Zobrazeno 1 - 10
of 336
pro vyhledávání: '"K, Witting"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7863 (2024)
Acute-phase serum amyloid A (SAA) can disrupt vascular homeostasis and is elevated in subjects with diabetes, cardiovascular disease, and rheumatoid arthritis. Cyclic nitroxides (e.g., Tempo) are a class of piperidines that inhibit oxidative stress a
Externí odkaz:
https://doaj.org/article/5fb50fc0be6747e58ffa8575a9b8af07
Autor:
Tamara Ortiz-Cerda, Federico Argüelles-Arias, Laura Macías-García, Victoria Vázquez-Román, Gladys Tapia, Kangzhe Xie, María Desirée García-García, Manuel Merinero, Josefa-María García-Montes, Ana Alcudia, Paul K. Witting, Manuel De-Miguel
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionCrohn’s disease (CD) involves activation of mast cells (MC) and NF-кB in parallel with the PPAR-α/NLRP3 inflammasome/IL-1β pathway in the inflamed colon. Whether polyphenols from maqui (Aristotelia chilensis) represent a natural alte
Externí odkaz:
https://doaj.org/article/b9059c4a3be54cd3ba558db11889bd7f
Autor:
Patrick T. San Gabriel, Thomas R. O’Neil, Alice Au, Jian K. Tan, Gabriela V. Pinget, Yuyang Liu, Genevieve Fong, Jacqueline Ku, Elias Glaros, Laurence Macia, Paul K. Witting, Shane R. Thomas, Belal Chami
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4258 (2024)
Neutrophil-myeloperoxidase (MPO) is a heme-containing peroxidase which produces excess amounts of hypochlorous acid during inflammation. While pharmacological MPO inhibition mitigates all indices of experimental colitis, no studies have corroborated
Externí odkaz:
https://doaj.org/article/f31e89a4fabc4ba4a937df683ac62071
Autor:
Yutang Wang, Yan Fang, Paul K. Witting, Fadi J. Charchar, Christopher G. Sobey, Grant R. Drummond, Jonathan Golledge
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract We investigated the association of dietary intake of major types of fatty acids with heart disease mortality in a general adult cohort with or without a prior diagnosis of myocardial infarction (MI). This cohort study included US adults who
Externí odkaz:
https://doaj.org/article/cd667d8323c24547a74a513029945114
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1873 (2023)
Metazoan signalling pathways can be rewired to dampen or amplify the rate of events, such as those that occur in development and aging. Given that a linear network topology restricts the capacity to rewire signalling pathways, such scalability of the
Externí odkaz:
https://doaj.org/article/ba92bc202a4d44ce899279c37ce07555
Autor:
Maria Parvaneh, Paul K. Witting, Jaqueline Ku, Tala Moradi, Elif Eroglu, Ben Freedman, Greg T. Sutherland, Andrew McCorkindale, Boris Guennewig, Phannaphat Choowong, Kim Bell-Anderson, Gregory Cooney, Shane R. Thomas, Joerg Eberhard
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The treatment of periodontitis has numerous positive effects on established chronic health conditions, including cardiovascular disease and diabetes. However, ethical considerations do limit the establishment of human trials to investigate w
Externí odkaz:
https://doaj.org/article/3290d562eb7d40e5b7d7eca71b22cb2f
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7725 (2023)
Innate and adaptive immune responses comprise a complex network of protein–protein and protein–cell interactions that regulates commensal flora and protects organisms from foreign pathogens and transformed (proliferating) host cells under physiol
Externí odkaz:
https://doaj.org/article/5a915765ba104978b4b3b922ac7826a2
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6068 (2023)
Dietary selenium (Se) intake within the physiological range is critical to maintain various biological functions, including antioxidant defence, redox homeostasis, growth, reproduction, immunity, and thyroid hormone production. Chemical forms of diet
Externí odkaz:
https://doaj.org/article/88ad05d7648945779a93d2941e787913
Autor:
Yutang Wang, Dinh Tam Nguyen, Jack Anesi, Ahmed Alramahi, Paul K. Witting, Zhonglin Chai, Abdul Waheed Khan, Jason Kelly, Kate M. Denton, Jonathan Golledge
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3857 (2023)
This study aimed to investigate the effect of the sympatholytic drug moxonidine on atherosclerosis. The effects of moxonidine on oxidised low-density lipoprotein (LDL) uptake, inflammatory gene expression and cellular migration were investigated in v
Externí odkaz:
https://doaj.org/article/fc2f1dd2f5c24d93965b98b3a30df961
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 6923 (2022)
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that arises due to a complex and variable interplay between elements including age, genetic, and environmental risk factors that manifest as the loss of dopaminergic neurons. Cont
Externí odkaz:
https://doaj.org/article/19997f171fc74e429696633666f4e450