Zobrazeno 1 - 10 of 483 pro vyhledávání: '"K, Siddle"'
1
Glycomics investigation into insulin action
Autor: James Scott, Dirk Hadaschik, Dominique Gauguier, Sylvia Richardson, Simon Parry, Christine Blancher, Howard R. Morris, Timothy J. Aitman, Anne Dell, Natalia Bochkina, Mande K. Kumaran, K. Siddle
Defects in glycosylation are becoming increasingly associated with a range of human diseases. In some cases, the disease is caused by the glycosylation defect, whereas in others, the aberrant glycosylation may be a consequence of the disease. The imp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1904bd76c687880c1bdde91ffc6b0b4b
https://ora.ox.ac.uk/objects/uuid:f486b51c-62f5-423f-a3e2-da7798ef4dec
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2
Can we prevent postnatal depression? A randomized controlled trial to assess the effect of continuity of midwifery care on rates of postnatal depression in high-risk women
Autor: M. N. Marks, K. Siddle, C. Warwick
Publikováno v: The Journal of Maternal-Fetal & Neonatal Medicine. 13:119-127
To evaluate the effectiveness of continuous midwifery care in reducing rates of postnatal depression in women with histories of depression.Fifty-one women from a sample of 98 pregnant women with histories of major depressive disorder were randomly al
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0699d373c61ab188e0c8b9b800cb34f
https://doi.org/10.1080/jmf.13.2.119.127
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3
Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors
Autor: Kathy H. Surinya, K. Siddle, Diane L. Cope, L. Molina, Maria A. Soos, C. A. Niesler, Birgitte Ursø
Publikováno v: Biochemical Society Transactions. 29:513-525
The physiological roles of insulin and insulin-like growth factors (IGFs) are distinct, with insulin acting to regulate cellular uptake and metabolism of fuels, whereas IGFs promote cell growth, survival and differentiation. The only components of si
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfa409775af659fbfc92b0a2ef6f5ea
https://doi.org/10.1042/bst0290513
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4
Structural domains of the insulin receptor and IGF receptor required for dimerisation and ligand binding
Autor: K. Siddle, Cristina Marino-Buslje, L Molina, D.R Quinn
Publikováno v: FEBS Letters. 467:226-230
We investigated structural requirements for dimerisation and ligand binding of insulin/IGF receptors. Soluble receptor fragments consisting of N-terminal domains (L1/CYS/L2, L1/CYS/L2/F0) or fibronectin domains (F0/F1/F2, F1/F2) were expressed in CHO
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3d0f46c4699cc872077b4633ad0fa3
https://doi.org/10.1016/s0014-5793(00)01161-3
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6
Insulin-like growth factors in human breast cancer
Autor: Matthew J. Ellis, Marian Taylor, John Hanfelt, Maura E. Redington, K. Siddle, Sara B. Jenkins, Adrian L. Harris, R Leek
Publikováno v: Breast Cancer Research and Treatment. 52:175-184
IGF1 and IGF2 are circulating peptide hormones and locally-acting growth factors with both paracrine and autocrine functions. IGF1 and IGF2 signal through a common tyrosine kinase receptor, the insulin-like growth factor 1 receptor (IGF1R), and have
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d0386329a7d2a9c25b1839162c3ca2
https://doi.org/10.1023/a:1006127621512
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7
The carboxyl-terminal domain of insulin-like growth factor-I receptor interacts with the insulin receptor and activates its protein tyrosine kinase
Autor: Amanda C. Hayward, Shu-Lian Li, Anatolii P. Koval, Yehiel Zick, John Termini, Yoko Fujita-Yamaguchi, K. Siddle, Derek LeRoith
Publikováno v: FEBS Letters. 421:45-49
Receptors for insulin and insulin-like growth factor-I (IR and IGFIR) consisting of the alpha2beta2 structure are protein tyrosine kinases (PTKs). Carboxyl-terminal (CT) domains of their beta subunits are structurally diverse while the PTK domains sh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef81b0bfa0675643c9c55864b57ce8b4
https://doi.org/10.1016/s0014-5793(97)01523-8
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10
Is stimulation of class-I phosphatidylinositol 3-kinase activity by insulin sufficient to activate pathways involved in glucose metabolism
Autor: B. T. Navé, K. Siddle, Peter R. Shepherd
Publikováno v: Biochemical Society Transactions. 25:978-981
In summary, it is still unclear which type of PI 3-kinase is involved in the activation of glycogen synthase. However, there is a strong body of evidence to suggest class-1 PI 3-kinase activity is necessary for insulin stimulation of glucose transpor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::513a5b05bfb2d684426e5961422e141f
https://doi.org/10.1042/bst0250978
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