[Nodal metastasis and value of neck dissection in T1/2 oropharyngeal and hypopharyngeal carcinomas].

Autor: Deuß E; Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universitätsklinikum Essen, Essen, Germany., Kürten CHL; Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universitätsklinikum Essen, Essen, Germany., Meyer M; Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universitätsklinikum Essen, Essen, Germany., Buhr CR; Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Germany., Künzel J; Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universitätsklinikum Regensburg, Regensburg, Germany., Ernst B; Klinik für Hals-Nasen-Ohrenheilkunde, Universitätsklinikum Frankfurt, Frankfurt am Main, Germany., Mattheis S; Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universitätsklinikum Essen, Essen, Germany., Lang S; Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universitätsklinikum Essen, Essen, Germany., Hussain T; Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universitätsklinikum Essen, Essen, Germany.; Klinik für Hals-, Nasen-, Ohrenheilkunde, Klinikum rechts der Isar der Technischen Universität München, München, Germany.

Publikováno v: Laryngo- rhino- otologie [Laryngorhinootologie] 2024 Jun 03. Date of Electronic Publication: 2024 Jun 03.

An individualized causal framework for learning intercellular communication networks that define microenvironments of individual tumors.

Autor: Chen X; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.; Center for Causal Discovery, University of Pittsburgh, Pennsylvania, Pittsburgh, United States of America., Chen L; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.; Center for Causal Discovery, University of Pittsburgh, Pennsylvania, Pittsburgh, United States of America., Kürten CHL; Department of Otolaryngology, University of Pittsburgh, Pennsylvania, Pittsburgh, United States of America.; University of Pittsburgh Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, University Duisburg-Essen, Duisburg, Germany., Jabbari F; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.; Center for Causal Discovery, University of Pittsburgh, Pennsylvania, Pittsburgh, United States of America., Vujanovic L; Department of Otolaryngology, University of Pittsburgh, Pennsylvania, Pittsburgh, United States of America.; University of Pittsburgh Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Ding Y; Department of Biostatistics, University of Pittsburgh, Pennsylvania, Pittsburgh, United States of America., Lu B; Department of Immunology, University of Pittsburgh, Pennsylvania, Pittsburgh, United States of America., Lu K; Williamsville North High School, Williamsville, New York, United States of America., Kulkarni A; Department of Otolaryngology, University of Pittsburgh, Pennsylvania, Pittsburgh, United States of America., Tabib T; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, University Duisburg-Essen, Duisburg, Germany., Lafyatis R; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, University Duisburg-Essen, Duisburg, Germany., Cooper GF; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.; Center for Causal Discovery, University of Pittsburgh, Pennsylvania, Pittsburgh, United States of America.; University of Pittsburgh Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Ferris R; Department of Otolaryngology, University of Pittsburgh, Pennsylvania, Pittsburgh, United States of America.; University of Pittsburgh Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Lu X; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.; Center for Causal Discovery, University of Pittsburgh, Pennsylvania, Pittsburgh, United States of America.; University of Pittsburgh Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

Publikováno v: PLoS computational biology [PLoS Comput Biol] 2022 Dec 22; Vol. 18 (12), pp. e1010761. Date of Electronic Publication: 2022 Dec 22 (Print Publication: 2022).

Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing.

Autor: Kürten CHL; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany.; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA., Kulkarni A; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA., Cillo AR; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Santos PM; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA., Roble AK; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA., Onkar S; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.; Graduate Program of Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Reeder C; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA., Lang S; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany., Chen X; Deparment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA., Duvvuri U; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA., Kim S; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA., Liu A; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., Tabib T; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Lafyatis R; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Feng J; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Virology Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Gao SJ; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Virology Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Bruno TC; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Vignali DAA; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Lu X; Deparment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA., Bao R; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Vujanovic L; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA., Ferris RL; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA. ferrisrl@upmc.edu.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. ferrisrl@upmc.edu.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA. ferrisrl@upmc.edu.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. ferrisrl@upmc.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Dec 17; Vol. 12 (1), pp. 7338. Date of Electronic Publication: 2021 Dec 17.

B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma.

Autor: Ruffin AT; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Hillman Cancer Center, Pittsburgh, PA, USA., Cillo AR; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Hillman Cancer Center, Pittsburgh, PA, USA., Tabib T; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Liu A; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA., Onkar S; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Hillman Cancer Center, Pittsburgh, PA, USA., Kunning SR; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Hillman Cancer Center, Pittsburgh, PA, USA., Lampenfeld C; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Hillman Cancer Center, Pittsburgh, PA, USA., Atiya HI; Hillman Cancer Center, Pittsburgh, PA, USA.; Division of Hematology and Oncology, Department of Medicine, Hillman Cancer Center, Pittsburgh, PA, USA., Abecassis I; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Hillman Cancer Center, Pittsburgh, PA, USA., Kürten CHL; Department of Otorhinolaryngology, University Duisburg-Essen, Essen, Germany., Qi Z; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Soose R; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA., Duvvuri U; Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Kim S; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA., Oesterrich S; Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.; Women's Cancer Research Center, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA., Lafyatis R; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA., Coffman LG; Hillman Cancer Center, Pittsburgh, PA, USA.; Division of Hematology and Oncology, Department of Medicine, Hillman Cancer Center, Pittsburgh, PA, USA., Ferris RL; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Vignali DAA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Hillman Cancer Center, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Bruno TC; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. tbruno@pitt.edu.; Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA. tbruno@pitt.edu.; Hillman Cancer Center, Pittsburgh, PA, USA. tbruno@pitt.edu.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. tbruno@pitt.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Jun 07; Vol. 12 (1), pp. 3349. Date of Electronic Publication: 2021 Jun 07.

Oral Neutrophils: Underestimated Players in Oral Cancer.

Autor: Domnich M; Department of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Riedesel J; Department of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Pylaeva E; Department of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Kürten CHL; Department of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Buer J; Institute of Medical Microbiology, University of Duisburg-Essen, Essen, Germany., Lang S; Department of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Jablonska J; Department of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Publikováno v: Frontiers in immunology [Front Immunol] 2020 Oct 09; Vol. 11, pp. 565683. Date of Electronic Publication: 2020 Oct 09 (Print Publication: 2020).