Cellular origin and clonal evolution of human dedifferentiated liposarcoma

Autor: Nadège Gruel, Chloé Quignot, Laëtitia Lesage, Sophie El Zein, Sylvie Bonvalot, Dimitri Tzanis, Khadija Ait Rais, Fabien Quinquis, Bastien Manciot, Julien Vibert, Nadine El Tannir, Ahmed Dahmani, Héloïse Derrien, Didier Decaudin, Ivan Bièche, Laura Courtois, Odette Mariani, Laëtitia K. Linares, Laurie Gayte, Sylvain Baulande, Joshua J. Waterfall, Olivier Delattre, Gaëlle Pierron, Sarah Watson

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Dedifferentiated liposarcoma (DDLPS) is the most frequent high-grade soft tissue sarcoma subtype. It is characterized by a component of undifferentiated tumor cells coexisting with a component of well-differentiated adipocytic tumor cells. B

Externí odkaz: https://doaj.org/article/9071f50c747241d985e7d638e844b164

Supplementary Table S6 from Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

Autor: Jean-Emmanuel Sarry, Christian Récher, Martin Carroll, Gwenn Danet-Desnoyers, Mary Selak, François Vergez, Jean-Charles Portais, Barbara H. Garmy-Susini, François Delhommeau, Lara Gales, Tony Palama, Pierre Hirsch, Yara Barreira, Olivier Duchamp, Yves Collette, Emmanuel Griessinger, Rémy Castellano, Camille Montersino, Laetitia K. Linares, Jason Iacovoni, Laurent Vallar, Tony Kaoma, Suzanne Tavitian, Audrey Sarry, Nizar Serhan, Marion David, Nicolas Broin, Stéphanie Cassant-Sourdy, Marie-Laure Nicolau-Travers, Virginie Féliu, Héléna Boutzen, Clément Larrue, Sarah Scotland, Marine Fraisse, Lucille Stuani, Mayumi Sugita, Claudie Bosc, Robin Perry, Mohsen Hosseini, Nesrine Aroua, Fabienne de Toni, Estelle Saland, Thomas Farge

HIGH CD36 gene signature generated from upregulated genes in AML patients that express the most CD36 mRNA compared to that of the lowest expression of CD36 in TCGA cohort.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4551720b39c2c7a62933d1c7a214327a
https://doi.org/10.1158/2159-8290.22532159

RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53

Autor: Vincent Cavaillès, Sandrine Bonnet, Laetitia K. Linares, Catherine Teyssier, Valentin Jacquier, Delphine Gitenay, Balazs Gyorffy, Samuel Fritsch, Stéphan Jalaguier

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2022, 79 (5), pp.270. ⟨10.1007/s00018-022-04277-3⟩

Cancer cells with uncontrolled proliferation preferentially depend on glycolysis to grow, even in the presence of oxygen. Cancer cell proliferation is sustained by the production of glycolytic intermediates, which are diverted into the pentose phosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa8d8653cda888cef6850f9531c1ecb
https://hal.umontpellier.fr/hal-03858446/file/s00018-022-04277-3.pdf

Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia

Autor: Lara Gales, Camille Montersino, Marc Conti, Pierre Bories, Courtney D. DiNardo, Brandon Nicolay, Fabien Jourdan, Nicolas Broin, Mohsen Hosseini, Guillaume Cognet, Yves Gibon, Marie Sabatier, Tony Kaoma, Marina Konopleva, Lucille Stuani, Mathilde Gotanègre, Christian Recher, Laurent Fernando, Vera Pancaldi, Nathalie Poupin, Estelle Saland, Jean-Emmanuel Sarry, Joseph R. Marszalek, Andrei Turtoi, Thomas Farge, Feng Wang, Yves Collette, Laurent Le Cam, Madi Y. Cissé, Cédric Cassan, Alexis Hucteau, Claudie Bosc, Natalia Baran, Sebastien Ronseaux, Aliki Zavoriti, François Fenaille, Florence Castelli, Laetitia K. Linares, Evgenia Turtoi, Emeline Chu-Van, Martin Carroll, Pierre-Luc Mouchel, Mary A. Selak, Guillaume Cazals, Emeline Boet, Rémy Castellano, Floriant Bellvert, Norbert Vey, Clément Larrue, Koichi Takahashi, Ambrine Sahal, Sylvain Loric, Jean-Charles Portais

Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, 2021, 218 (5), pp.e20200924. ⟨10.1084/jem.20200924⟩
Journal of Experimental Medicine, Rockefeller University Press, 2021, 218 (5), ⟨10.1084/jem.20200924⟩
The Journal of Experimental Medicine

Stuani et al. demonstrate that IDH mutant AML cells display an enhanced mitochondrial phenotype, which is not reversed by IDH mutant inhibitors. This study provides a scientific rationale for combinatory mitochondrial-targeted therapies to treat IDH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfb2b30f8b948c067d643d1119fbb0e
https://amu.hal.science/hal-03563454/file/jStuani_em_20200924.pdf

Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma

Autor: Marie-Christine Chateau, Laurent Le Cam, Giuseppe Arena, Nelly Firmin, Jean-Charles Portais, Madi Y. Cissé, Laurie Gayte, Aurélie Maran-Gonzalez, Laetitia K. Linares, Hélène Delpech, Frédéric Chibon, Romain Riscal, Floriant Bellvert, Maryse Fuentes, Sophie Le Gellec, Charles Theillet, Maud Heuillet, Samuel Pyrdziak, S. Carrere

Publikováno v: Science Translational Medicine
Science Translational Medicine, 2020, 12 (547), ⟨10.1126/scitranslmed.aay2163⟩
Science Translational Medicine, American Association for the Advancement of Science, 2020, 12 (547), ⟨10.1126/scitranslmed.aay2163⟩

International audience; Well-differentiated and dedifferentiated liposarcomas (LPSs) are characterized by a systematic amplification of the MDM2 oncogene, which encodes a key negative regulator of the p53 pathway. The molecular mechanisms underlying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00954e05cd789186170d9dc82fef6c71
https://hal.inrae.fr/hal-03436075