Zobrazeno 1 - 10
of 249
pro vyhledávání: '"K, Wasson"'
Autor:
Gabriela Venturini, Juliana M. Alvim, Kallyandra Padilha, Christopher N. Toepfer, Joshua M. Gorham, Lauren K. Wasson, Diogo Biagi, Sergio Schenkman, Valdemir M. Carvalho, Jessica S. Salgueiro, Karina H. M. Cardozo, Jose E. Krieger, Alexandre C. Pereira, Jonathan G. Seidman, Christine E. Seidman
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionChagas cardiomyopathy, a disease caused by Trypanosoma cruzi (T. cruzi) infection, is a major contributor to heart failure in Latin America. There are significant gaps in our understanding of the mechanism for infection of human cardiomyo
Externí odkaz:
https://doaj.org/article/dd5e4d9e31404b4a8296661ca7c6392c
GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm
Autor:
Arun Sharma, Lauren K Wasson, Jon AL Willcox, Sarah U Morton, Joshua M Gorham, Daniel M DeLaughter, Meraj Neyazi, Manuel Schmid, Radhika Agarwal, Min Young Jang, Christopher N Toepfer, Tarsha Ward, Yuri Kim, Alexandre C Pereira, Steven R DePalma, Angela Tai, Seongwon Kim, David Conner, Daniel Bernstein, Bruce D Gelb, Wendy K Chung, Elizabeth Goldmuntz, George Porter, Martin Tristani-Firouzi, Deepak Srivastava, Jonathan G Seidman, Christine E Seidman, Pediatric Cardiac Genomics Consortium
Publikováno v:
eLife, Vol 9 (2020)
Damaging GATA6 variants cause cardiac outflow tract defects, sometimes with pancreatic and diaphragmic malformations. To define molecular mechanisms for these diverse developmental defects, we studied transcriptional and epigenetic responses to GATA6
Externí odkaz:
https://doaj.org/article/de48ca73426c4e9e8cd88b2b87f1b9e5
Autor:
D L, Chan, V, Rodriguez-Freixinos, M, Doherty, K, Wasson, N, Iscoe, W, Raskin, J, Hallet, S, Myrehaug, C, Law, A, Thawer, K, Nguyen, S, Singh
Publikováno v:
European Journal of Cancer. 169:74-81
Higher grade neuroendocrine neoplasm (NENs) continues to pose a treatment dilemma, with the optimal treatment undefined. Although immunotherapy has revolutionised the treatment of many cancers, its role in NENs remains unclear. We aimed to investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190a5cc37c718de391f899fcd41df760
https://doi.org/10.1016/j.ejca.2022.03.029
https://doi.org/10.1016/j.ejca.2022.03.029
Autor:
Wei Shi, Angel P. Scialdone, James I. Emerson, Liu Mei, Lauren K. Wasson, Haley A. Davies, Christine E. Seidman, Jonathan G. Seidman, Jeanette G. Cook, Frank L. Conlon
Publikováno v:
Circulation Research.
Background: Left ventricular noncompaction (LVNC) is a prevalent cardiomyopathy associated with excessive trabeculation and thin compact myocardium. Patients with LVNC are vulnerable to cardiac dysfunction and at high risk of sudden death. Although s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3061e69b8487e17a439bdeae0865139
https://doi.org/10.1161/circresaha.122.322223
https://doi.org/10.1161/circresaha.122.322223
Akademický článek
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Autor:
Megan K. Wasson, Cassidy Whitson, Bridget Miller, Wondwossen Abebe, Belay Tessema, Lisa E. Emerson, Puneet Anantharam, Annisa Befekadu Tesfaye, Jessica K. Fairley
Publikováno v:
Frontiers in Tropical Diseases. 3
BackgroundDespite extensive control measures and a declining number of human reservoirs, the incidence of leprosy in excess of 200,000 new cases each year suggests that alternative pathways of transmission may play a role in continued endemicity. Par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bad9b3e9571392b80d2c934d5c6cb780
https://doi.org/10.3389/fitd.2022.934030
https://doi.org/10.3389/fitd.2022.934030
Autor:
Daniel Bernstein, Martin Tristani-Firouzi, Jane W. Newburger, Sarah U. Morton, Diane E. Dickel, Lauren K. Wasson, Seong Won Kim, Jonathan G. Seidman, Martina Brueckner, Hongjian Qi, Elizabeth Goldmuntz, George A. Porter, Eric E. Schadt, Olga G. Troyanskaya, Kathryn B. Manheimer, Jian Zhou, Jason Homsy, Michael Parfenov, Steven R. DePalma, Bruce D. Gelb, Andrew Farrell, Alexander Kitaygorodsky, Matt Velinder, Gabor T. Marth, Richard B. Kim, Nihir Patel, Jonathan R. Kaltman, Felix Richter, Deepak Srivastava, Kathleen M. Chen, Yufeng Shen, Joshua M. Gorham, Christine E. Seidman, Alessandro Giardini, Wendy K. Chung
Publikováno v:
Nature Genetics. 52:769-777
A genetic etiology is identified for one-third of patients with congenital heart disease (CHD), with 8% of cases attributable to coding de novo variants (DNVs). To assess the contribution of noncoding DNVs to CHD, we compared genome sequences from 74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f24be7160476aa52e32f103edff9347b
https://doi.org/10.1038/s41588-020-0652-z
https://doi.org/10.1038/s41588-020-0652-z
Autor:
Ileana M. Cristea, Frank L. Conlon, William T. Pu, Xinlei Sheng, Brynn N. Akerberg, Zachary L. Robbe, Lauren K. Wasson, Caralynn M. Wilczewski, Austin J. Hepperla, Ian J. Davis, Wei Shi
The Nucleosome Remodeling and Deacetylase (NuRD) complex is one of the central chromatin remolding complexes that mediate gene repression. NuRD is essential for numerous developmental events, including heart development. Clinical and genetic studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7b46e9a05d16f3c8a0cade9c809cfb2
https://doi.org/10.1101/2021.10.28.466285
https://doi.org/10.1101/2021.10.28.466285
Akademický článek
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