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Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies.

Autor: Silva Sousa GL; Institute of Chemistry, Universidade Federal Rural do Rio de Janeiro, Seropédica, 23897-000, Brazil., Nadur NF; Institute of Chemistry, Universidade Federal Rural do Rio de Janeiro, Seropédica, 23897-000, Brazil., de Almeida Peixoto Ferreira L; Institute of Chemistry, Universidade Federal Rural do Rio de Janeiro, Seropédica, 23897-000, Brazil., da Silva Honório T; Cell Culture Laboratory (LabCel), Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil., Simon A; Cell Culture Laboratory (LabCel), Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil., Cabral LM; Cell Culture Laboratory (LabCel), Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil., Móra Santos ML; Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, 21941-902, Brazil., Andrade B; Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, 21941-902, Brazil., de Lima EV; Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, 21941-902, Brazil., Clarke JR; Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, 21941-902, Brazil., Castro RN; Institute of Chemistry, Universidade Federal Rural do Rio de Janeiro, Seropédica, 23897-000, Brazil., Olímpio de Moura R; Department of Chemistry, Universidade Estadual da Paraíba, Campina Grande, 58429-500, Brazil., Kümmerle AE; Institute of Chemistry, Universidade Federal Rural do Rio de Janeiro, Seropédica, 23897-000, Brazil. Electronic address: akummerle@ufrrj.br.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Nov 07; Vol. 281, pp. 117030. Date of Electronic Publication: 2024 Nov 07.

Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation.

Autor: Cristancho Ortiz CJ; PeQuiM-Laboratory of Research in Medicinal Chemistry, Federal University of Alfenas 2600 Jovino Fernandes Sales Ave. Alfenas MG 37130-840 Brazil cvjviegas@gmail.com., de Freitas Silva M; PeQuiM-Laboratory of Research in Medicinal Chemistry, Federal University of Alfenas 2600 Jovino Fernandes Sales Ave. Alfenas MG 37130-840 Brazil cvjviegas@gmail.com., Pruccoli L; Department for Life Quality Studies, University of Bologna'Alma Mater Studiorum' 237 Corso d'Augusto St. 47921 Rimini Italy andrea.tarozzi@unibo.it., Fonseca Nadur N; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro 21941-902 Seropédica RJ Brazil., de Azevedo LL; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro 21941-902 Seropédica RJ Brazil., Kümmerle AE; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro 21941-902 Seropédica RJ Brazil., Guedes IA; National Laboratory for Scientific Computing 25651-075 Petrópolis RJ Brazil., Dardenne LE; National Laboratory for Scientific Computing 25651-075 Petrópolis RJ Brazil., Leomil Coelho LF; Institute of Biomedical Sciences, Federal University of Alfenas 700 Gabriel Monteiro da Silva St Alfenas MG 37130-840 Brazil., Guimarães MJ; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro 21941-902 Rio de Janeiro/RJ Brazil., da Silva FMR; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro 21941-902 Rio de Janeiro/RJ Brazil., Castro N; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro 21941-902 Rio de Janeiro/RJ Brazil., Gontijo VS; PeQuiM-Laboratory of Research in Medicinal Chemistry, Federal University of Alfenas 2600 Jovino Fernandes Sales Ave. Alfenas MG 37130-840 Brazil cvjviegas@gmail.com., Rojas VCT; Laboratory of Physiology, Federal University of Alfenas 2600 Jovino Fernandes Sales Avenue Alfenas MG 37130-840 Brazil., de Oliveira MK; Laboratory of Physiology, Federal University of Alfenas 2600 Jovino Fernandes Sales Avenue Alfenas MG 37130-840 Brazil., Vilela FC; Laboratory of Physiology, Federal University of Alfenas 2600 Jovino Fernandes Sales Avenue Alfenas MG 37130-840 Brazil., Giusti-Paiva A; Laboratory of Physiology, Federal University of Alfenas 2600 Jovino Fernandes Sales Avenue Alfenas MG 37130-840 Brazil., Barbosa G; LASSBio - Laboratório de Avaliação e Síntese de Substâncias Bioativas, Health Sciences Center, Federal University of Rio de Janeiro 21941-902 Rio de Janeiro/RJ Brazil., Lima LM; LASSBio - Laboratório de Avaliação e Síntese de Substâncias Bioativas, Health Sciences Center, Federal University of Rio de Janeiro 21941-902 Rio de Janeiro/RJ Brazil., Pinheiro GB; Laboratory of Neuropharmacology, Institute of Biological Sciences, University of Brasília Brasilia DF 70910-900 Brazil., Veras LG; Laboratory of Neuropharmacology, Institute of Biological Sciences, University of Brasília Brasilia DF 70910-900 Brazil., Mortari MR; Laboratory of Neuropharmacology, Institute of Biological Sciences, University of Brasília Brasilia DF 70910-900 Brazil., Tarozzi A; PeQuiM-Laboratory of Research in Medicinal Chemistry, Federal University of Alfenas 2600 Jovino Fernandes Sales Ave. Alfenas MG 37130-840 Brazil cvjviegas@gmail.com.; Department for Life Quality Studies, University of Bologna'Alma Mater Studiorum' 237 Corso d'Augusto St. 47921 Rimini Italy andrea.tarozzi@unibo.it., Viegas C Jr; PeQuiM-Laboratory of Research in Medicinal Chemistry, Federal University of Alfenas 2600 Jovino Fernandes Sales Ave. Alfenas MG 37130-840 Brazil cvjviegas@gmail.com.

Publikováno v: RSC medicinal chemistry [RSC Med Chem] 2022 Mar 17; Vol. 13 (5), pp. 568-584. Date of Electronic Publication: 2022 Mar 17 (Print Publication: 2022).

Antiprotozoal agents: How have they changed over a decade?

Autor: Fernandes VS; Department of Pharmaceutical Sciences, Pharmaceutical and Medicinal Chemistry Laboratory, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil., da Rosa R; Department of Organic Chemistry, Medicinal Chemistry and Molecular Diversity Laboratory, Federal Rural University of Rio de Janeiro, Seropédica, Rio de Janeiro, Brazil., Zimmermann LA; Department of Organic Chemistry, Medicinal Chemistry and Molecular Diversity Laboratory, Federal Rural University of Rio de Janeiro, Seropédica, Rio de Janeiro, Brazil., Rogério KR; Department of Pharmaceutical Sciences, Pharmaceutical and Medicinal Chemistry Laboratory, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil., Kümmerle AE; Department of Pharmaceutical Sciences, Pharmaceutical and Medicinal Chemistry Laboratory, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil., Bernardes LSC; Department of Organic Chemistry, Medicinal Chemistry and Molecular Diversity Laboratory, Federal Rural University of Rio de Janeiro, Seropédica, Rio de Janeiro, Brazil., Graebin CS; Department of Pharmaceutical Sciences, Pharmaceutical and Medicinal Chemistry Laboratory, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2022 Feb; Vol. 355 (2), pp. e2100338. Date of Electronic Publication: 2021 Oct 18.

Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases.

Autor: Ortiz CJC; PeQuiM-Laboratory of Research in Medicinal Chemistry, Federal University of Alfenas, Jovino Fernandes Sales Avenue 2600, Alfenas, MG, 37130-840, Brazil., Damasio CM; PeQuiM-Laboratory of Research in Medicinal Chemistry, Federal University of Alfenas, Jovino Fernandes Sales Avenue 2600, Alfenas, MG, 37130-840, Brazil., Pruccoli L; Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Corso d'Augusto 237, 47921, Rimini, Italy., Nadur NF; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio De Janeiro, RJ, 21941-902, Brazil., de Azevedo LL; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio De Janeiro, RJ, 21941-902, Brazil., Guedes IA; National Laboratory of Scientific Computation, Petrópolis, RJ, 25651-075, Brazil., Dardenne LE; National Laboratory of Scientific Computation, Petrópolis, RJ, 25651-075, Brazil., Kümmerle AE; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio De Janeiro, RJ, 21941-902, Brazil., Tarozzi A; Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Corso d'Augusto 237, 47921, Rimini, Italy. andrea.tarozzi@unibo.it., Viegas C Jr; PeQuiM-Laboratory of Research in Medicinal Chemistry, Federal University of Alfenas, Jovino Fernandes Sales Avenue 2600, Alfenas, MG, 37130-840, Brazil. cvjviegas@gmail.com.

Publikováno v: Neurochemical research [Neurochem Res] 2020 Dec; Vol. 45 (12), pp. 3003-3020. Date of Electronic Publication: 2020 Oct 20.