A web-based pathway enrichment analysis module for the PharMeBINet database

Autor: Königs, Cassandra, Dietrich, Theresa

Publikováno v: GMS Medizinische Informatik, Biometrie und Epidemiologie, Vol 19, p Doc04 (2023)

In modern molecular biology, the quantification of proteins, RNA, and DNA is a standard procedure. Resulting in the generation of large data, researchers need appropriate tools for interpretation. A common method for interpreting gene expression data

Externí odkaz: https://doaj.org/article/3a0ed694d5124db3a8a4c53a9af7cf0c

PharmoCo: a graph-based visualization of pharmacogenomic plausibility check reports for clinical decision support systems.

Autor: Raupach, Lena, Königs, Cassandra

Publikováno v: Journal of Integrative Bioinformatics; Dec2023, Vol. 20 Issue 4, p1-10, 10p

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Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects

Autor: Zolotareva, Olga, Saik, Olga V., Königs, Cassandra, Bragina, Elena Yu., Goncharova, Irina A., Freidin, Maxim B., Dosenko, Victor E., Ivanisenko, Vladimir A., Hofestädt, Ralf

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports

Asthma and hypertension are complex diseases coinciding more frequently than expected by chance. Unraveling the mechanisms of comorbidity of asthma and hypertension is necessary for choosing the most appropriate treatment plan for patients with this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::94c2ddb235857ffb9091f696bba075fa
http://link.springer.com/article/10.1038/s41598-019-52762-w

Exploration of molecular risk modifying factors for adverse drug reactions

Autor: Kleine, Maren, Shoshi, Alban, Königs, Cassandra, Maier, Alex, Zolotareva, Olga, Hofestaedt, Ralf

Publikováno v: 63. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS); 20180902-20180906; Osnabrück; DOCAbstr. 117 /20180827/

Background: The causal analysis of potential adverse drug reactions (ADRs) is verychallenging due to their mechanistic complexity (multiple genes, genetic variations, proteins, and their interaction are relevant) [ref:7]. To investigate the cause of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc23a57b92f9be547588137fc835cc32
http://www.egms.de/en/meetings/gmds2018/18gmds161.shtml