The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP.

Autor: Ambjørner SEB; Department of Drug Design and Pharmacology, University of Copenhagen, 1165 Copenhagen, Denmark., Wiese M; Pharmaceutical Institute, University of Bonn, 53113 Bonn, Germany., Köhler SC; Pharmaceutical Institute, University of Bonn, 53113 Bonn, Germany., Svindt J; Department of Biology, University of Copenhagen, 1165 Copenhagen, Denmark., Lund XL; Department of Drug Design and Pharmacology, University of Copenhagen, 1165 Copenhagen, Denmark., Gajhede M; Department of Drug Design and Pharmacology, University of Copenhagen, 1165 Copenhagen, Denmark., Saaby L; Department of Pharmacy, University of Copenhagen, 1165 Copenhagen, Denmark., Brodin B; Department of Pharmacy, University of Copenhagen, 1165 Copenhagen, Denmark., Rump S; SRConsulting, 31319 Sehnde, Germany., Weigt H; Division of Chemical Safety and Toxicity, Fraunhofer Institute of Toxicology and Experimental Medicine, 30625 Hannover, Germany., Brünner N; Department of Drug Design and Pharmacology, University of Copenhagen, 1165 Copenhagen, Denmark.; Scandion Oncology A/S, Symbion, 2100 Copenhagen, Denmark., Stenvang J; Department of Drug Design and Pharmacology, University of Copenhagen, 1165 Copenhagen, Denmark.; Scandion Oncology A/S, Symbion, 2100 Copenhagen, Denmark.

Publikováno v: Cells [Cells] 2020 Mar 04; Vol. 9 (3). Date of Electronic Publication: 2020 Mar 04.

Synthesis of Homoverrucosanoid-Derived Esters and Evaluation as MDR Modulators.

Autor: Schäfer A; Fakultät für Chemie und Chemische Biologie, Technische Universität Dortmund , 44227 Dortmund, Germany., Köhler SC; Pharmazeutisches Institut, Pharmazeutische Chemie II, Universität Bonn , 53121 Bonn, Germany., Lohe M; Fakultät für Chemie und Chemische Biologie, Technische Universität Dortmund , 44227 Dortmund, Germany., Wiese M; Pharmazeutisches Institut, Pharmazeutische Chemie II, Universität Bonn , 53121 Bonn, Germany., Hiersemann M; Fakultät für Chemie und Chemische Biologie, Technische Universität Dortmund , 44227 Dortmund, Germany.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2017 Oct 06; Vol. 82 (19), pp. 10504-10522. Date of Electronic Publication: 2017 Sep 26.

Optimization of Acryloylphenylcarboxamides as Inhibitors of ABCG2 and Comparison with Acryloylphenylcarboxylates.

Autor: Kraege S; Pharmaceutical Chemistry II, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany., Stefan K; Pharmaceutical Chemistry II, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany., Köhler SC; Pharmaceutical Chemistry II, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany., Wiese M; Pharmaceutical Chemistry II, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.

Publikováno v: ChemMedChem [ChemMedChem] 2016 Nov 21; Vol. 11 (22), pp. 2547-2558. Date of Electronic Publication: 2016 Oct 27.

HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2).

Autor: Köhler SC; Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany., Wiese M; Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 May 14; Vol. 58 (9), pp. 3910-21. Date of Electronic Publication: 2015 Apr 24.