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Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam

Autor: T. A. Alsenani, S. L. Viviani, V. Kumar, M. A. Taracila, C. R. Bethel, M. D. Barnes, K. M. Papp-Wallace, R. K. Shields, M. H. Nguyen, C. J. Clancy, R. A. Bonomo, F. van den Akker

Publikováno v: Antimicrob Agents Chemother

Klebsiella pneumoniae carbapenemases (KPC-2 and KPC-3) present a global clinical threat, as these β-lactamases confer resistance to carbapenems and oxyimino-cephalosporins. Recent clinically identified KPC variants with substitutions at Ambler posit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917a87e764dab5280e41c9af56c94051
https://doi.org/10.1128/aac.02414-21

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Sensitivity of the Preclinical Alzheimer’s Cognitive Composite (PACC), PACC5, and Repeatable Battery for Neuropsychological Status (RBANS) to Amyloid Status in Preclinical Alzheimer’s Disease -Atabecestat Phase 2b/3 EARLY Clinical Trial

Autor: K V, Papp, H, Rofael, A E, Veroff, M C, Donohue, S, Wang, C, Randolph, E, Grober, H R, Brashear, G, Novak, K, Ernstrom, R, Raman, P S, Aisen, R, Sperling, G, Romano, D, Henley

Publikováno v: The Journal Of Prevention of Alzheimer's Disease.

Cognitive composites commonly serve as primary outcomes in Alzheimer's disease (AD) secondary prevention trials.To evaluate the association between amyloid (Aβ) burden level (+/-) and performance on three separate composite endpoints: Preclinical Al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa58a00ebda7e0191392303cb83bb88
https://doi.org/10.14283/jpad.2022.17

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Granulocyte-macrophage colony-stimulating factor (GM-CSF) as a therapeutic target in psoriasis: randomized, controlled investigation using namilumab, a specific human anti-GM-CSF monoclonal antibody

Autor: K A, Papp, M, Gooderham, R, Jenkins, R, Vender, J C, Szepietowski, T, Wagner, B, Hunt, B, Souberbielle

Publikováno v: The British journal of dermatology. 180(6)

The relevance of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the management of psoriasis has not been studied previously. GM-CSF is important in the initiation and maintenance of chronic inflammatory processes.To investigate the clin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca29dc01fcd349724ff713cb90a08da2
https://pubmed.ncbi.nlm.nih.gov/31157451

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Tumor Necrosis Factor Inhibition

Autor: Mathew N Nicholas, K. A. Papp

Publikováno v: Biologic and Systemic Agents in Dermatology ISBN: 9783319668833

TNF antagonists revolutionized the treatment of several high-needs inflammatory conditions including plaque psoriasis and hidradenitis suppurativa. After an initial, sputtering start in MS, septic shock, and congestive heart failure, clinical trials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8450bdbc4543e689297c6a419522153
https://doi.org/10.1007/978-3-319-66884-0_13

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Randomized Placebo-Controlled Trial of Metronidazole 1 % Cream with Sunscreen SPF 15 in Treatment of Rosacea

Autor: J. K. L. Tan, C. Girard, A. Krol, H. E. Murray, K. A. Papp, Y. Poulin, D. A. Chin, D. Jeandupeux

Publikováno v: Journal of Cutaneous Medicine and Surgery. 6:529-534

Background: Rosacea is a photoaggravated dermatosis responsive to treatment with topical and oral antibiotics. A formulation combining metronidazole 1% cream with sunscreen SPF 15 was developed for the treatment of rosacea. Objective: The objective o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::973fad1e8d2f6ab0597fbc3c0146a6ff
https://doi.org/10.1177/120347540200600602

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Long-term safety of ustekinumab in patients with moderate-to-severe psoriasis: final results from 5 years of follow-up

Autor: K A, Papp, C E M, Griffiths, K, Gordon, M, Lebwohl, P O, Szapary, Y, Wasfi, D, Chan, M-C, Hsu, V, Ho, P D, Ghislain, B, Strober, K, Reich

Publikováno v: The British journal of dermatology. 168(4)

Long-term safety evaluations of biologics are needed to inform patient management decisions.To evaluate the safety of ustekinumab in patients with moderate-to-severe psoriasis treated for up to 5 years.Safety data were pooled from four studies of ust

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83ecd347fcf1c8efe3eb355ac38bc760
https://pubmed.ncbi.nlm.nih.gov/23301632

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