Výsledky vyhledávání - "K A, Hogquist"

Generation of monoclonal antibodies to murine IL-1 beta and demonstration of IL-1 in vivo

Autor: K A Hogquist, M A Nett, K C Sheehan, K D Pendleton, R D Schreiber, D D Chaplin

Publikováno v: The Journal of Immunology. 146:1534-1540

The role of murine IL-1 beta in vitro and in vivo has not been defined. We describe here the production of neutralizing and immunoprecipitating mAb and polyclonal antibodies specific for murine IL-1 beta and their application to a characterization of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b1099091a70b2d2906de4adf7a82360
https://doi.org/10.4049/jimmunol.146.5.1534

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Assays of thymic selection. Fetal thymus organ culture and in vitro thymocyte dulling assay

Autor: K A, Hogquist

Publikováno v: Methods in molecular biology (Clifton, N.J.). 156

The in vitro methods of FTOC and DP dulling assay have been useful for defining the structural ligand requirements for positive selection of thymocytes. Both techniques, but especially the latter, have restrictions on their interpretation, which are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::880f6699b4aed2d986908ed0046be1f7
https://pubmed.ncbi.nlm.nih.gov/11068763

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Cutting edge: a test of the dominant negative signal model for TCR antagonism

Autor: M A, Daniels, S L, Schober, K A, Hogquist, S C, Jameson

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(7)

The mechanism by which TCR antagonists interfere with T cell activation is unclear. One popular hypothesis is that incomplete early signaling events induced by these ligands dominantly inhibit the T cell's ability to respond to a copresented agonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50f971b50ab533252bdffcf47fdc31f9
https://pubmed.ncbi.nlm.nih.gov/10201890

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Antigen-induced coreceptor down-regulation on thymocytes is not a result of apoptosis

Autor: M A, McGargill, K A, Hogquist

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(3)

The various stages of T cell development are typically characterized by the expression level of the two coreceptors, CD4 and CD8. During the CD4+CD8+ (double-positive, DP) stage of development, thymocytes that perceive a low avidity signal through th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::171ce9e96d381656dd8f4bb2b7ee0f70
https://pubmed.ncbi.nlm.nih.gov/9973375

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Development of peptide-selected CD8 T cells in fetal thymic organ culture occurs via the conventional pathway

Autor: K A, Hogquist, J L, Bonnevier

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(8)

Fetal thymic organ culture of TCR transgenic (Tg) tissue has been used to study issues of timing and specificity in T cell development. Because most TCR Tgs express a rearranged alphabeta TCR on the cell surface at an earlier stage in development tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a91cfd1a82026cdc77d7a2159772eead
https://pubmed.ncbi.nlm.nih.gov/9780155

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A positively selecting thymic epithelial cell line lacks costimulatory activity

Autor: S, Vukmanović, G, Stella, P D, King, R, Dyall, K A, Hogquist, J T, Harty, J, Nikolić-Zugić, M J, Bevan

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 152(8)

The participation of costimulatory molecule interactions in positive selection of T lymphocytes was addressed by assessing the ability of a positively selecting thymic epithelial cell (TEC) line, 427.1, to stimulate allospecific CTL responses. Stimul

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https://pubmed.ncbi.nlm.nih.gov/7511660

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IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha

Autor: A D, Howard, M J, Kostura, N, Thornberry, G J, Ding, G, Limjuco, J, Weidner, J P, Salley, K A, Hogquist, D D, Chaplin, R A, Mumford

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 147(9)

IL-1 converting enzyme (ICE) specifically cleaves the human IL-1 beta precursor at two sequence-related sites: Asp27-Gly28 (site 1) and Asp116-Ala117 (site 2). Cleavage at Asp116-Ala117 results in the generation of mature, biologically active IL-1 be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::243c982d5aa6e32beadb185117ecfa53
https://pubmed.ncbi.nlm.nih.gov/1919001

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Release of IL-1 from mononuclear phagocytes

Autor: K A, Hogquist, E R, Unanue, D D, Chaplin

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 147(7)

IL-1 alpha and -beta are 31- and 34-kDa cytokines produced by stimulated monocytes, macrophages, and a variety of other cells. These proteins are thought to function primarily as intercellular mediators and can be detected in plasma and the supernata

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https://pubmed.ncbi.nlm.nih.gov/1918954

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Generation of monoclonal antibodies to murine IL-1 beta and demonstration of IL-1 in vivo

Autor: K A, Hogquist, M A, Nett, K C, Sheehan, K D, Pendleton, R D, Schreiber, D D, Chaplin

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 146(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64c3baac2100cd986149488b4077e451
https://pubmed.ncbi.nlm.nih.gov/1993843

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