A glomerular transcriptomic landscape of apolipoprotein L1 in Black patients with focal segmental glomerulosclerosis

Autor: Michelle T. McNulty, Damian Fermin, Felix Eichinger, Dongkeun Jang, Matthias Kretzler, Noël P. Burtt, Martin R. Pollak, Jason Flannick, Astrid Weins, David J. Friedman, Matthew G. Sampson, K. Dell, J. Sedor, M. Schachere, J. Negrey, K. Lemley, B. Silesky, T. Srivastava, A. Garrett, C. Sethna, K. Laurent, P. Canetta, A. Pradhan, L. Greenbaum, C. Wang, C. Kang, S. Adler, J. LaPage, A. Athavale, M. Itteera, M. Atkinson, T. Dell, F. Fervenza, M. Hogan, J. Lieske, V. Chernitskiy, F. Kaskel, M. Ross, P. Flynn, J. Kopp, J. Blake, H. Trachtman, O. Zhdanova, F. Modersitzki, S. Vento, R. Lafayette, K. Mehta, C. Gadegbeku, S. Quinn-Boyle, M. Hladunewich, H. Reich, P. Ling, M. Romano, A. Fornoni, C. Bidot, M. Kretzler, D. Gipson, A. Williams, C. Klida, V. Derebail, K. Gibson, E. Cole, J. Ormond-Foster, L. Holzman, K. Meyers, K. Kallem, A. Swenson, K. Sambandam, Z. Wang, M. Rogers, A. Jefferson, S. Hingorani, K. Tuttle, M. Bray, E. Pao, A. Cooper, J.J. Lin, Stefanie Baker, L. Barisoni, J. Bixler, H. Desmond, S. Eddy, D. Fermin, B. Gillespie, V. Kurtz, M. Larkina, S. Li, C.C. Lienczewski, J. Liu, T. Mainieri, L. Mariani, M. Sampson, A. Smith, J. Zee, Carmen Avila-Casado, Serena Bagnasco, Joseph Gaut, Stephen Hewitt, Jeff Hodgin, Kevin Lemley, Laura Mariani, Matthew Palmer, Avi Rosenberg, Virginie Royal, David Thomas, Jarcy Zee, Laura Barisoni, Cynthia Nast

Publikováno v: Kidney International. 102:136-148

Apolipoprotein L1 (APOL1)-associated focal segmental glomerulosclerosis (FSGS) is the dominant form of FSGS in Black individuals. There are no targeted therapies for this condition, in part because the molecular mechanisms underlying APOL1's pathogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410b2f2c81813ed88f9d93dca5d87fd0
https://doi.org/10.1016/j.kint.2021.10.041

Quantification of Glomerular Structural Lesions: Associations With Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome

Autor: Jeffrey B. Hodgin, Laura H. Mariani, Jarcy Zee, Qian Liu, Abigail R. Smith, Sean Eddy, John Hartman, Habib Hamidi, Joseph P. Gaut, Matthew B. Palmer, Cynthia C. Nast, Anthony Chang, Stephen Hewitt, Brenda W. Gillespie, Matthias Kretzler, Lawrence B. Holzman, Laura Barisoni, K. Dell, J. Sedor, M. Schachere, J. Negrey, K. Lemley, E. Lim, T. Srivastava, A. Garrett, C. Sethna, K. Laurent, P. Canetta, A. Pradhan, L. Greenbaum, C. Wang, C. Kang, S. Adler, J. LaPage, A. Athavale, M. Itteera, M. Atkinson, S. Boynton, F. Fervenza, M. Hogan, J. Lieske, V. Chernitskiy, F. Kaskel, M. Ross, P. Flynn, J. Kopp, J. Blake, H. Trachtman, O. Zhdanova, F. Modersitzki, S. Vento, M. Bray, M. Kelton, A. Cooper, R. Lafayette, K. Mehta, C. Gadegbeku, S. Quinn-Boyle, M. Hladunewich, H. Reich, P. Ling, M. Romano, A. Fornoni, C. Bidot, M. Kretzler, D. Gipson, A. Williams, J. LaVigne, V. Derebail, K. Gibson, E. Cole, J. Ormond-Foster, L. Holzman, K. Meyers, K. Kallem, A. Swenson, K. Sambandam, Z. Wang, M. Rogers, A. Jefferson, S. Hingorani, K. Tuttle, J.J. Lin, L. Barisoni, J. Bixler, H. Desmond, S. Eddy, D. Fermin, B. Gillespie, V. Kurtz, M. Larkina, J. Lavigne, S. Li, C.C. Lienczewski, J. Liu, T. Mainieri, L. Mariani, M. Sampson, A. Smith, J. Zee, Carmen Avila-Casado, Serena Bagnasco, Joseph Gaut, Jeff Hodgin, Kevin Lemley, Laura Mariani, Matthew Palmer, Avi Rosenberg, Virginie Royal, David Thomas, Cynthia Nast

Publikováno v: American Journal of Kidney Diseases. 79:807-819.e1

Rationale & Objective The current classification system for focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) does not fully capture the complex structural changes in kidney biopsies, nor the clinical and molecular heterogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9a1f998ea34bfc0c0d1b0ae40e9297
https://doi.org/10.1053/j.ajkd.2021.10.004

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Practicing Critical Oral History : Connecting School and Community

Autor: Christine K. Lemley

Practicing Critical Oral History: Connecting School and Community provides ways and words for educators to use critical oral history in their classroom and communities in order to put their students and the voices of people from marginalized communit