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Akademický článek

Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans

Autor: Ricardo Laranjeiro, Girish Harinath, Amelia K. Pollard, Christopher J. Gaffney, Colleen S. Deane, Siva A. Vanapalli, Timothy Etheridge, Nathaniel J. Szewczyk, Monica Driscoll

Publikováno v: iScience, Vol 24, Iss 2, Pp 102105- (2021)

Summary: Extended space travel is a goal of government space agencies and private companies. However, spaceflight poses risks to human health, and the effects on the nervous system have to be better characterized. Here, we exploited the unique experi

Externí odkaz: https://doaj.org/article/1df436c7357b41f8b8579e093ea9f90b

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Dissecting the Kinetic Mechanism of Human Lysine Methyltransferase 2D and Its Interactions with the WRAD2 Complex

Autor: Lucy V. Edwardes, Sarah J. Caswell, Mariacarmela Giurrandino, Xiang Zhai, Andrea Gohlke, Demetrios H. Kostomiris, Hannah K. Pollard, Alexander Pflug, Gregory R. Hamm, Kate V. Jervis, Paul N. Clarkson, Karl Syson

Publikováno v: Biochemistry. 61:1974-1987

Human lysine methyltransferase 2D (hKMT2D) is an epigenetic writer catalyzing the methylation of histone 3 lysine 4. hKMT2D by itself has little catalytic activity and reaches full activation as part of the WRAD2 complex, additionally comprising bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4381a5f29cee7d23fa10c29cca9377de
https://doi.org/10.1021/acs.biochem.2c00385

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Akademický článek

Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of Caenorhabditis elegans and its functional response to drugs

Autor: Jennifer E. Hewitt, Amelia K. Pollard, Leila Lesanpezeshki, Colleen S. Deane, Christopher J. Gaffney, Timothy Etheridge, Nathaniel J. Szewczyk, Siva A. Vanapalli

Publikováno v: Disease Models & Mechanisms, Vol 11, Iss 12 (2018)

Muscle strength is a key clinical parameter used to monitor the progression of human muscular dystrophies, including Duchenne and Becker muscular dystrophies. Although Caenorhabditis elegans is an established genetic model for studying the mechanisms

Externí odkaz: https://doaj.org/article/61baf423958a4552b9c20b2a837bd5da

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Supplementary Materials and Methods, Supplementary Figures 1 through 8, and Supplementary Tables 1 through 6 from Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis

Supplementary methods. Figure S1. (related to Fig. 1A-F) Analysis of mutations of MLK4 and MLK1 present in CRC cells. Figure S2 (related to Fig. 2 and 3) Structural analysis of MLK4 mutants. Figure S3 (related to Fig. 2 and 3) Structural analysis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0722c76c95b7bbc4901db1e2b3ae68
https://doi.org/10.1158/0008-5472.22409912

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Akademický článek

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Akademický článek

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3D Culture Model to Characterize RSV Infection in the Peripheral Nervous System

Autor: S. Medearis, R. Brown, K. Pollard, A. Bosak, C. Dugas, A. Das, R. Sato, V. Traina-Dorge, M. Moore, G. Piedimonte

Publikováno v: B56. WHAT'S UP IN THE PNEUMONIA WORLD?.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49b4be66a4270e6d14ad0bcfeec0e3e6
https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3126

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Dose adjustments of Elexacaftor/Tezacaftor/Ivacaftor in response to mental health side effects in adults with cystic fibrosis

Autor: G. Spoletini, L. Gillgrass, K. Pollard, N. Shaw, E. Williams, C. Etherington, I.J. Clifton, D.G. Peckham

Publikováno v: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 21(6)

Deterioration in mental health has been reported in a minority of individuals with cystic fibrosis starting elexacafor/tezacaftor/ivacaftor (ELX/TEZ/IVA). We report our experience of using sweat chloride and markers of clinical stability to titrate d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36a18b9987f0d0b4d2c4abcc19800dc
https://pubmed.ncbi.nlm.nih.gov/35585012

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Impatiens glandulifera (Himalayan balsam)

Autor: K Pollard

Publikováno v: CABI Compendium.

This datasheet on Impatiens glandulifera covers Identity, Overview, Distribution, Dispersal, Hosts/Species Affected, Diagnosis, Biology & Ecology, Environmental Requirements, Natural Enemies, Impacts, Uses, Prevention/Control, Further Information.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c0f1ef0e6d22d77cd6bf33f14a86c2d
https://doi.org/10.1079/cabicompendium.28766

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