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Publikováno v:
Carcinogenesis. 17:501-506
The presence of N7-alkylguanine adducts in DNA was analysed in a group of 46 patients with larynx tumours. All patients were subjected to laryngectomy and the tissues accessible for analysis by (32)P-post-labelling assay were larynx tumour, larynx no
Publikováno v:
Mutation Research/Environmental Mutagenesis and Related Subjects. 313:269-276
32 P-Postlabelling was applied to study the distribution of adducts in white blood cells of foundry workers exposed to polycylic aromatic hydrocarbons. The distribution of the adducts among 63 workers followed an apparently trimodal pattern, which co
Publikováno v:
Chemico-Biological Interactions. 80:99-107
1, N 6 -ethenodeoxyadenosine-, 1, N 2 -ethenodeoxyguanosine- and 3, N 4 -ethenodeoxycytidine-3′-monophosphates were labeled by [γ- 32 P] ATP using T4 polynucleotide kinase in conditions commonly used for the 32 P-postlabeling assay. Kinetic studie
Publikováno v:
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 18(3)
Polycyclic aromatic hydrocarbons (PAH) are a well-characterized group of mutagens and carcinogens. Benzo(a)pyrene [B(a)P], the best known compound in the group, exerts its genotoxic activity following metabolic activation, when it acquires the proper
Publikováno v:
Journal of applied genetics. 42(2)
Arylamines are known bladder carcinogens deriving from tobacco smoke and environmental pollution. Arylamines are metabolised by NAT1 and NAT2 polymorphic enzymes in reactions of carcinogen activation and detoxification. We analysed genetic polymorphi
Publikováno v:
Otolaryngologia polska = The Polish otolaryngology. 55(5)
The results concerning examination of DNA adducts in oral (23 patients), pharyngeal (23 patients) and larynx cancer (10 patients) subjects are presented. DNA adduct levels were compared in respect to anatomical structure (primary tumour location), nu
[Paclitaxel (Taxol) in chemotherapy of head and neck cancer--just another proposal or breakthrough?]
Publikováno v:
Otolaryngologia polska = The Polish otolaryngology. 55(5)
The examples of so far application of taxol in head and neck cancer are not completely clear. This is the first representative of a totally new group of cytostatics known as taxones. Presently, paclitaxel (TAXOL) is the anti-cancer drug commonly used
Autor:
P, Dabrowski, K, Szyfter
Publikováno v:
Otolaryngologia polska = The Polish otolaryngology. 55(1)
The bleomycin test was established in the laboratory of Hsu et al. (M.D. Anderson Cancer Center, Houston, Texas) for quantitative estimation of hidden chromosome instability. The article presents a concept, method and applicability of the test. Chrom