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Multiple serotonin mechanisms in animal models of anxiety

Autor: M.A.E. Critchley, J.W. McBlane, K. Njung'e, Sheila L. Handley

Publikováno v: Behavioural Brain Research. 58:203-210

Responses to serotonergic drugs in animal models of ‘anxiety’ are reviewed with emphasis on the elevated X-maze. Evidence for the ‘classic’ hypothesis, that decreasing serotonergic function is anxiolytic and increasing it anxiogenic, is most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31fc354c313f197547875514a6c4665a
https://doi.org/10.1016/0166-4328(93)90104-x

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Analgesic and antipyretic effects of Myrica salicifolia (Myricaceae)

Autor: K. Njung'e, J. W. Mwangi, K.A.M Kuria, G Muriuki

Publikováno v: Phytotherapy research : PTR. 16

Myrica salicifolia Hoechst (Myricaceae) root extract was found to have analgesic activity in mice. In rats there was antipyretic but no antiinflammatory activity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64bf79caeb20184b356e6b13ddddf31f
https://pubmed.ncbi.nlm.nih.gov/11933145

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Multiple serotonin mechanisms in animal models of anxiety: environmental, emotional and cognitive factors

Autor: S L, Handley, J W, McBlane, M A, Critchley, K, Njung'e

Publikováno v: Behavioural brain research. 58(1-2)

Responses to serotonergic drugs in animal models of 'anxiety' are reviewed with emphasis on the elevated X-maze. Evidence for the 'classic' hypothesis, that decreasing serotonergic function is anxiolytic and increasing it anxiogenic, is most consiste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2efa7780cb18146cac7adcddd7c38592
https://pubmed.ncbi.nlm.nih.gov/8136047

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Actions and some interactions of 5-HT1A ligands in the elevated X-maze and effects of dorsal raphe lesions

Autor: M. A. E. Critchley, Sheila L. Handley, K. Njung'e

Publikováno v: Psychopharmacology. 106(4)

Effects of 5-HT1A agonists and partial agonists on open/total arm entry ratio (OTR) have been examined in the elevated X-maze anxiety model. 8-OH-DPAT (0.05-0.2 mg/kg), RU 24969 (0.5-2.0 mg/kg) and BAY R 1521 (0.1-1.2 mg/kg) produced dose-dependent r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b41d7409756df85d1f50ed2bcb64883
https://pubmed.ncbi.nlm.nih.gov/1533721

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Effects of 5-HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; a putative test for anxiolytic agents

Autor: K. Njung'e, Sheila L. Handley

1. The effects of 5-hydroxytryptamine (5-HT) uptake inhibitors, agonists and antagonists have been evaluated on mouse marble-burying behaviour, a putative test for anxiolytic agents. The high levels of locomotor activity occurring on first exposure t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a03020f9b0603d33ccc04e6508ce73
https://europepmc.org/articles/PMC1908295/

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Molluscicidal activity of Solanum aculeatum (family: Solanaceae) berries against Biomphalaria pfeifferi, Bulinus globosus and Lymnaea natalensis

Autor: G M, Mkoji, K, Njung'e, G, Kimani, W, Kofi-Tsekpo, B N, Mungai, T, Kamau, C, Muthaura, R M, Kibaya, E, Wambayi

Publikováno v: Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ). 40(2)

Aqueous suspensions of powder of sun- or freeze-dried berries of the plant Solanum aculeatum (Family Solanaceae), indigenous in Kenya, were tested for molluscicidal activity against Biomphalaria pfeifferi, Bulinus globosus and Lymnaea natalensis unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be3d08f8eb4b84c1930d27beae10c1f7
https://pubmed.ncbi.nlm.nih.gov/2772517

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