Zobrazeno 1 - 10 of 33 pro vyhledávání: '"K A, Siminovitch"'
1
Glucagon-like peptide-1 receptor signalling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T cells
Autor: K. A. Siminovitch, Daniel J. Drucker, Jayne S. Danska, I. Hadjiyanni
Publikováno v: Diabetologia. 53:730-740
Glucagon-like peptide-1 receptor (GLP-1R) agonists improve glucose control in animals and humans with type 1 diabetes. However, there is little information on the role of the GLP-1R in the immune system. We studied the role of the GLP-1R in immune fu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac53cdcad566a6f77682a2a3c3440ace
https://doi.org/10.1007/s00125-009-1643-x
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2
The immunogenetics of primary biliary cirrhosis: A comprehensive review
Autor: G J, Webb, K A, Siminovitch, G M, Hirschfield
Publikováno v: Journal of Autoimmunity
Primary biliary cirrhosis (PBC), a classic autoimmune liver disease, is characterised by a progressive T cell predominant lymphocytic cholangitis, and a serologic pattern of reactivity in the form of specific anti-mitochondrial antibodies (AMA). CD4+
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a9d19266f4528f1e7d4c1a43e40d22d
https://pubmed.ncbi.nlm.nih.gov/26250073
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3
Asthma on Tristan da Cunha: looking for the genetic link. The University of Toronto Genetics of Asthma Research Group
Autor: Arthur S. Slutsky, P R Sandell, Noe Zamel, P. A. McClean, K A Siminovitch
Publikováno v: American Journal of Respiratory and Critical Care Medicine. 153:1902-1906
Although asthma has a significant heritable component, the mode of inheritance remains controversial because of the complexity of the disease and the influence of environmental factors. Isolated, inbred populations serve to reduce variability, thus i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc199720acfcff5f9a171ce69d95b09
https://doi.org/10.1164/ajrccm.153.6.8665053
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4
Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native population
Autor: Y Lu, Nina A. Daha, Jeanine J. Houwing-Duistermaat, Irene Smolik, Hani El-Gabalawy, K A Siminovitch, Ye Sun, David B. Robinson, Donna Hart, Charles N. Bernstein, Kiem Oen, Brenda Elias
Publikováno v: Genes and Immunity, 12(7), 568-574
Most of the genetic risk for rheumatoid arthritis (RA) is conferred by 'shared epitope' (SE), encoding alleles of HLA-DRB1. Specific North American Native (NAN) populations have RA prevalence rates of 2-5%, representing some of the highest rates esti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815c070c7e80f3362dab8dfd2f3682eb
https://pubmed.ncbi.nlm.nih.gov/21614018
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5
Genetics of inflammatory bowel disease: where are we?
Autor: M. S. Silverberg, A.-K. Somani, K. A. Siminovitch
Publikováno v: Trends in Inflammatory Bowel Disease Therapy 1999 ISBN: 9789401057691
Recent advances in recombinant DNA technology have rendered feasible the application of a positional cloning strategy to the identification of inflammatory bowel disease (IBD) susceptibility genes. In this context many groups have now performed genom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86a7f6e1ee31a6d17d469e94d3360666
https://doi.org/10.1007/978-94-011-4002-7_1
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6
Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-gamma-triggered JAK2 activation
Autor: J, Blanchette, N, Racette, R, Faure, K A, Siminovitch, M, Olivier
Publikováno v: European journal of immunology. 29(11)
Leishmania-induced macrophage (Mphi) dysfunctions have been correlated with altered signaling events. Recent findings from our laboratory suggest that modulation of host protein tyrosine phosphatase (PTP) following Leishmania infection could lead to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14e6edb8e54fce0366491c6d9e679bd0
https://pubmed.ncbi.nlm.nih.gov/10556830
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8
Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection
Autor: J, Zhang, A K, Somani, D, Yuen, Y, Yang, P E, Love, K A, Siminovitch
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(6)
The selection events shaping T cell development in the thymus represent the outcome of TCR-driven intracellular signaling cascades evoked by Ag receptor interaction with cognate ligand. In view of data indicating TCR-evoked thymocyte proliferation to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a80d2b105ae7471a267b7712fd8da874
https://pubmed.ncbi.nlm.nih.gov/10477564
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9
Molecular intensive care medicine
Autor: Jesús Villar, K. A. Siminovitch
Publikováno v: Intensive care medicine. 25(7)
The development of methods for the analysis of gene structure and function, referred to as recombinant DNA (deoxyribonucleic acid) technology, has created unprecedented opportunities for significantly improving the prevention or treatment of human di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d82c85b91713cb3a47de1a7625c19b
https://pubmed.ncbi.nlm.nih.gov/10470567
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