Zobrazeno 1 - 10
of 6 046
pro vyhledávání: '"K, Noguchi"'
Autor:
Allen Yen, Simona Sarafinovska, Xuhua Chen, Dominic D. Skinner, Fatjon Leti, MariaLynn Crosby, Jessica Hoisington-Lopez, Yizhe Wu, Jiayang Chen, Zipeng A. Li, Kevin K. Noguchi, Robi D. Mitra, Joseph D. Dougherty
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Mutations reducing the function of MYT1L, a neuron-specific transcription factor, are associated with a syndromic neurodevelopmental disorder. MYT1L is used as a pro-neural factor in fibroblast-to-neuron transdifferentiation and is hypothesi
Externí odkaz:
https://doaj.org/article/641f235149614360b9fe7de9d43b9ff1
Autor:
Diana C. Beard, Xiyun Zhang, Dennis Y. Wu, Jenna R. Martin, Alyssa Erickson, Jane Valeriane Boua, Nicole Hamagami, Raylynn G. Swift, Katherine B. McCullough, Xia Ge, Austin Bell-Hensley, Hongjun Zheng, Cory W. Palmer, Nicole A. Fuhler, Austin B. Lawrence, Cheryl A. Hill, Thomas Papouin, Kevin K. Noguchi, Audrey McAlinden, Joel R. Garbow, Joseph D. Dougherty, Susan E. Maloney, Harrison W. Gabel
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113411- (2023)
Summary: Phenotypic heterogeneity in monogenic neurodevelopmental disorders can arise from differential severity of variants underlying disease, but how distinct alleles drive variable disease presentation is not well understood. Here, we investigate
Externí odkaz:
https://doaj.org/article/48fc308841a24ec68b568d4410c3c83e
Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus.
Autor:
Jenna R Rosinski, Lauren E Raasch, Patrick Barros Tiburcio, Meghan E Breitbach, Phoenix M Shepherd, Keisuke Yamamoto, Elaina Razo, Nicholas P Krabbe, Mason I Bliss, Alexander D Richardson, Morgan A Einwalter, Andrea M Weiler, Emily L Sneed, Kerri B Fuchs, Xiankun Zeng, Kevin K Noguchi, Terry K Morgan, Alexandra J Alberts, Kathleen M Antony, Sabrina Kabakov, Karla K Ausderau, Ellie K Bohm, Julia C Pritchard, Rachel V Spanton, James N Ver Hoove, Charlene B Y Kim, T Michael Nork, Alex W Katz, Carol A Rasmussen, Amy Hartman, Andres Mejia, Puja Basu, Heather A Simmons, Jens C Eickhoff, Thomas C Friedrich, Matthew T Aliota, Emma L Mohr, Dawn M Dudley, David H O'Connor, Christina M Newman
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011282 (2023)
In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about the impacts of gestational African-lineage ZIKV infec
Externí odkaz:
https://doaj.org/article/9603e93a993b481b9b1de7a38cf4ca26
Autor:
Chrysanthy Ikonomidou, Sophie H. Wang, Nicole A. Fuhler, Shreya Larson, Saverio Capuano, III, Kevin R. Brunner, Kristin Crosno, Heather A. Simmons, Andres F. Mejia, Kevin K. Noguchi
Publikováno v:
Neurobiology of Disease, Vol 171, Iss , Pp 105814- (2022)
Barbiturates and benzodiazepines are GABAA-receptor agonists and potent antiseizure medications. We reported that exposure of neonatal macaques to combination of phenobarbital and midazolam (Pb/M) for 24 h, at clinically relevant doses and plasma lev
Externí odkaz:
https://doaj.org/article/0b33585d32a84a88b6448d72e5c685f0
Autor:
Lauren E Raasch, Keisuke Yamamoto, Christina M Newman, Jenna R Rosinski, Phoenix M Shepherd, Elaina Razo, Chelsea M Crooks, Mason I Bliss, Meghan E Breitbach, Emily L Sneed, Andrea M Weiler, Xiankun Zeng, Kevin K Noguchi, Terry K Morgan, Nicole A Fuhler, Ellie K Bohm, Alexandra J Alberts, Samantha J Havlicek, Sabrina Kabakov, Ann M Mitzey, Kathleen M Antony, Karla K Ausderau, Andres Mejia, Puja Basu, Heather A Simmons, Jens C Eickhoff, Matthew T Aliota, Emma L Mohr, Thomas C Friedrich, Thaddeus G Golos, David H O'Connor, Dawn M Dudley
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010623 (2022)
Countermeasures against Zika virus (ZIKV), including vaccines, are frequently tested in nonhuman primates (NHP). Macaque models are important for understanding how ZIKV infections impact human pregnancy due to similarities in placental development. T
Externí odkaz:
https://doaj.org/article/b739a79111ea407d95e30de3bce37b4a
Autor:
Ivan M. Rosado-Mendez, Kevin K. Noguchi, Laura Castañeda-Martinez, George Kirvassilis, Sophie H. Wang, Francesca Manzella, Brant S. Swiney, Kobe Masuoka, Saverio Capuano, III, Kevin G. Brunner, Kristin Crosno, Quinton W. Guerrero, Hayley Whitson, Ansgar Brambrink, Heather S. Simmons, Andres F. Mejia, James A. Zagzebski, Timothy J. Hall, Chrysanthy Ikonomidou
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 554-562 (2019)
Apoptosis is triggered in the developing mammalian brain by sedative, anesthetic or antiepileptic drugs during late gestation and early life. Whether human children are vulnerable to this toxicity mechanism remains unknown, as there are no imaging te
Externí odkaz:
https://doaj.org/article/f86792d81f6c469ab5499c822c67f712
Autor:
Kevin K. Noguchi, Nicole A. Fuhler, Sophie H. Wang, Saverio Capuano, III, Kevin R. Brunner, Shreya Larson, Kristin Crosno, Heather A. Simmons, Andres F. Mejia, Lauren D. Martin, Gregory A. Dissen, Ansgar Brambrink, Chrysanthy Ikonomidou
Publikováno v:
Neurobiology of Disease, Vol 149, Iss , Pp 105245- (2021)
Barbiturates and benzodiazepines are potent GABAA receptor agonists and strong anticonvulsants. In the developing brain they can cause neuronal and oligodendroglia apoptosis, impair synaptogenesis, inhibit neurogenesis and trigger long-term neurocogn
Externí odkaz:
https://doaj.org/article/27ba63a8d3634d8a83747ee45c334675
Autor:
Larry D. Spears, Sangeeta Adak, Guifang Dong, Xiaochao Wei, George Spyropoulos, Qiang Zhang, Li Yin, Chu Feng, Donghua Hu, Irfan J. Lodhi, Fong-Fu Hsu, Rithwick Rajagopal, Kevin K. Noguchi, Carmen M. Halabi, Lindsey Brier, Annie R. Bice, Brian V. Lananna, Erik S. Musiek, Oshri Avraham, Valeria Cavalli, Jerrah K. Holth, David M. Holtzman, David F. Wozniak, Joseph P. Culver, Clay F. Semenkovich
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100079- (2021)
Vascular disease contributes to neurodegeneration, which is associated with decreased blood pressure in older humans. Plasmalogens, ether phospholipids produced by peroxisomes, are decreased in Alzheimer's disease, Parkinson's disease, and other neur
Externí odkaz:
https://doaj.org/article/a4a46b80f32646ea94b6e4c85fe531fe
Autor:
T. O. Sato, T. M. Sato, H. Sagawa, K. Noguchi, N. Saitoh, H. Irie, K. Kita, M. E. Mahani, K. Zettsu, R. Imasu, S. Hayashida, Y. Kasai
Publikováno v:
Atmospheric Measurement Techniques, Vol 11, Pp 1653-1668 (2018)
We performed a feasibility study of constraining the vertical profile of the tropospheric ozone by using a synergetic retrieval method on multiple spectra, i.e., ultraviolet (UV), thermal infrared (TIR), and microwave (MW) ranges, measured from sp
Externí odkaz:
https://doaj.org/article/8561740e716b418e844fca477a43feb5
Autor:
Chrysanthy Ikonomidou, George Kirvassilis, Brant S. Swiney, Sophie H. Wang, Jacob N. Huffman, Sasha L. Williams, Kobe Masuoka, Saverio Capuano, III, Kevin R. Brunner, Kristin Crosno, Heather S. Simmons, Andres F. Mejia, Christopher A. Turski, Ansgar Brambrink, Kevin K. Noguchi
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104489- (2019)
Sedatives and anesthetics can injure the developing brain. They cause apoptosis of neurons and oligodendrocytes, impair synaptic plasticity, inhibit neurogenesis and trigger long-term neurocognitive deficits. The projected vulnerable period in humans
Externí odkaz:
https://doaj.org/article/eb953d7fb22749b1bfc7e244b98ecfdf