Human endometrial cell-type-specific RNA sequencing provides new insights into the embryo-endometrium interplay

Autor: Mariann Koel, Kaarel Krjutškov, Merli Saare, Külli Samuel, Dmitri Lubenets, Shintaro Katayama, Elisabet Einarsdottir, Eva Vargas, Alberto Sola-Leyva, Parameswaran Grace Lalitkumar, Kristina Gemzell-Danielsson, David Blesa, Carlos Simon, Fredrik Lanner, Juha Kere, Andres Salumets, Signe Altmäe

Publikováno v: Human Reproduction Open

STUDY QUESTION: Which genes regulate receptivity in the epithelial and stromal cellular compartments of the human endometrium, and which molecules are interacting in the implantation process between the blastocyst and the endometrial cells? SUMMARY A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc5942b0be33d9ebb066f568f279f0b
http://hdl.handle.net/10138/351512

Differentially-Expressed miRNAs in Ectopic Stromal Cells Contribute to Endometriosis Development: The Plausible Role of miR-139-5p and miR-375

Autor: Kadri Rekker, Tõnis Tasa, Merli Saare, Külli Samuel, Ülle Kadastik, Helle Karro, Martin Götte, Andres Salumets, Maire Peters

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 12, p 3789 (2018)

microRNA (miRNA) expression level alterations between endometrial tissue and endometriotic lesions indicate their involvement in endometriosis pathogenesis. However, as both endometrium and endometriotic lesions consist of different cell types in var

Externí odkaz: https://doaj.org/article/6df0366c47ae4500bf749b1aa83333c3

Deep Quantitative Proteomics Reveals Extensive Metabolic Reprogramming and Cancer-Like Changes of Ectopic Endometriotic Stromal Cells

Autor: Lee Padrik, Lauri Peil, Maire Peters, Sergo Kasvandik, Külli Samuel, Andres Salumets, Anne Mari Roost, Margus Eimre, Nadežda Peet, Kalju Paju

Publikováno v: Journal of Proteome Research. 15:572-584

Endometriosis is a prevalent health condition in women of reproductive age characterized by ectopic growth of endometrial-like tissue in the extrauterine environment. Thorough understanding of the molecular mechanisms underlying the disease is still

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c49514ccbe80969a9d7406d869569ae
https://doi.org/10.1021/acs.jproteome.5b00965

High-throughput mRNA sequencing of stromal cells from endometriomas and endometrium

Autor: Andres Salumets, Helle Karro, Külli Samuel, Viktorija Kukuškina, Elo Eriste, Maire Peters, Anne Mari Roost, Tõnis Tasa, Kadri Rekker, Merli Saare, Kristi Anderson

Publikováno v: Reproduction

The aetiology of endometriosis is still unclear and to find mechanisms behind the disease development, it is important to study each cell type from endometrium and ectopic lesions independently. The objective of this study was to uncover complete mRN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c6c7298c4e181f58c4d362250a6f74
https://doi.org/10.1530/REP-17-0092

Characterisation of probiotic properties in human vaginal lactobacilli strains

Autor: Reet Mändar, Heleri Taelma, Külli Samuel, Andreas Salumets, Jelena Štšepetova, Pirje Hütt, Helen Oopkaup, Natalja Borovkova, Imbi Smidt, Tiiu Rööp, Eleri Lapp, Dagmar Hoidmets, Ave Ahelik

Publikováno v: Microbial Ecology in Health and Disease
Microbial Ecology in Health and Disease; Vol 27 (2016)
Microbial Ecology in Health and Disease, Vol 27, Iss 0, Pp 1-9 (2016)

Background : Vaginal lactobacilli offer protection against recurrent urinary infections, bacterial vaginosis, and vaginal candidiasis. Objective : To characterise the isolated vaginal lactobacilli strains for their probiotic properties and to compare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5c1139f2af2ce01d41091532b75315
https://pubmed.ncbi.nlm.nih.gov/27527701