Zobrazeno 1 - 10
of 79
pro vyhledávání: '"K, Lertratanangkoon"'
Publikováno v:
Cancer research. 56(5)
Dietary deficiency of methionine (Met) is known to deplete cellular Met and cause DNA hypomethylation, but depletion of Met and impairment in methylation due to chemically induced glutathione (GSH) depletion has escaped recognition. In this study, th
Autor:
K. Lertratanangkoon, J.M. Scimeca
Publikováno v:
Toxicology and applied pharmacology. 122(2)
Bromobenzene (800 mg/kg, ip) caused severe liver necrosis with massive hemorrhage in the golden Syrian hamster within the first 24 hr. Kidney injury was also observed. Treatment with N-acetylmethionine (NAM) at an ip dose of 1200 mg/kg at 5 hr after
Publikováno v:
Research communications in chemical pathology and pharmacology. 80(3)
Bromobenzene is metabolized by the rat and guinea pig to 2-, 3- and 4-bromophenol. 3-Bromophenol is formed through the sulfur-series pathway to phenols. This route involves the enterohepatic circulation; the key intermediate is the S-(2-hydroxy-4-bro
Autor:
J. Nowlin, K. Lertratanangkoon, Carla M. Butler, Hill Rm, Kathleen Sommer, Marjorie G. Horning
Publikováno v:
Clinical Chemistry. 21:1282-1287
Gas chromatograph/mass spectrometer/computer systems can be used to quantify a wide variety of compounds of clinical interest. A quadrupole instrument operated in the chemical ionization (Cl) mode was used in these studies. Because of the sensitivity
Publikováno v:
Journal of Chromatography A. 399:303-319
Methods are described for the isolation and identification of three classes of bivalent sulfur metabolites characterized as neutral methylthio ethers, ethyl acetate-soluble acidic thioethers and ethyl acetate-insoluble acidic thioethers from rat and
Publikováno v:
Journal of Chromatography A. 399:321-339
Our studies of bromobenzene metabolism have shown that the 3,4-oxide is metabolized to 3- and 4-bromophenol through an extended glutathione pathway. The mechanism of sulfur elimination from a dihydrobromobenzene metabolite is not known, although it i
Autor:
Hill Rm, J. Nowlin, K. Lertratanangkoon, W.G. Stillwell, Marjorie G. Horning, P. A. Gregory, M. Stafford, Carla M. Butler
Publikováno v:
Clinical Chemistry. 20:282-287
Simple rapid procedures based on salt-solvent pairs have been developed for the isolation of drugs and drug metabolites from urine, plasma, and breast milk. The best overall recovery of drugs (84-104%) was obtained by using ammonium carbonate—ethyl
Autor:
M.G. Horning, K. Lertratanangkoon
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 181:59-65
A procedure for the separation and isolation of the urinary metabolites of carbamazepine by reversed-phase high-performance liquid chromatography is described. After extraction from urine, the metabolites were separated on either an analytical or sem
Publikováno v:
Clinical Chemistry. 23:157-164
We measured the concentrations of phenobarbital, phenytoin, primidone, ethosuximide, antipyrine, and caffeine in paired samples of saliva and plasma by gas chromatograph-mass spectrometer-computer (GC/MS/COM) and enzyme immunoassay. Mixed saliva was
Autor:
R. N. Stillwell, W.G. Stillwell, J. Nowlin, K. Lertratanangkoon, T. E. Zion, P. Kellaway, Marjorie G. Horning, Hill Rm
Publikováno v:
Journal of Chromatographic Science. 12:630-635