Výsledky vyhledávání

Severe combined immunodeficient (SCID) mice: a model for investigating human thyroid autoantibody synthesis

Autor: K A Leader, P. Yates, D. I. W. Phillips, L. M. Macht, B. Rees Smith, N. Fukuma, D. Sarsero, Sandra M. McLachlan, Christopher J. Elson, C. A. S. Pegg

Publikováno v: Clinical and Experimental Immunology. 84:34-42

SUMMARY We have studied the ability of lymphocytes from the blood, thyroid and lymph nodes of patients with autoimmune thyroid disease (AITD) to produce auloantibodies to thyroglobulin (Tg) and/or thyroid peroxidasc (TPO) in SCID mice. Human IgG clas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8b40a9bd6a1686d49aa402af710db3
https://doi.org/10.1111/j.1365-2249.1991.tb08120.x

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Modulation of human DNA topoisomerase IIalpha function by interaction with 14-3-3epsilon

Autor: E U, Kurz, K B, Leader, D J, Kroll, M, Clark, F, Gieseler

Publikováno v: The Journal of biological chemistry. 275(18)

Human DNA topoisomerase IIalpha (topo II), a ubiquitous nuclear enzyme, is essential for normal and neoplastic cellular proliferation and survival. Several common anticancer drugs exert their cytotoxic effects through interaction with topo II. In exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5ae285c8ccfa3b7dc908a66f68dd236
https://pubmed.ncbi.nlm.nih.gov/10788521

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Serial changes in the galactosylation of autoantibodies and serum IgG in autoimmune haemolytic anaemia

Autor: Robert N. Barker, K A Leader, Christopher J. Elson

Publikováno v: Autoimmunity. 31(2)

A number of systemic autoimmune diseases are associated with increased levels of the agalactosyl (G0) IgG isoforms that lack a terminal galactose from the C(H)2 domain oligosaccharide. The aims were to determine whether there are also persistently hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2301862720200a1f999afe4a34beb93
https://pubmed.ncbi.nlm.nih.gov/10680748

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Galactosylation of serum IgG and autoantibodies in murine models of autoimmune haemolytic anaemia

Autor: K A Leader, Robert N. Barker, Christopher J. Elson, R D Young

SUMMARY A number of systemic autoimmune diseases are associated with increased levels of the agalactosyl (G0) IgG isoforms that lack a terminal galactose from the CH2 domain oligosaccharide. The current aim was to determine whether the galactosylatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d47e4edf5b8bfb6c1cf35bd7913bcf
https://europepmc.org/articles/PMC1905378/

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Agalactosyl IgG in aggregates from the rheumatoid joint

Autor: Christopher J. Elson, G. C. Lastra, K. A. Leader, John R. Kirwan

Publikováno v: British journal of rheumatology. 35(4)

SUMMARY It has been postulated that agalactosyl immunoglobulin G (IgG) self-associates to form pathological aggregates in the rheumatoid joint. To examine this hypothesis, IgG aggregates from synovial fluid (SF) of 22 patients with RA were prepared b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799112306c33a6fa081bee6f14efeed5
https://pubmed.ncbi.nlm.nih.gov/8624636

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Antibody responses to the blood group antigen D in SCID mice reconstituted with human blood mononuclear cells

Autor: K A, Leader, L M, Macht, F, Steers, B M, Kumpel, C J, Elson

Publikováno v: Immunology. 76(2)

Mice with severe combined immunodeficiency (SCID) were reconstituted with peripheral blood mononuclear cells (PBMC) obtained from D-negative individuals who had been sensitized to D-positive erythrocytes. Anti-D was spontaneously secreted in mice rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::516eea3b35f9244f293bb594a38f3cd0
https://pubmed.ncbi.nlm.nih.gov/1634246

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Failure of blood mononuclear cells from human donors with autoimmune haemolytic anaemia to reconstitute severe combined immunodeficient mice

Autor: L M Macht, P Yates, Christopher J. Elson, K A Leader, R. J. Corrall

Publikováno v: Autoimmunity. 14(2)

The use of severe combined immunodeficient (SCID) mice to study humoral responses by peripheral blood mononuclear cells (PBMC) from patients with autoimmune haemolytic anaemia (AIHA) was assessed. Upon transfer to SCID mice, PBMC from normal donors a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87eeb0f6bfd506252f25d3c2b459ce49
https://pubmed.ncbi.nlm.nih.gov/1303679

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Human monoclonal anti-D with reactivity against category DVI cells used in blood grouping and determination of the incidence of the category DVI phenotype in the DU population

Autor: Anthony H. Merry, G. D. Poole, B.M. Kumpel, J. T. Kirkwood, K. A. Leader, B. A. Bradley

Publikováno v: Vox sanguinis. 58(2)

B-lymphoblastoid cell lines transformed by Epstein-Barr virus were produced from cells obtained from a hyperimmunised donor with serum anti-D activity against category DVI red cells and enriched for this activity by rosetting with category DVI red ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad4edfd0435470fc8883cedb8fb21be
https://pubmed.ncbi.nlm.nih.gov/2111059

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Akademický článek

The functional activity of FcγRII and FcγRIII on subsets of human lymphocytes.

Autor: Hadley, A. G., Zupanska, B., Kumpel, B. M., K. A. Leader

Publikováno v: Immunology; Jul92, Vol. 76 Issue 3, p446-451, 6p

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