Abnormal Cellular Populations Shape Thymic Epithelial Tumor Heterogeneity and Anti‐Tumor by Blocking Metabolic Interactions in Organoids.

Autor: Liu, Xuefei^1,2,3 (AUTHOR), Wang, Changchun⁴ (AUTHOR), Huang, Yueyu¹ (AUTHOR), Lv, Qiaoli⁵ (AUTHOR), Yu, Chang⁶ (AUTHOR), Ying, Jianghua⁷ (AUTHOR), Duan, Lianhui² (AUTHOR), Guo, Yangzhong⁵ (AUTHOR), Huang, Guanyin² (AUTHOR), Shen, Wenhui¹ (AUTHOR), Jiang, Ming^8,9 (AUTHOR), Mao, Weimin^5,10 (AUTHOR) maowm@zjcc.org.cn, Zuo, Zhixiang¹¹ (AUTHOR) zuozhx@sysucc.org.cn, Zhao, An^1,5 (AUTHOR) zhaoan@zjcc.org.cn

Publikováno v: Advanced Science. 11/13/2024, Vol. 11 Issue 42, p1-18. 18p.

IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha

Autor: A D Howard, M J Kostura, N Thornberry, G J Ding, G Limjuco, J Weidner, J P Salley, K A Hogquist, D D Chaplin, R A Mumford

Publikováno v: The Journal of Immunology. 147:2964-2969

IL-1 converting enzyme (ICE) specifically cleaves the human IL-1 beta precursor at two sequence-related sites: Asp27-Gly28 (site 1) and Asp116-Ala117 (site 2). Cleavage at Asp116-Ala117 results in the generation of mature, biologically active IL-1 be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9390c4ed3030b71f1af20259254e6195
https://doi.org/10.4049/jimmunol.147.9.2964

Assays of thymic selection. Fetal thymus organ culture and in vitro thymocyte dulling assay

Autor: K A, Hogquist

Publikováno v: Methods in molecular biology (Clifton, N.J.). 156

The in vitro methods of FTOC and DP dulling assay have been useful for defining the structural ligand requirements for positive selection of thymocytes. Both techniques, but especially the latter, have restrictions on their interpretation, which are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::880f6699b4aed2d986908ed0046be1f7
https://pubmed.ncbi.nlm.nih.gov/11068763

Antigen-induced coreceptor down-regulation on thymocytes is not a result of apoptosis

Autor: M A, McGargill, K A, Hogquist

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(3)

The various stages of T cell development are typically characterized by the expression level of the two coreceptors, CD4 and CD8. During the CD4+CD8+ (double-positive, DP) stage of development, thymocytes that perceive a low avidity signal through th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::171ce9e96d381656dd8f4bb2b7ee0f70
https://pubmed.ncbi.nlm.nih.gov/9973375

Human MHC Class II and Invariant Chain Knock‐in Mice Mimic Rheumatoid Arthritis with Allele Restriction in Immune Response and Arthritis Association.

Autor: Romero‐Castillo, Laura¹ (AUTHOR) Laura.romero.castillo@ki.se, Li, Taotao¹ (AUTHOR), Do, Nhu‐Nguyen^1,2 (AUTHOR), Sareila, Outi^1,3 (AUTHOR), Xu, Bingze¹ (AUTHOR), Hennings, Viktoria⁴ (AUTHOR), Xu, Zhongwei¹ (AUTHOR), Svensson, Carolin¹ (AUTHOR), Oliveira‐Coelho, Ana¹ (AUTHOR), Sener, Zeynep¹ (AUTHOR), Urbonaviciute, Vilma¹ (AUTHOR), Ekwall, Olov⁴ (AUTHOR), Burkhardt, Harald^2,5 (AUTHOR), Holmdahl, Rikard^1,3 (AUTHOR) Rikard.holmdahl@ki.se

Publikováno v: Advanced Science. 6/19/2024, Vol. 11 Issue 23, p1-14. 14p.