PharmoCo: a graph-based visualization of pharmacogenomic plausibility check reports for clinical decision support systems

Autor: Raupach Lena, Königs Cassandra

Publikováno v: Journal of Integrative Bioinformatics, Vol 20, Iss 4, Pp 1189976-90 (2023)

The first approaches in recent years for the integration of pharmacogenomic plausibility checks into clinical practice show both a promising improvement in the drug therapy safety, but also difficulties in application. One of the difficulties is the

Externí odkaz: https://doaj.org/article/4e6fd2bfc3b84c0593b2ad8320982495

A web-based pathway enrichment analysis module for the PharMeBINet database.

Autor: Königs, Cassandra¹ (AUTHOR) c.koenigs@uni-bielefeld.de, Dietrich, Theresa¹ (AUTHOR)

Publikováno v: GMS Medizinische Informatik, Biometrie und Epidemiologie. 2023, Vol. 19, p1-14. 14p.

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Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects

Autor: Zolotareva, Olga, Saik, Olga V., Königs, Cassandra, Bragina, Elena Yu., Goncharova, Irina A., Freidin, Maxim B., Dosenko, Victor E., Ivanisenko, Vladimir A., Hofestädt, Ralf

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports

Asthma and hypertension are complex diseases coinciding more frequently than expected by chance. Unraveling the mechanisms of comorbidity of asthma and hypertension is necessary for choosing the most appropriate treatment plan for patients with this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::94c2ddb235857ffb9091f696bba075fa
http://link.springer.com/article/10.1038/s41598-019-52762-w

Exploration of molecular risk modifying factors for adverse drug reactions

Autor: Kleine, Maren, Shoshi, Alban, Königs, Cassandra, Maier, Alex, Zolotareva, Olga, Hofestaedt, Ralf

Publikováno v: 63. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS); 20180902-20180906; Osnabrück; DOCAbstr. 117 /20180827/

Background: The causal analysis of potential adverse drug reactions (ADRs) is verychallenging due to their mechanistic complexity (multiple genes, genetic variations, proteins, and their interaction are relevant) [ref:7]. To investigate the cause of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc23a57b92f9be547588137fc835cc32
http://www.egms.de/en/meetings/gmds2018/18gmds161.shtml