies but lack other ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e970023a4f204df8bc5bb1e49ba04c6
https://doi.org/10.1073/pnas.2107968118
https://doi.org/10.1073/pnas.2107968118
Autor:
Dinshaw J. Patel, Christina Z. Rotsides, Shibani Bhattacharya, Derek S. Tan, Sun Mi Park, Steven K. Albanese, Fraser Glickman, Alexandra Schurer, Minal Patel, Yaniv Kazansky, Daniel Worroll, Gerard Minuesa, Michael G. Kharas, Yehuda Goldgur, John D. Chodera, Arthur Chow, Gregory M. Ross, Lauren Fairchild, Thijs Beuming, Carolina Adura, James Taggart, Saroj Gourkanti, Wei Xie, Jessica Schulman, Maria C. Passarelli, Levi N. Naden, Andrea Rizzi, Timothy Chou, Joseph K. Eibl, Christopher Famulare, Daniel Cappel, Christina S. Leslie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
The MUSASHI (MSI) family of RNA binding proteins (MSI1 and MSI2) contribute to a wide spectrum of cancers including acute myeloid leukemia. We find that the small molecule Ro 08–2750 (Ro) binds directly and selectively to MSI2 and competes for its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c97023cb0a4bf35b9e859b49ae0ce48
http://link.springer.com/article/10.1038/s41467-019-10523-3
http://link.springer.com/article/10.1038/s41467-019-10523-3
Autor:
Agatha Lyczek, Aziz M Rangwala, YiTing Paung, Jessica Tom, John D. Chodera, Markus A. Seeliger, Matthew B. Robers, Stefan Knapp, Jiaye Guo, Hannah Philipose, Benedict-Tilman Berger, Steven K. Albanese
Protein kinase inhibitors are potent anti-cancer therapeutics (1). For example, the Bcr-Abl kinase inhibitor imatinib decreases mortality for Chronic Myeloid Leukemia (CML) by 80% (2, 3), but 22-41% of patients acquire resistance to imatinib (4). Abo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd69ca677774e14b1401b47658688b79
https://doi.org/10.1101/2021.06.28.449968
https://doi.org/10.1101/2021.06.28.449968
Publikováno v:
Journal of chemical information and modeling
Alchemical free-energy calculations are now widely used to drive or maintain potency in small-molecule lead optimization with a roughly 1 kcal/mol accuracy. Despite this, the potential to use free-energy calculations to drive optimization of compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4693c1a64d3ed19a7c1e8499e96b07
https://pubmed.ncbi.nlm.nih.gov/33119284
https://pubmed.ncbi.nlm.nih.gov/33119284
Alchemical free energy calculations are now widely used to drive or maintain potency in small molecule lead optimization with a roughly 1 kcal/mol accuracy. Despite this, the potential to use free energy calculations to drive optimization of compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eea18ad64c7ff7c4f15a3260adbe9320
https://doi.org/10.1101/2020.07.02.185132
https://doi.org/10.1101/2020.07.02.185132
Autor:
Justin Taylor, Fabian Correa, Craig B. Thompson, Bo Wang, Gregory A. Petsko, Zenon D. Konteatis, Noushin Farnoud, Maria E. Arcila, Bin Wu, Ariën S. Rustenburg, Sung Choe, Mikhail Roshal, Naofumi Takemoto, Ross L. Levine, Vidushi Durani, Andrew M. Intlekofer, Steven K. Albanese, Hui Liu, Christopher Famulare, Eytan M. Stein, Scott A. Biller, Elli Papaemmanuil, Minal Patel, Justin R. Cross, Abbas Nazir, Martin S. Tallman, Alan H. Shih, John D. Chodera
Publikováno v:
Nature
Somatic mutations in the isocitrate dehydrogenase 2 gene (IDH2) contribute to the pathogenesis of acute myeloid leukaemia (AML) through the production of the oncometabolite 2-hydroxyglutarate (2HG)1–8. Enasidenib (AG-221) is an allosteric inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5755791ce937d711d3a623bbe5c5e1c5
https://doi.org/10.1038/s41586-018-0251-7
https://doi.org/10.1038/s41586-018-0251-7