A common intracellular allosteric binding site for antagonists of the CXCR2 receptor

Autor: ME Bond, Neil John Press, Michelle Bradley, K Salchow, Peter Hunt, Steven J. Charlton, SC Evans

Publikováno v: British Journal of Pharmacology. 159:1429-1439

Background and purpose: We have previously shown that SB265610 (1-(2-bromo-phenyl)-3-(7-cyano-3H-benzotriazol-4-yl)-urea) behaves as an allosteric, inverse agonist at the C-X-C chemokine (CXCR)2 receptor. The aim of this study was to determine whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d4f4fe0cc48770792ff67af3f23553f
https://doi.org/10.1111/j.1476-5381.2009.00623.x

A common intracellular allosteric binding site for antagonists of the CXCR2 receptor

Autor: K, Salchow, M E, Bond, S C, Evans, N J, Press, S J, Charlton, P A, Hunt, M E, Bradley

Publikováno v: British journal of pharmacology. 159(7)

We have previously shown that SB265610 (1-(2-bromo-phenyl)-3-(7-cyano-3H-benzotriazol-4-yl)-urea) behaves as an allosteric, inverse agonist at the C-X-C chemokine (CXCR)2 receptor. The aim of this study was to determine whether SB265610, in addition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::700376459ac09c87f67748da844038d2
https://pubmed.ncbi.nlm.nih.gov/20233217

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Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.

Autor: Baker JG; School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom., Adams LA, Salchow K, Mistry SN, Middleton RJ, Hill SJ, Kellam B

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2011 Oct 13; Vol. 54 (19), pp. 6874-87. Date of Electronic Publication: 2011 Sep 16.