Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Kévin Ly"'
Autor:
Yi Zhang, Miso Park, Lucy Y. Ghoda, Dandan Zhao, Melissa Valerio, Ebtesam Nafie, Asaul Gonzalez, Kevin Ly, Bea Parcutela, Hyeran Choi, Xubo Gong, Fang Chen, Kaito Harada, Zhenhua Chen, Le Xuan Truong Nguyen, Flavia Pichiorri, Jianjun Chen, Joo Song, Stephen J. Forman, Idoroenyi Amanam, Bin Zhang, Jie Jin, John C. Williams, Guido Marcucci
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-18 (2024)
Abstract Background The interleukin-1 receptor accessory protein (IL1RAP) is highly expressed on acute myeloid leukemia (AML) bulk blasts and leukemic stem cells (LSCs), but not on normal hematopoietic stem cells (HSCs), providing an opportunity to t
Externí odkaz:
https://doaj.org/article/81c6c4a1c88f4c5d9d2eee24813cc8c0
Autor:
Kévin Ly, Hugo Gagnon, Pauline Navals, Yves L. Dory, Anna Kwiatkowska, Monika A Lewandowska-Goch, Adam Prahl, Teresa Łepek, Robert Day
Publikováno v:
ACS Med Chem Lett
Furin plays an important role in various pathological states, especially in bacterial and viral infections A detailed understanding of the structural requirements for inhibitors targeting this enzyme is crucial to develop new therapeutic strategies i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee64ddce4e872ccbea57dd6deeaf61e3
https://doi.org/10.1021/acsmedchemlett.0c00386
https://doi.org/10.1021/acsmedchemlett.0c00386
Autor:
Ali Ben Djoudi Ouadda, Benoit Coulombe, Rachid Essalmani, Robert Day, Artuela Çaku, Luc Galarneau, Delia Susan-Resiga, Kévin Ly, Emmanuelle Girard, Jadwiga Marcinkiewicz, Nabil G. Seidah, Miles H. Black, Diane Forget, François Corbin, Vincent S. Tagliabracci, Josée Hamelin, Alexandra Evagelidis, Marie-Soleil Gauthier
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: PCSK9 (proprotein convertase subtilisin-kexin 9) enhances the degradation of the LDLR (low-density lipoprotein receptor) in endosomes/lysosomes. This study aimed to determine the sites of PCSK9 phosphorylation at Ser-residues and the conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40bfa73619a7a4a54a0647be1a0ddb0
https://doi.org/10.1161/atvbaha.119.313247
https://doi.org/10.1161/atvbaha.119.313247
Autor:
Talal El Zarif, Karl Semaan, Marc Eid, Ji-Heui Seo, Simon Garinet, Matthew P. Davidsohn, Pranshu Sahgal, Brad Fortunato, John Canniff, Amin H. Nassar, Sarah Abou Alaiwi, Ziad Bakouny, Gitanjali Lakshminarayanan, Hunter Savignano, Kevin Lyons, Sayed Matar, Atef Ali, Eddy Saad, Renee Maria Saliby, Paulo Cordeiro, Ziwei Zhang, Nourhan El Ahmar, Yasmin Nabil Laimon, Chris Labaki, Valisha Shah, Dory Freeman, Jillian O’Toole, Gwo-Shu Mary Lee, Justin Hwang, Mark Pomerantz, Sabina Signoretti, Eliezer M. Van Allen, Wanling Xie, Jacob E. Berchuck, Srinivas R. Viswanathan, David A. Braun, Toni K. Choueiri, Matthew L. Freedman, Sylvan C. Baca
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114350- (2024)
Summary: Renal cell carcinoma with sarcomatoid differentiation (sRCC) is associated with poor survival and a heightened response to immune checkpoint inhibitors (ICIs). Two major barriers to improving outcomes for sRCC are the limited understanding o
Externí odkaz:
https://doaj.org/article/a9e18e74ab10487c9c8418746dfe9c2a
Autor:
Kévin Ly, Anna Kwiatkowska, Christine Levesque, Robert Day, Adam Prahl, Roxane Desjardins, Witold Neugebauer, Frédéric Couture, Izabela Małuch
Publikováno v:
Journal of Medicinal Chemistry. 60:2732-2744
The proprotein convertase family of enzymes includes seven endoproteases with significant redundancy in their cleavage activity. We previously described the peptide Ac-LLLLRVK-Amba that displays potent inhibitory effects on both PACE4 and prostate ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0284a456fb1ec33bae29b9983a41a6bd
https://doi.org/10.1021/acs.jmedchem.6b01499
https://doi.org/10.1021/acs.jmedchem.6b01499
Autor:
Neha A. Sathe, Su Xian, F. Linzee Mabrey, David R. Crosslin, Sean D. Mooney, Eric D. Morrell, Kevin Lybarger, Meliha Yetisgen, Gail P. Jarvik, Pavan K. Bhatraju, Mark M. Wurfel
Publikováno v:
BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background Evolving ARDS epidemiology and management during COVID-19 have prompted calls to reexamine the construct validity of Berlin criteria, which have been rarely evaluated in real-world data. We developed a Berlin ARDS definition (EHR-
Externí odkaz:
https://doaj.org/article/fa88bb75be1c42fa943455768a04a123
Autor:
Celine Ann Fox, Chi Tak Lee, Anna Kathleen Hanlon, Tricia XF Seow, Kevin Lynch, Siobhán Harty, Derek Richards, Jorge Palacios, Veronica O'Keane, Klaas Enno Stephan, Claire M Gillan
Publikováno v:
eLife, Vol 12 (2023)
Prior studies have found metacognitive biases are linked to a transdiagnostic dimension of anxious-depression, manifesting as reduced confidence in performance. However, previous work has been cross-sectional and so it is unclear if under-confidence
Externí odkaz:
https://doaj.org/article/bc1e941667f8405ab05ec1d458871c36
Autor:
Matthew R. Short, Daniel Ludvig, Emek Baris Kucuktabak, Yue Wen, Lorenzo Vianello, Eric J. Perreault, Levi Hargrove, Kevin Lynch, Jose L. Pons
Publikováno v:
IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol 31, Pp 3864-3873 (2023)
While treating sensorimotor impairments, a therapist may provide physical assistance by guiding their patient’s limb to teach a desired movement. In this scenario, a key aspect is the compliance of the interaction, as the therapist can provide subt
Externí odkaz:
https://doaj.org/article/a730696e97e7484786f4ee4e230755c3
Autor:
Sangjoon J. Kim, Yue Wen, Daniel Ludvig, Emek Baris Kucuktabak, Matthew R. Short, Kevin Lynch, Levi Hargrove, Eric J. Perreault, Jose L. Pons
Publikováno v:
IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol 31, Pp 416-425 (2023)
Optimizing skill acquisition during novel motor tasks and regaining lost motor functions have been the interest of many researchers over the past few decades. One approach shown to accelerate motor learning involves haptically coupling two individual
Externí odkaz:
https://doaj.org/article/eafa78c031ab4f44b30e8b30ed159f48
Autor:
Chi Tak Lee, Jorge Palacios, Derek Richards, Anna K. Hanlon, Kevin Lynch, Siobhan Harty, Nathalie Claus, Lorraine Swords, Veronica O’Keane, Klaas E Stephan, Claire M Gillan
Publikováno v:
BMC Psychiatry, Vol 23, Iss 1, Pp 1-19 (2023)
Abstract Background Evidence-based treatments for depression exist but not all patients benefit from them. Efforts to develop predictive models that can assist clinicians in allocating treatments are ongoing, but there are major issues with acquiring
Externí odkaz:
https://doaj.org/article/1303c348921c48da9a1f98c4b953d8ea