Quantitative proteomics identifies reduced NRF2 activity and mitochondrial dysfunction in Atopic Dermatitis

Autor: Michael Koch, Tobias Kockmann, Elke Rodriguez, Ulrike Wehkamp, Paul Hiebert, Maya Ben-Yehuda Greenwald, Dora Stölzl, Hans-Dietmar Beer, Erwin Tschachler, Stephan Weidinger, Sabine Werner, Ulrich Auf dem Keller

Publikováno v: Koch, M, Kockmann, T, Rodriguez, E, Wehkamp, U, Hiebert, P, Ben-Yehuda Greenwald, M, Stölzl, D, Beer, H-D, Tschachler, E, Weidinger, S, Werner, S & auf dem Keller, U 2023, ' Quantitative proteomics identifies reduced NRF2 activity and mitochondrial dysfunction in Atopic Dermatitis ', Journal of Investigative Dermatology, vol. 143, no. 2, pp. 220-237.e7 . https://doi.org/10.1016/j.jid.2022.08.048
Journal of Investigative Dermatology, 143 (2)

Atopic dermatitis is the most common inflammatory skin disease and is characterized by a deficient epidermal barrier and cutaneous inflammation. Genetic studies suggest a key role of keratinocytes in atopic dermatitis pathogenesis, but the alteration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b87ecb94d48f8822feeb7012eff45a0
https://www.zora.uzh.ch/id/eprint/227346/

Unlocking the Mechanisms of Cutaneous Adverse Drug Reactions: Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway by EGFR Inhibitors Triggers Keratinocyte Differentiation and Polarization of Epidermal Immune Responses

Autor: Georgios N. Stamatas, Thomas Ondet, Mario Monshouwer, Pierre-François Roux

Publikováno v: JID Innovations
JID Innovations, Vol 1, Iss 2, Pp 100009-(2021)

EGFR inhibitors used in oncology therapy modify the keratinocyte differentiation processes, impairing proper skin barrier formation and leading to cutaneous adverse drug reactions. To uncover the molecular signatures associated with cutaneous adverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86691b3a1b900b415da33bfa5e7871c9
https://pubmed.ncbi.nlm.nih.gov/34909713

Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed CellsSummary

Autor: Nicolai Lehnert, Dhiman Maitra, Stephen W. Ragsdale, Laure Rittié, M. Bishr Omary, Alexey I. Nesvizhskii, Haoming Zhang, Matthew W. Wolf, Harald Herrmann, Venkatesha Basrur, Rani Richardson, Yoichi Osawa, Eric L. Carter

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 4, Pp 659-682.e1 (2019)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Porphyrias are caused by porphyrin accumulation resulting from defects in the heme biosynthetic pathway that typically lead to photosensitivity and possible end-stage liver disease with an increased risk of hepatocellular carcinoma.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0592cf3cff3ae349fa52696e431bb166
http://www.sciencedirect.com/science/article/pii/S2352345X19300724

Vascular endothelial growth factor driving aberrant keratin expression pattern contributes to the pathogenesis of psoriasis.

Autor: Jiang, Man¹, Li, Bing¹, Zhang, Jieyu¹, Hu, Lei¹, Dang, Erle¹, Wang, Gang¹ xjwgang@fmmu.edu.cn

Publikováno v: Experimental Cell Research. Nov2017, Vol. 360 Issue 2, p310-319. 10p.

ABHD1 Facilitates Intermediate Filament–Mediated Endothelial Cell Chemotaxis by Regulating KRT1 and KRT2 in Diabetic Retinopathy.

Autor: Liu, Xinyi^1,2,3,4,5 (AUTHOR), Fang, Junwei^1,2,3,4,5 (AUTHOR), Niu, Tian^1,2,3,4,5 (AUTHOR), Xing, Xindan^1,2,3,4,5 (AUTHOR), Shi, Xin^1,2,3,4,5 (AUTHOR), Xiao, Yu^1,2,3,4,5 (AUTHOR), Qu, Yuan^1,2,3,4,5 (AUTHOR), Jiang, Yan^1,2,3,4,5 (AUTHOR), Lv, Kangjia^1,2,3,4,5 (AUTHOR), Dou, Tianyu^1,2,3,4,5 (AUTHOR), Zhu, Qian^1,2,3,4,5 (AUTHOR), Wan, Hancong^1,2,3,4,5 (AUTHOR), Liu, Xiaoxin^1,2,3,4,5 (AUTHOR), Wang, Hanying^1,2,3,4,5 (AUTHOR) hanyingwang_sjtu@163.com, Liu, Kun^1,2,3,4,5 (AUTHOR) drliukun@sjtu.edu.cn, Catrina, Sergiu (AUTHOR) sergiu-bogdan.catrina@ki.se

Publikováno v: Journal of Diabetes Research. 11/20/2024, Vol. 2024, p1-12. 12p.