Výsledky vyhledávání - "K, Kaushansky"

Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice

Autor: L. Laterveer, W. E. Fibbe, J.F.M. Pruijt, D. Foster, D. P. M. Heemskerk, R. Willemze, K Kaushansky

Publikováno v: Blood. 86:3308-3313

The recent cloning of the ligand of the c-Mpl hematopoietin receptor has indicated a major role for this cytokine in the development of megakaryocytes. In this study we have applied c-Mpl ligand (thrombopoietin [TPO]) in the setting of syngeneic tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::385a0923f3e1f9d3e2df831db4e89114
https://doi.org/10.1182/blood.v86.9.3308.bloodjournal8693308

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Coordinate regulation of multiple human lymphokine genes by Oct-1 and potentially novel 45 and 43 kDa polypeptides

Autor: K Kaushansky, S G Shoemaker, C A O'Rork, J M McCarty

Publikováno v: The Journal of Immunology. 152:1812-1820

The hematologic response to inflammation is critically dependent on the release of a family of glycoproteins termed CSFs. Central to this process is the coordinated T lymphocyte production of three of these proteins, granulocyte macrophage-CSF (GM-CS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf7c8013c34f080fd5e283d6d014f7d2
https://doi.org/10.4049/jimmunol.152.4.1812

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Megakaryocytes their precursors and their progeny

Autor: K, Kaushansky

Publikováno v: Trends in cardiovascular medicine. 6(8)

Although first defined nearly 40 years ago, the existence of thrombopoietin, the primary regulator of megakaryocyte and platelet production, was in doubt until only very recently. Since the initial reports of its cloning in 1994, much has been learne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d70fdc40a1c2dc25979ac0e2cd035fd
https://pubmed.ncbi.nlm.nih.gov/21232306

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Transcriptional regulation of interleukin 3 (IL3) in primary human T lymphocytes. Role of AP-1- and octamer-binding proteins in control of IL3 gene expression

Autor: Lee Levitt, Joo-Hung Park, K. Kaushansky

Publikováno v: Journal of Biological Chemistry. 268:6299-6308

We have investigated the molecular and biochemical basis for activation of interleukin 3 (IL3) gene expression in primary human T lymphocytes following CD3 and CD2 receptor stimulation or activation by phytohemagglutinin plus phorbol 12-myristate 13-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::873e37b2344c064167015e17aa5c0b57
https://doi.org/10.1016/s0021-9258(18)53253-1

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Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro

Autor: R Hromas, N Lin, K Kaushansky, L Bavisotto

Publikováno v: The Journal of Experimental Medicine

Zinc finger proteins are transcriptional regulators of other genes, often controlling developmental cascades of gene expression. A recently cloned zinc finger gene, MZF-1, was found to be preferentially expressed in myeloid cells. Using complementary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484961d931dd7694508d2f6ab240bf36
https://doi.org/10.1084/jem.174.5.1097

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In vivo production of interleukin-5, granulocyte-macrophage colony- stimulating factor, macrophages colony-stimulating factor, and interleukin-6 during intravenous administration of high-dose interleukin-2 in cancer patients [see comments]

Autor: K Kaushansky, JH Falkenburg, R Willemze, G Wagemaker, N Duinkerken, S Osanto, JE Landegent, J Van Damme, Schaafsma, P Ralph

Publikováno v: Blood. 78:1981-1987

Recombinant human interleukin-2 (IL-2), administered to cancer patients by continuous intravenous (IV) infusion (3 x 10(6) U/m2/d), was found to induce the in vivo production of colony-stimulating factors (CSF). Plasma obtained from patients during I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b125d88638d2f2e6072de250554d5a0
https://doi.org/10.1182/blood.v78.8.1981.1981

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A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells

Autor: F S Hagen, S J Collins, Robert Hromas, P O'Hara, D Hickstein, W Raskind, L L Deaven, K Kaushansky

Publikováno v: Journal of Biological Chemistry. 266:14183-14187

Zinc finger genes encode metal-binding proteins that can act as transcriptional regulators of other genes. In an effort to identify activators of the genetic cascade in hemopoietic differentiation, we used degenerate synthetic oligonucleotides to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a1ddd15d9f4f38b7bfc53ae9fb11488
https://doi.org/10.1016/s0021-9258(18)98664-3

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Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha

Autor: J M Alvaro-Gracia, N J Zvaifler, C B Brown, K Kaushansky, G S Firestein

Publikováno v: The Journal of Immunology. 146:3365-3371

Granulocyte-macrophage CSF (GM-CSF) is a potent stimulator of macrophages and neutrophils and is produced by rheumatoid arthritis (RA) synovium. We now report studies that identify some of the synovial cells and cytokines responsible for local GM-CSF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcb9eda40f06398aa226ce4419a13b24
https://doi.org/10.4049/jimmunol.146.10.3365

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